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Peer-reviewedCC BY 4.0Frontiers in Immunology

The contribution of the CTRP family and its receptors to fibrotic diseases

  • Shiena Tanaka1
  • Hina Nozawai1
  • Hsi-Hua Chi1
  • Hiroki Ueno1
  • Yayoi Tsuruzoe1
  • Nanami Sakaguchi1
  • Rio Tsukamoto1
  • Shoko Fujiyoshi1
  • Sung-Il Lee1
  • Masanori A. Murayama1
  1. 1Department of Animal Models for Human Diseases, Institute of Biomedical Science, Kansai Medical University
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Abstract

Adiponectin and other 15 members of the complement C1q/tumor necrosis factor (TNF)-related protein (CTRP) are proteins secreted primarily from adipose tissue; furthermore, recent studies have revealed their expression in various other tissues. Beyond their roles as adipokines, CTRPs critically regulate fibrogenic responses in renal and cardiovascular tissues. Adiponectin exerts its biological functions via AdipoR1, AdipoR2, and Cadherin-13 (known as T-cadherin), while several CTRPs share AdipoR1 and AdipoR2 as functional receptors. This review summarizes the current understanding of the protective effects of the CTRP family in fibrotic diseases. Future studies utilizing gain-of-function and loss-of-function animal models with single or double genetic mutations will elucidate the detailed molecular mechanisms, including the identification of functional receptors, involved in CTRP-mediated regulation of fibrotic diseases.

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Cite

BibTeXRIS
BibTeX
@article{tanaka2026contribution,
  title = {{The contribution of the CTRP family and its receptors to fibrotic diseases}},
  author = {Shiena Tanaka and Hina Nozawai and Hsi-Hua Chi and Hiroki Ueno and Yayoi Tsuruzoe and Nanami Sakaguchi and Rio Tsukamoto and Shoko Fujiyoshi and Sung-Il Lee and Masanori A. Murayama},
  journal = {Frontiers in Immunology},
  year = {2026},
  month = oct,
  doi = {10.3389/fimmu.2026.1869146},
  url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1869146/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - The contribution of the CTRP family and its receptors to fibrotic diseases
AU  - Shiena Tanaka
AU  - Hina Nozawai
AU  - Hsi-Hua Chi
AU  - Hiroki Ueno
AU  - Yayoi Tsuruzoe
AU  - Nanami Sakaguchi
AU  - Rio Tsukamoto
AU  - Shoko Fujiyoshi
AU  - Sung-Il Lee
AU  - Masanori A. Murayama
PY  - 2026
DA  - 2026/10/19
JO  - Frontiers in Immunology
DO  - 10.3389/fimmu.2026.1869146
UR  - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1869146/full
AB  - Adiponectin and other 15 members of the complement C1q/tumor necrosis factor (TNF)-related protein (CTRP) are proteins secreted primarily from adipose tissue; furthermore, recent studies have revealed their expression in various other tissues. Beyond their roles as adipokines, CTRPs critically regulate fibrogenic responses in renal and cardiovascular tissues. Adiponectin exerts its biological functions via AdipoR1, AdipoR2, and Cadherin-13 (known as T-cadherin), while several CTRPs share AdipoR1 and AdipoR2 as functional receptors. This review summarizes the current understanding of the protective effects of the CTRP family in fibrotic diseases. Future studies utilizing gain-of-function and loss-of-function animal models with single or double genetic mutations will elucidate the detailed molecular mechanisms, including the identification of functional receptors, involved in CTRP-mediated regulation of fibrotic diseases.
SN  - 1664-3224
ER  -