Skip to content
DraconiticResearch
Search Sources API
194,161 studies31 sourcesUpdated 50 min ago
Peer-reviewedCC BYJournal of the Royal Society, Interface

Coffee-ring effect enables correlative super-resolution imaging of label-free chromosomes.

  • Yanxin Dou1
  • Valerie S T Goh2
  • Thomas Osipowicz3
  • Christelle E L Chua2
  1. 1Institute of Modern Physics, Chinese Academy of Sciences , Lanzhou, People's Republic of China.
  2. 2Singapore Nuclear Research and Safety Institute, National University of Singapore , Singapore.
  3. 3Centre for Ion Beam Applications, Department of Physics, National University of Singapore , Singapore.
Read full textPDFDOICite

Abstract

High-resolution chromosome imaging plays a key role in understanding chromosome structure. However, traditional methods for super-resolution (<200 nm) chromosome imaging are often complex and time-consuming, requiring purification, staining or sectioning of chromosomes. Here, we propose a novel and simple method to achieve correlative super-resolution imaging for label-free chromosomes through the utilization of the coffee-ring effect. An application of this method is shown to identify dicentric chromosomes and acentric fragments.

Related

  1. Environment-Tolerant Blinking Fluorophores Enable Dual-Color Super-Resolution Correlative Light and Electron Microscopy
    Xingfu Zhu, Ze-Hua Wu, Xin Zhou +15
    ChemRxivPreprintCC BYFull textBiophysicsChemRxiv
  2. Small Supernumerary Marker Chromosomes in Humans: From Classical Cytogenetics to High-Resolution Cytogenomics
    Nikolay B. Rubtsov, Tatyana V. Karamysheva, Anna A. Kashevarova +1
    International Journal of Molecular SciencesPeer-reviewedCC BY 4.0General biochemistryCrossref
  3. Rapid Fabrication of Sub‐100 µm Microstructures In Situ via Femtosecond Laser for Correlative Imaging of Rare Cells
    Aristide Djoulde, Yaping Chen, Vahid R. Adineh +4
    Small (Weinheim an Der Bergstrasse, Germany)Peer-reviewedCC BY-NC-ND 4.0Full textStructural biologyPMC
  4. Super-Resolution Processing Enables In Situ Subtomogram Averaging Beyond the Nyquist Limit
    E. Pyle, S. Bekbayev, V. Dmello +1
    bioRxivPreprintCC BYFull textMolecular biology & gene regulationbioRxiv
  5. Quantum-sensing-based super-resolution live cell microenvironment imaging
    Yuxian Lu, Yibo Yang, Ke Xu +8
    Nature CommunicationsPeer-reviewedCC BY-NC-ND 4.0Full textBiophysicsCrossref

Cite

BibTeXRIS
BibTeX
@article{dou2026coffeering,
  title = {{Coffee-ring effect enables correlative super-resolution imaging of label-free chromosomes.}},
  author = {Yanxin Dou and Valerie S T Goh and Thomas Osipowicz and Christelle E L Chua},
  journal = {Journal of the Royal Society, Interface},
  year = {2026},
  month = oct,
  doi = {10.1098/rsif.2026.0072},
  url = {https://europepmc.org/article/MED/42869462},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Coffee-ring effect enables correlative super-resolution imaging of label-free chromosomes.
AU  - Yanxin Dou
AU  - Valerie S T Goh
AU  - Thomas Osipowicz
AU  - Christelle E L Chua
PY  - 2026
DA  - 2026/10/01
JO  - Journal of the Royal Society, Interface
DO  - 10.1098/rsif.2026.0072
UR  - https://europepmc.org/article/MED/42869462
AB  - High-resolution chromosome imaging plays a key role in understanding chromosome structure. However, traditional methods for super-resolution (<200 nm) chromosome imaging are often complex and time-consuming, requiring purification, staining or sectioning of chromosomes. Here, we propose a novel and simple method to achieve correlative super-resolution imaging for label-free chromosomes through the utilization of the coffee-ring effect. An application of this method is shown to identify dicentric chromosomes and acentric fragments.
SN  - 1742-5689
SN  - 1742-5662
ER  -