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Peer-reviewedCC BY-NC-NDTranslational psychiatry

Network localization of brain structural and functional alterations induced by electroconvulsive therapy for depression.

  • Shanwen Yao1,2,3
  • Dao-Min Zhu4,5,6
  • Huimin Zhu1,2,3
  • Shuang Xu1,2,3
  • Fan Mo1,2,3
  • Jiajia Zhu7,8,9
  • Yongqiang Yu10,11,12
12 affiliations
  1. 1Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
  2. 2Research Center of Clinical Medical Imaging, Anhui Province, Hefei, 230032, China.
  3. 3Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, 230032, China.
  4. 4Department of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, 230022, China.
  5. 5Hefei Fourth People's Hospital, Hefei, 230022, China.
  6. 6Anhui Mental Health Center, Hefei, 230022, China.
  7. 7Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. [email protected].
  8. 8Research Center of Clinical Medical Imaging, Anhui Province, Hefei, 230032, China. [email protected].
  9. 9Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, 230032, China. [email protected].
  10. 10Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. [email protected].
  11. 11Research Center of Clinical Medical Imaging, Anhui Province, Hefei, 230032, China. [email protected].
  12. 12Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization, Hefei, 230032, China. [email protected].
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Abstract

Extensive longitudinal neuroimaging research has investigated brain structural and functional changes following electroconvulsive therapy (ECT) for depression. However, neither the regional nor the global brain effects reported in previous research can satisfactorily explain all aspects of the antidepressant efficacy of ECT, pointing to a potentially more refined network-specific mechanism. We initially identified the locations of brain structural and functional alterations induced by ECT for depression from 34 published studies, including 15 voxel-based morphometry studies with 596 depressed individuals and 19 resting-state functional magnetic resonance imaging studies with 436 depressed individuals. By combining these affected brain locations with large-scale brain functional connectome datasets (1113 healthy and 255 clinical individuals), we then adopted a novel functional connectivity network mapping approach to construct ECT-modulated structural and functional alteration networks. Our data showed different and specific ECT-modulated structural and functional alteration networks, with the former predominantly involving the subcortical (hippocampus and amygdala), ventral attention (insula and operculum and temporoparietal junction) and somatomotor (precentral and postcentral gyrus) networks, while the latter mainly implicating the default network (medial prefrontal cortex and posterior cingulate cortex). These findings may not only reconcile prior discrepancy between the ECT-induced regional and global brain changes from a network perspective, but also suggest a dissociation between the brain structural and functional effects of ECT.

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Cite

BibTeXRIS
BibTeX
@article{yao2026network,
  title = {{Network localization of brain structural and functional alterations induced by electroconvulsive therapy for depression.}},
  author = {Shanwen Yao and Dao-Min Zhu and Huimin Zhu and Shuang Xu and Fan Mo and Jiajia Zhu and Yongqiang Yu},
  journal = {Translational psychiatry},
  year = {2026},
  month = jul,
  doi = {10.1038/s41398-026-04308-8},
  url = {https://europepmc.org/article/MED/42901907},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Network localization of brain structural and functional alterations induced by electroconvulsive therapy for depression.
AU  - Shanwen Yao
AU  - Dao-Min Zhu
AU  - Huimin Zhu
AU  - Shuang Xu
AU  - Fan Mo
AU  - Jiajia Zhu
AU  - Yongqiang Yu
PY  - 2026
DA  - 2026/07/01
JO  - Translational psychiatry
DO  - 10.1038/s41398-026-04308-8
UR  - https://europepmc.org/article/MED/42901907
AB  - Extensive longitudinal neuroimaging research has investigated brain structural and functional changes following electroconvulsive therapy (ECT) for depression. However, neither the regional nor the global brain effects reported in previous research can satisfactorily explain all aspects of the antidepressant efficacy of ECT, pointing to a potentially more refined network-specific mechanism. We initially identified the locations of brain structural and functional alterations induced by ECT for depression from 34 published studies, including 15 voxel-based morphometry studies with 596 depressed individuals and 19 resting-state functional magnetic resonance imaging studies with 436 depressed individuals. By combining these affected brain locations with large-scale brain functional connectome datasets (1113 healthy and 255 clinical individuals), we then adopted a novel functional connectivity network mapping approach to construct ECT-modulated structural and functional alteration networks. Our data showed different and specific ECT-modulated structural and functional alteration networks, with the former predominantly involving the subcortical (hippocampus and amygdala), ventral attention (insula and operculum and temporoparietal junction) and somatomotor (precentral and postcentral gyrus) networks, while the latter mainly implicating the default network (medial prefrontal cortex and posterior cingulate cortex). These findings may not only reconcile prior discrepancy between the ECT-induced regional and global brain changes from a network perspective, but also suggest a dissociation between the brain structural and functional effects of ECT.
SN  - 2158-3188
ER  -