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Peer-reviewedCC BY 4.0International Journal of Retina and Vitreous

Association between peripapillary OCTA parameters and non-proliferative diabetic retinopathy: a cross-sectional study

  • Ru Zhou1
  • Jun Zhang1
  • Zichen Wang1
  • Yiyi Chen1
  • Wei Dong1
  • Yanhan Fan1
  • Bin Yang1
  1. 1Department of Ophthalmology, People’s Hospital of Yangzhong City, No. 235 Yangzi Middle Road, Yangzhong City, Zhenjiang, Jiangsu 212200 China
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Abstract

Purpose: This study aimed to compare peripapillary OCTA parameters between eyes with no diabetic retinopathy (NDR) and those with non-proliferative diabetic retinopathy (NPDR), and to investigate their independent associations with NPDR status.

Methods: This cross-sectional study enrolled 128 healthy controls and 116 patients with type 2 diabetes mellitus. Diabetic eyes were categorized into the NDR group (n = 41 eyes) and mild, moderate, and severe NPDR groups (n = 32, 23, and 20 eyes, respectively). All subjects underwent peripapillary OCTA scanning. We quantitatively analyzed nerve fiber layer vascular plexus vessel density (NFLVPVD) and superficial vascular plexus vessel density (SVPVD), as well as peripapillary retinal nerve fiber layer (pRNFL) thickness. Baseline characteristics and OCTA quantitative parameters were compared across the control, NDR, and three NPDR subgroups. Multivariable-adjusted logistic regression was then performed to examine the association between peripapillary OCTA parameters and NPDR.

Results: Compared with the NDR group, NFLVPVD, SVPVD, inferior 3-mm pRNFL thickness, and superior 6-mm pRNFL thickness were significantly lower in the pooled NPDR group (all P < 0.05). In multivariable-adjusted binary logistic regression, higher NFLVPVD was independently associated with lower odds of NPDR (OR = 0.884, 95% CI: 0.800–0.977, P = 0.016).

Conclusions: Peripapillary NFLVPVD is independently associated with lower odds of NPDR.

Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s40942-026-00914-2.

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Cite

BibTeXRIS
BibTeX
@article{zhou2026association,
  title = {{Association between peripapillary OCTA parameters and non-proliferative diabetic retinopathy: a cross-sectional study}},
  author = {Ru Zhou and Jun Zhang and Zichen Wang and Yiyi Chen and Wei Dong and Yanhan Fan and Bin Yang},
  journal = {International Journal of Retina and Vitreous},
  year = {2026},
  month = jul,
  doi = {10.1186/s40942-026-00914-2},
  url = {https://doi.org/10.1186/s40942-026-00914-2},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Association between peripapillary OCTA parameters and non-proliferative diabetic retinopathy: a cross-sectional study
AU  - Ru Zhou
AU  - Jun Zhang
AU  - Zichen Wang
AU  - Yiyi Chen
AU  - Wei Dong
AU  - Yanhan Fan
AU  - Bin Yang
PY  - 2026
DA  - 2026/07/31
JO  - International Journal of Retina and Vitreous
DO  - 10.1186/s40942-026-00914-2
UR  - https://doi.org/10.1186/s40942-026-00914-2
AB  - Purpose: This study aimed to compare peripapillary OCTA parameters between eyes with no diabetic retinopathy (NDR) and those with non-proliferative diabetic retinopathy (NPDR), and to investigate their independent associations with NPDR status.  Methods: This cross-sectional study enrolled 128 healthy controls and 116 patients with type 2 diabetes mellitus. Diabetic eyes were categorized into the NDR group (n = 41 eyes) and mild, moderate, and severe NPDR groups (n = 32, 23, and 20 eyes, respectively). All subjects underwent peripapillary OCTA scanning. We quantitatively analyzed nerve fiber layer vascular plexus vessel density (NFLVPVD) and superficial vascular plexus vessel density (SVPVD), as well as peripapillary retinal nerve fiber layer (pRNFL) thickness. Baseline characteristics and OCTA quantitative parameters were compared across the control, NDR, and three NPDR subgroups. Multivariable-adjusted logistic regression was then performed to examine the association between peripapillary OCTA parameters and NPDR.  Results: Compared with the NDR group, NFLVPVD, SVPVD, inferior 3-mm pRNFL thickness, and superior 6-mm pRNFL thickness were significantly lower in the pooled NPDR group (all P < 0.05). In multivariable-adjusted binary logistic regression, higher NFLVPVD was independently associated with lower odds of NPDR (OR = 0.884, 95% CI: 0.800–0.977, P = 0.016).  Conclusions: Peripapillary NFLVPVD is independently associated with lower odds of NPDR.  Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s40942-026-00914-2.
SN  - 2056-9920
ER  -