[Prognostic Models and Clinical Translation Prospects of Lung Cancer Based on Novel Cell Death Modes].
- 1Shandong Medical and Pharmaceutical University, Yantai 264003, China.
Abstract
As one of the malignant tumors with high incidence and mortality worldwide, lung cancer features high heterogeneity and therapeutic resistance, which severely impair the prognosis of patients with lung cancer. In recent years, novel cell death modes such as ferroptosis, cuproptosis, disulfidptosis and necrosis by sodium overload have become research hotspots in oncology. Focusing on these four forms of cell death, this review systematically clarifies their roles in lung cancer initiation and progression, regulation of the tumor microenvironment, and therapeutic resistance; summarizes related prognostic biomarkers and representative prognostic models; and discusses the crosstalk among multiple cell death pathways and advances in clinical translation. This review aims to provide a reference for improving prognostic assessment in lung cancer, elucidating mechanisms of therapeutic resistance, and developing novel antitumor strategies.
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BibTeX
@article{sun2026prognostic,
title = {{[Prognostic Models and Clinical Translation Prospects of Lung Cancer Based on Novel Cell Death Modes].}},
author = {Linjie Sun and Yunkai You and Ying Zhang and Xintong Jiang and Shuyang Xie and Pingyu Wang},
journal = {Zhongguo fei ai za zhi = Chinese journal of lung cancer},
year = {2026},
month = aug,
doi = {10.3779/j.issn.1009-3419.2026.101.19},
url = {https://europepmc.org/article/MED/42896973},
note = {CC BY},
}
RIS
TY - JOUR
TI - [Prognostic Models and Clinical Translation Prospects of Lung Cancer Based on Novel Cell Death Modes].
AU - Linjie Sun
AU - Yunkai You
AU - Ying Zhang
AU - Xintong Jiang
AU - Shuyang Xie
AU - Pingyu Wang
PY - 2026
DA - 2026/08/01
JO - Zhongguo fei ai za zhi = Chinese journal of lung cancer
DO - 10.3779/j.issn.1009-3419.2026.101.19
UR - https://europepmc.org/article/MED/42896973
AB - As one of the malignant tumors with high incidence and mortality worldwide, lung cancer features high heterogeneity and therapeutic resistance, which severely impair the prognosis of patients with lung cancer. In recent years, novel cell death modes such as ferroptosis, cuproptosis, disulfidptosis and necrosis by sodium overload have become research hotspots in oncology. Focusing on these four forms of cell death, this review systematically clarifies their roles in lung cancer initiation and progression, regulation of the tumor microenvironment, and therapeutic resistance; summarizes related prognostic biomarkers and representative prognostic models; and discusses the crosstalk among multiple cell death pathways and advances in clinical translation. This review aims to provide a reference for improving prognostic assessment in lung cancer, elucidating mechanisms of therapeutic resistance, and developing novel antitumor strategies.
SN - 1009-3419
SN - 1999-6187
ER -