Mapping the genetic and genomic landscape of assisted reproductive technology outcomes: a bibliometric analysis (2014–2025)
- 1Symbiosis Institute of Health Sciences, Symbiosis International (Deemed University), Pune, India
Abstract
Infertility is a major global health concern, and assisted reproductive technology (ART) is widely used to support conception. Genetic and genomic applications have increasingly been incorporated into ART to improve embryo selection and reproductive risk stratification; however, their impact on clinical outcomes such as live birth rates remains debated. This study aimed to evaluate global research trends and thematic development related to genetic and genomic applications in ART outcomes from 2014 to 2025. A bibliometric analysis was conducted using publications retrieved from Scopus, Web of Science, and PubMed. Following metadata harmonisation and duplicate removal using Bibliometrix in RStudio, 4876 unique publications were retained from 8533 records. Biblioshiny and VOSviewer were used to analyse publication trends, collaboration networks, thematic evolution, keyword co-occurrence, and citation patterns. Normalised citation indicators, including citations per year, were applied to minimise temporal bias. Publication output increased markedly after 2018, reflecting growing interest in genomic applications within ART. Research productivity was concentrated in high-income countries, particularly the USA, China, and Europe. Key research themes included embryo aneuploidy screening, preimplantation genetic testing, sequencing technologies, implantation outcomes, miscarriage reduction, and live birth prediction. Emerging themes included non-invasive embryo assessment, embryo mosaicism, and multi-omics integration. Genetic and genomic technologies have substantially influenced ART research, particularly in embryo assessment and reproductive outcome prediction. Future studies should prioritise clinical validation, standardised reporting, and broader international collaboration to determine the reproductive benefits of genomic innovations in ART.
Related
- Trace Element Concentrations in Follicular Fluid and Serum and Their Association with Assisted Reproductive Technology Outcomes: Preliminary Evidence
- Association of pre-treatment sleep characteristics with reproductive outcomes among women undergoing assisted reproductive technology: a retrospective cohort study
- Impact of surgical versus spontaneous fetal reduction on maternal and neonatal outcomes after assisted reproductive technology: a single-center cohort study of 1, 451 singleton live births
- Oocyte Maturation and Fertilization-Related Outcomes Following a Pro-Fertility Diet Combined with Omega-3 Supplementation in Women Undergoing Assisted Reproductive Technology: A Secondary Analysis of a Randomized Controlled Trial.
- Editorial: Advancing embryo transfer in assisted reproductive technology
BibTeX
@article{soni2026mapping,
title = {{Mapping the genetic and genomic landscape of assisted reproductive technology outcomes: a bibliometric analysis (2014–2025)}},
author = {Meghavi Soni and Shalaka Ramgir-Naidu},
journal = {Journal of Assisted Reproduction and Genetics},
year = {2026},
month = jun,
doi = {10.1007/s10815-026-03937-8},
url = {https://doi.org/10.1007/s10815-026-03937-8},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Mapping the genetic and genomic landscape of assisted reproductive technology outcomes: a bibliometric analysis (2014–2025)
AU - Meghavi Soni
AU - Shalaka Ramgir-Naidu
PY - 2026
DA - 2026/06/29
JO - Journal of Assisted Reproduction and Genetics
DO - 10.1007/s10815-026-03937-8
UR - https://doi.org/10.1007/s10815-026-03937-8
AB - Infertility is a major global health concern, and assisted reproductive technology (ART) is widely used to support conception. Genetic and genomic applications have increasingly been incorporated into ART to improve embryo selection and reproductive risk stratification; however, their impact on clinical outcomes such as live birth rates remains debated. This study aimed to evaluate global research trends and thematic development related to genetic and genomic applications in ART outcomes from 2014 to 2025. A bibliometric analysis was conducted using publications retrieved from Scopus, Web of Science, and PubMed. Following metadata harmonisation and duplicate removal using Bibliometrix in RStudio, 4876 unique publications were retained from 8533 records. Biblioshiny and VOSviewer were used to analyse publication trends, collaboration networks, thematic evolution, keyword co-occurrence, and citation patterns. Normalised citation indicators, including citations per year, were applied to minimise temporal bias. Publication output increased markedly after 2018, reflecting growing interest in genomic applications within ART. Research productivity was concentrated in high-income countries, particularly the USA, China, and Europe. Key research themes included embryo aneuploidy screening, preimplantation genetic testing, sequencing technologies, implantation outcomes, miscarriage reduction, and live birth prediction. Emerging themes included non-invasive embryo assessment, embryo mosaicism, and multi-omics integration. Genetic and genomic technologies have substantially influenced ART research, particularly in embryo assessment and reproductive outcome prediction. Future studies should prioritise clinical validation, standardised reporting, and broader international collaboration to determine the reproductive benefits of genomic innovations in ART.
SN - 1058-0468
SN - 1573-7330
ER -