Peer-reviewedCC BY-NC-NDInternal Medicine
Esophageal cancer-associated thoracic central venous obstruction type 2 which occurred during chemoradiotherapy
Abstract
Thoracic central venous obstruction (TCVO) can cause facial and upper extremity edema and it is often associated with malignancies. We herein report a rare case of cervical esophageal squamous cell carcinoma complicated by TCVO type 2 during chemoradiotherapy. Approximately 1 week after starting 5-fluorouracil plus cisplatin with radiotherapy, the patient developed acute painful swelling of the left arm. Contrast-enhanced computed tomography revealed thrombosis of the left internal jugular vein with extrinsic compression of the ipsilateral subclavian vein by a cervical tumor. Symptoms improved after anticoagulation therapy while chemoradiotherapy was continued, although the improvement was likely multifactorial.
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BibTeX
@article{tokunaga2026esophageal,
title = {{Esophageal cancer-associated thoracic central venous obstruction type 2 which occurred during chemoradiotherapy}},
author = {Yoshiki Tokunaga and Kohei Hayashi and Rie Uehara and Amane Jubashi and Tomonori Araki and Takuya Honda and Hisamitsu Miyaaki},
journal = {Internal Medicine},
year = {2026},
month = aug,
doi = {10.2169/internalmedicine.8011-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8011-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Esophageal cancer-associated thoracic central venous obstruction type 2 which occurred during chemoradiotherapy
AU - Yoshiki Tokunaga
AU - Kohei Hayashi
AU - Rie Uehara
AU - Amane Jubashi
AU - Tomonori Araki
AU - Takuya Honda
AU - Hisamitsu Miyaaki
PY - 2026
DA - 2026/08/25
JO - Internal Medicine
DO - 10.2169/internalmedicine.8011-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8011-26/_article
AB - Thoracic central venous obstruction (TCVO) can cause facial and upper extremity edema and it is often associated with malignancies. We herein report a rare case of cervical esophageal squamous cell carcinoma complicated by TCVO type 2 during chemoradiotherapy. Approximately 1 week after starting 5-fluorouracil plus cisplatin with radiotherapy, the patient developed acute painful swelling of the left arm. Contrast-enhanced computed tomography revealed thrombosis of the left internal jugular vein with extrinsic compression of the ipsilateral subclavian vein by a cervical tumor. Symptoms improved after anticoagulation therapy while chemoradiotherapy was continued, although the improvement was likely multifactorial.
SN - 1349-7235
SN - 0918-2918
ER -