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Peer-reviewedCC BYNature Communications

The biology of jumbo phages

  • Sam P. B. van Beljouw1
  • Li Yuping2
  1. 1Biozentrum, University of Basel, Basel, Switzerland
  2. 2Biozentrum, University of Basel, Basel, Switzerland. [email protected]
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Abstract

Jumbo bacteriophages are bacterial viruses with double-stranded DNA genomes exceeding 200 kb. These viral giants feature exceptionally large virions, expansive genetic repertoires, and in some cases, remarkable eukaryotic-like traits. Jumbo phages challenge long-standing notions of phage simplicity, redefining the boundaries of what a phage can be. In this Review, we examine the biology of jumbo bacteriophages, highlighting their diversity, evolutionary origins, distinctive morphologies and lifecycles, complex interactions with bacterial hosts, and their potential for biotechnology and therapy, with a focus on, but not limited to, the Chimalliviridae phages.

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Cite

BibTeXRIS
BibTeX
@article{beljouw2026biology,
  title = {{The biology of jumbo phages}},
  author = {Sam P. B. van Beljouw and Li Yuping},
  journal = {Nature Communications},
  year = {2026},
  month = jun,
  doi = {10.1038/s41467-026-74333-0},
  url = {https://doi.org/10.1038/s41467-026-74333-0},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - The biology of jumbo phages
AU  - Sam P. B. van Beljouw
AU  - Li Yuping
PY  - 2026
DA  - 2026/06/19
JO  - Nature Communications
DO  - 10.1038/s41467-026-74333-0
UR  - https://doi.org/10.1038/s41467-026-74333-0
AB  - Jumbo bacteriophages are bacterial viruses with double-stranded DNA genomes exceeding 200 kb. These viral giants feature exceptionally large virions, expansive genetic repertoires, and in some cases, remarkable eukaryotic-like traits. Jumbo phages challenge long-standing notions of phage simplicity, redefining the boundaries of what a phage can be. In this Review, we examine the biology of jumbo bacteriophages, highlighting their diversity, evolutionary origins, distinctive morphologies and lifecycles, complex interactions with bacterial hosts, and their potential for biotechnology and therapy, with a focus on, but not limited to, the Chimalliviridae phages.
SN  - 2041-1723
ER  -