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Peer-reviewedCC BY-NCInternational journal of nanomedicine

Stem Cell-Derived Extracellular Vesicles in Bladder Cancer: Diagnostic Potential and Therapeutic Challenges.

  • Wenbao Lu1
  • Peng Fu2
  • Chuanxiao Li1
  • Kecheng Lou3
  • Shangzhi Feng1
  • Yuming Wang4
4 affiliations
  1. 1Department of Urology, Jiujiang University Clinic College/Hospital, Jiujiang, Jiangxi, People's Republic of China.
  2. 2Department of Breast and Thyroid Surgery, Jiujiang University Clinic College/Hospital, Jiujiang, Jiangxi, People's Republic of China.
  3. 3Department of Urology, Lanxi People's Hospital, Jinhua, Zhejiang, People's Republic of China.
  4. 4Department of Anesthesiology, Jiujiang University Clinic College/Hospital, Jiujiang, Jiangxi, People's Republic of China.
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Abstract

With population aging, the high prevalence and recurrence rate of bladder cancer increasingly threaten the health of older adults. Although surgery is effective for most early-stage bladder cancer, frequent recurrence and the risk of metastasis compromise patients' quality of life, while subsequent radical surgery can cause a substantial further decline. Advances in nanobiomedicine have highlighted nanoscale vesicles as potential tools for the early diagnosis and treatment of bladder cancer, particularly as stem cell-based and stem cell-derived vesicle-based nanomedicine approaches mature. Studies suggest that extracellular vesicles derived from mesenchymal stem cells and bladder cancer stem cells, enriched in specific bioactive molecules and characterized by strong targeting capabilities and low immunogenicity, may support early diagnosis and cell-free targeted therapy for bladder cancer, potentially reducing its high recurrence rate and risk of metastasis. This review therefore summarizes preclinical studies of extracellular vesicles derived from malignant and nonmalignant stem cells in bladder cancer and discusses their diagnostic and therapeutic potential to expand nanomedicine approaches to bladder cancer diagnosis and treatment.

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Cite

BibTeXRIS
BibTeX
@article{lu2026stem,
  title = {{Stem Cell-Derived Extracellular Vesicles in Bladder Cancer: Diagnostic Potential and Therapeutic Challenges.}},
  author = {Wenbao Lu and Peng Fu and Chuanxiao Li and Kecheng Lou and Shangzhi Feng and Yuming Wang},
  journal = {International journal of nanomedicine},
  year = {2026},
  month = nov,
  doi = {10.2147/ijn.s631382},
  url = {https://europepmc.org/article/MED/42999830},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Stem Cell-Derived Extracellular Vesicles in Bladder Cancer: Diagnostic Potential and Therapeutic Challenges.
AU  - Wenbao Lu
AU  - Peng Fu
AU  - Chuanxiao Li
AU  - Kecheng Lou
AU  - Shangzhi Feng
AU  - Yuming Wang
PY  - 2026
DA  - 2026/11/03
JO  - International journal of nanomedicine
DO  - 10.2147/ijn.s631382
UR  - https://europepmc.org/article/MED/42999830
AB  - With population aging, the high prevalence and recurrence rate of bladder cancer increasingly threaten the health of older adults. Although surgery is effective for most early-stage bladder cancer, frequent recurrence and the risk of metastasis compromise patients' quality of life, while subsequent radical surgery can cause a substantial further decline. Advances in nanobiomedicine have highlighted nanoscale vesicles as potential tools for the early diagnosis and treatment of bladder cancer, particularly as stem cell-based and stem cell-derived vesicle-based nanomedicine approaches mature. Studies suggest that extracellular vesicles derived from mesenchymal stem cells and bladder cancer stem cells, enriched in specific bioactive molecules and characterized by strong targeting capabilities and low immunogenicity, may support early diagnosis and cell-free targeted therapy for bladder cancer, potentially reducing its high recurrence rate and risk of metastasis. This review therefore summarizes preclinical studies of extracellular vesicles derived from malignant and nonmalignant stem cells in bladder cancer and discusses their diagnostic and therapeutic potential to expand nanomedicine approaches to bladder cancer diagnosis and treatment.
SN  - 1176-9114
SN  - 1178-2013
ER  -