Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact

Abstract

Extracellular matrix components such as collagens are deposited within the tumor microenvironment at primary and metastatic sites and are recognized to be critical during tumor progression and metastasis development. This study aimed to evaluate the clinical and prognostic impact of Discoidin Domain Receptor 1 (DDR1) expression in colon cancers and its association with a particular molecular and/or morphological profile and to evaluate its potential role as a prognosis biomarker. Immunohistochemical expression of DDR1 was evaluated on 292 colonic adenocarcinomas. DDR1 was highly expressed in 240 (82.2%) adenocarcinomas. High DDR1 immunostaining score was significantly associated, on univariate analysis, with male sex, left tumor location, BRAF wild type status, KRAS mutated status, and Annexin A10 negativity. High DDR1 immunohistochemical expression was associated with shorter event free survival only. Laser capture microdissection analyses revealed that DDR1 mRNA expression was mainly attributable to adenocarcinoma compared to stromal cells. The impact of DDR1 expression on cell invasion was then evaluated by modified Boyden chamber assay using cell types with distinct mutational profiles. The invasion capacity of colon adenocarcinoma is supported by DDR1 expression. Thus, our results showed that DDR1 was highly expressed in most colon adenocarcinomas and appears as an indicator of worse event free survival.

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BibTeX RIS

BibTeX

@article{arfi2026discoidin,
  title = {{Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact}},
  author = {Kaouther Ben Arfi and Christophe Schneider and Amar Bennasroune and Nicole Bouland and Aurore Wolak-Thierry and Guillaume Collin and Cuong Cao Le and Kevin Toussaint and Cathy Hachet and Véronique Lehrter and Stéphane Dedieu and Olivier Bouché and Hamid Morjani and Camille Boulagnon-Rombi and Aline Appert-Collin},
  journal = {Cancers},
  year = {2026},
  month = sep,
  doi = {10.3390/cancers14040928},
  url = {https://hal.science/hal-05746586v1},
  note = {CC BY 4.0},
}

RIS

TY  - JOUR
TI  - Discoidin Domain Receptor 1 Expression in Colon Cancer: Roles and Prognosis Impact
AU  - Kaouther Ben Arfi
AU  - Christophe Schneider
AU  - Amar Bennasroune
AU  - Nicole Bouland
AU  - Aurore Wolak-Thierry
AU  - Guillaume Collin
AU  - Cuong Cao Le
AU  - Kevin Toussaint
AU  - Cathy Hachet
AU  - Véronique Lehrter
AU  - Stéphane Dedieu
AU  - Olivier Bouché
AU  - Hamid Morjani
AU  - Camille Boulagnon-Rombi
AU  - Aline Appert-Collin
PY  - 2026
DA  - 2026/09/11
JO  - Cancers
DO  - 10.3390/cancers14040928
UR  - https://hal.science/hal-05746586v1
AB  - Extracellular matrix components such as collagens are deposited within the tumor microenvironment at primary and metastatic sites and are recognized to be critical during tumor progression and metastasis development. This study aimed to evaluate the clinical and prognostic impact of Discoidin Domain Receptor 1 (DDR1) expression in colon cancers and its association with a particular molecular and/or morphological profile and to evaluate its potential role as a prognosis biomarker. Immunohistochemical expression of DDR1 was evaluated on 292 colonic adenocarcinomas. DDR1 was highly expressed in 240 (82.2%) adenocarcinomas. High DDR1 immunostaining score was significantly associated, on univariate analysis, with male sex, left tumor location, BRAF wild type status, KRAS mutated status, and Annexin A10 negativity. High DDR1 immunohistochemical expression was associated with shorter event free survival only. Laser capture microdissection analyses revealed that DDR1 mRNA expression was mainly attributable to adenocarcinoma compared to stromal cells. The impact of DDR1 expression on cell invasion was then evaluated by modified Boyden chamber assay using cell types with distinct mutational profiles. The invasion capacity of colon adenocarcinoma is supported by DDR1 expression. Thus, our results showed that DDR1 was highly expressed in most colon adenocarcinomas and appears as an indicator of worse event free survival.
SN  - 2072-6694
SN  - 2072-6694
ER  -

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