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Peer-reviewedCC BY-NC-ND 4.0ACS Omega

Design and Construction of a Low-Cost, Open-Source Syringe-Based Pipetting Robot Using 3D Printing and Common Hardware Parts

  • Shogo Shirahata1
  • Mikael Kuwahara1
  • Fernando Garcia-Escobar1
  • Keisuke Takahashi1,2
  • Lauren Takahashi1
  1. 1Hokkaido University , , North 10, West 8 , ,
  2. 2Hokkaido University , , ,
Open at sourcePDFDOICite

Abstract

Automation in chemical laboratories improves the reproducibility, precision, and efficiency in liquid handling. A three-dimensional (3D)-printed, stepper-actuated pipetting robot was developed and tested via silver nitrate (AgNO3) experiments. The system employs a rigid 3D-printed frame to secure syringes and tubing, stepper motors for plunger actuation, and microcontroller-based software to automate the pipetting sequences. The robot was evaluated for volume accuracy, reproducibility, and mechanical reliability using 5 mL syringes. The results indicate consistent volume delivery and stable mechanical performance over multiple cycles. Detailed mechanical, electrical, and software specifications are provided to enable replication and customization in other laboratories.

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Cite

BibTeXRIS
BibTeX
@article{shirahata2026design,
  title = {{Design and Construction of a Low-Cost, Open-Source Syringe-Based Pipetting Robot Using 3D Printing and Common Hardware Parts}},
  author = {Shogo Shirahata and Mikael Kuwahara and Fernando Garcia-Escobar and Keisuke Takahashi and Lauren Takahashi},
  journal = {ACS Omega},
  year = {2026},
  month = oct,
  doi = {10.1021/acsomega.6c05778},
  url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c05778/5457689/Design-and-Construction-of-a-Low-Cost-Open-Source},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Design and Construction of a Low-Cost, Open-Source Syringe-Based Pipetting Robot Using 3D Printing and Common Hardware Parts
AU  - Shogo Shirahata
AU  - Mikael Kuwahara
AU  - Fernando Garcia-Escobar
AU  - Keisuke Takahashi
AU  - Lauren Takahashi
PY  - 2026
DA  - 2026/10/24
JO  - ACS Omega
DO  - 10.1021/acsomega.6c05778
UR  - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c05778/5457689/Design-and-Construction-of-a-Low-Cost-Open-Source
AB  - Automation in chemical laboratories improves the reproducibility, precision, and efficiency in liquid handling. A three-dimensional (3D)-printed, stepper-actuated pipetting robot was developed and tested via silver nitrate (AgNO3) experiments. The system employs a rigid 3D-printed frame to secure syringes and tubing, stepper motors for plunger actuation, and microcontroller-based software to automate the pipetting sequences. The robot was evaluated for volume accuracy, reproducibility, and mechanical reliability using 5 mL syringes. The results indicate consistent volume delivery and stable mechanical performance over multiple cycles. Detailed mechanical, electrical, and software specifications are provided to enable replication and customization in other laboratories.
SN  - 2470-1343
ER  -