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Peer-reviewedCC BYMedicina (Kaunas, Lithuania)

Peri-Interventional Prophylactic Plasma Transfusion.

  • Daniela Filipescu1,2
  • Cornelia-Elena Predoi1,2
  • Cosmin Balan1,2
  • Radu Filipescu1,2
  • Dragos Guz1,2
  • Cornelia Margineanu2
  • Cornel Robu1,2
  • Serban-Ion Bubenek-Turconi1,2
  • Mihai Gabriel Ștefan1,2
  1. 1Emergency Institute of Cardiovascular Disease "Prof. Dr. CC Iliescu", 022322 Bucharest, Romania.
  2. 2Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania.
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Abstract

Human plasma remains one of the most frequently transfused blood products despite increasing data that many transfusions are unnecessary and unsupported by clinical evidence. This review summarises current evidence regarding the haemostatic properties of therapeutic plasma, their effects on conventional coagulation tests, and contemporary use in non-bleeding patients undergoing surgery or invasive procedures, as well as for anticoagulant reversal. Conventional coagulation tests, particularly the international normalised ratio (INR), correlate poorly with bleeding risk and are only minimally corrected by commonly administered plasma doses. Current evidence demonstrates that prophylactic plasma transfusion does not reduce peri-procedural bleeding in most patients while exposing them to transfusion-related complications which can lead to worse outcomes. Recent international guidelines consistently discourage routine plasma transfusion solely to correct mildly abnormal coagulation tests, and recommend four-factor prothrombin complex concentrate rather than plasma for urgent vitamin K antagonist reversal.

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Cite

BibTeXRIS
BibTeX
@article{filipescu2026periinterventional,
  title = {{Peri-Interventional Prophylactic Plasma Transfusion.}},
  author = {Daniela Filipescu and Cornelia-Elena Predoi and Cosmin Balan and Radu Filipescu and Dragos Guz and Cornelia Margineanu and Cornel Robu and Serban-Ion Bubenek-Turconi and Mihai Gabriel Ștefan},
  journal = {Medicina (Kaunas, Lithuania)},
  year = {2026},
  month = oct,
  doi = {10.3390/medicina62101901},
  url = {https://europepmc.org/article/MED/42942432},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Peri-Interventional Prophylactic Plasma Transfusion.
AU  - Daniela Filipescu
AU  - Cornelia-Elena Predoi
AU  - Cosmin Balan
AU  - Radu Filipescu
AU  - Dragos Guz
AU  - Cornelia Margineanu
AU  - Cornel Robu
AU  - Serban-Ion Bubenek-Turconi
AU  - Mihai Gabriel Ștefan
PY  - 2026
DA  - 2026/10/01
JO  - Medicina (Kaunas, Lithuania)
DO  - 10.3390/medicina62101901
UR  - https://europepmc.org/article/MED/42942432
AB  - Human plasma remains one of the most frequently transfused blood products despite increasing data that many transfusions are unnecessary and unsupported by clinical evidence. This review summarises current evidence regarding the haemostatic properties of therapeutic plasma, their effects on conventional coagulation tests, and contemporary use in non-bleeding patients undergoing surgery or invasive procedures, as well as for anticoagulant reversal. Conventional coagulation tests, particularly the international normalised ratio (INR), correlate poorly with bleeding risk and are only minimally corrected by commonly administered plasma doses. Current evidence demonstrates that prophylactic plasma transfusion does not reduce peri-procedural bleeding in most patients while exposing them to transfusion-related complications which can lead to worse outcomes. Recent international guidelines consistently discourage routine plasma transfusion solely to correct mildly abnormal coagulation tests, and recommend four-factor prothrombin complex concentrate rather than plasma for urgent vitamin K antagonist reversal.
SN  - 1010-660X
SN  - 1648-9144
ER  -