Skip to content
DraconiticResearch
Search Sources API
186,086 studies31 sourcesUpdated 4 min ago
Peer-reviewedCC BY-NC 4.0BMJ Paediatrics Open

Association between hypertensive disorders of pregnancy and neurocognitive development in children aged 36 months: a cohort study in Matlab, Bangladesh

  • Monjur Rahman1,2
  • Shaki Aktar1
  • Nelufar Yesmin1
  • Jesmin Pervin1
  • Shamima Shiraji1
  • U Tin Nu1
  • Shams El Arifeen1
  • Jena Hamadani1
  • Anisur Rahman1
  1. 1Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh
  2. 2Rural Health Research Institute, Charles Sturt University, Orange, New South Wales, Australia
Read full textPDFDOICite

Abstract

Objectives: To evaluate the association between hypertensive disorders of pregnancy (HDP) and neurodevelopmental outcomes among children aged approximately 36 months in a rural area of Bangladesh.

Methods: The study was based on HDP cases identified within a pregnancy cohort conducted between April 2015 and March 2018. Children born to HDP-exposed mothers (n=173) and a randomly selected group of HDP-unexposed mothers (n=350) were assessed for cognitive, language and motor development using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), between November 2019 and July 2021. Multiple linear regression analysis was used to examine the associations and results were reported as adjusted mean differences in composite scores (β coefficients) with 95% CIs.

Results: Overall, children born to mothers with HDP had lower mean composite scores for cognitive (β=−1.14, 95% CI −2.06 to −0.22), language (β=−1.54, 95% CI −2.56 to −0.52) and motor (β=−2.52, 95% CI −3.95 to −1.08) development compared with children of HDP-unexposed mothers. Significant associations were also observed across several developmental subdomains. When analyses were stratified by specific HDP types, the effects were more pronounced among children exposed to chronic hypertension, whereas no significant association was detected for exposure to pre-eclampsia.

Conclusion: HDP were associated with impaired neurocognitive development among children in a rural area of Bangladesh. The strength of these associations varied across developmental domains and by specific HDP types.

Related

  1. Association of Placental Morphological Abnormalities with Adverse Pregnancy Outcomes in Hypertensive Disorders of Pregnancy: A Propensity Score-Matched Cohort Study
    Hui Tao, Lei Sun, Ruilin Ma +8
    International Journal of Women's HealthPeer-reviewedCC BY-NC 4.0Full textObstetrics, gynaecology & paediatricsPMC
  2. Association between Plasma Short-Chain Fatty Acids and Hypertensive Disorders of Pregnancy: A Nested Case-Control Study
    Dandan Wang, Lei Wu, Pei Feng +5
    Maternal-fetal medicine (Wolters Kluwer Health, Inc.)Peer-reviewedCC BY-NC-NDFull textObstetrics, gynaecology & paediatricsEurope PMCDOAJ
  3. Circulating and cerebrospinal fluid soluble TREM2 levels and risk of perioperative neurocognitive disorders in surgical patients: a systematic review and meta-analysis
    Haotian Wu, Yujie Wang, Zhifeng Gao +1
    Frontiers in aging neurosciencePeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Planned early birth versus expectant management for hypertensive disorders from 34 weeks' gestation to term
    Alice Beardmore-Gray, Christa Rohwer, Cristina Fernandez Turienzo +1
    The Cochrane Database of Systematic ReviewsPeer-reviewedPublisher termsFull text1 citedObstetrics, gynaecology & paediatricsPMC
  5. Hypertension in People with Multiple Sclerosis: Epidemiology, Mechanisms, Hypertensive Disorders of Pregnancy, and Clinical Implications.
    Ahmed Arafa, Amira S A Said, Ehab Elkady +3
    Diseases (Basel, Switzerland)Peer-reviewedCC BYFull textGeneral medicineEurope PMC

Cite

BibTeXRIS
BibTeX
@article{rahman2026association,
  title = {{Association between hypertensive disorders of pregnancy and neurocognitive development in children aged 36 months: a cohort study in Matlab, Bangladesh}},
  author = {Monjur Rahman and Shaki Aktar and Nelufar Yesmin and Jesmin Pervin and Shamima Shiraji and U Tin Nu and Shams El Arifeen and Jena Hamadani and Anisur Rahman},
  journal = {BMJ Paediatrics Open},
  year = {2026},
  month = oct,
  doi = {10.1136/bmjpo-2025-004246},
  url = {https://doi.org/10.1136/bmjpo-2025-004246},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Association between hypertensive disorders of pregnancy and neurocognitive development in children aged 36 months: a cohort study in Matlab, Bangladesh
AU  - Monjur Rahman
AU  - Shaki Aktar
AU  - Nelufar Yesmin
AU  - Jesmin Pervin
AU  - Shamima Shiraji
AU  - U Tin Nu
AU  - Shams El Arifeen
AU  - Jena Hamadani
AU  - Anisur Rahman
PY  - 2026
DA  - 2026/10/31
JO  - BMJ Paediatrics Open
DO  - 10.1136/bmjpo-2025-004246
UR  - https://doi.org/10.1136/bmjpo-2025-004246
AB  - Objectives: To evaluate the association between hypertensive disorders of pregnancy (HDP) and neurodevelopmental outcomes among children aged approximately 36 months in a rural area of Bangladesh.  Methods: The study was based on HDP cases identified within a pregnancy cohort conducted between April 2015 and March 2018. Children born to HDP-exposed mothers (n=173) and a randomly selected group of HDP-unexposed mothers (n=350) were assessed for cognitive, language and motor development using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), between November 2019 and July 2021. Multiple linear regression analysis was used to examine the associations and results were reported as adjusted mean differences in composite scores (β coefficients) with 95% CIs.  Results: Overall, children born to mothers with HDP had lower mean composite scores for cognitive (β=−1.14, 95% CI −2.06 to −0.22), language (β=−1.54, 95% CI −2.56 to −0.52) and motor (β=−2.52, 95% CI −3.95 to −1.08) development compared with children of HDP-unexposed mothers. Significant associations were also observed across several developmental subdomains. When analyses were stratified by specific HDP types, the effects were more pronounced among children exposed to chronic hypertension, whereas no significant association was detected for exposure to pre-eclampsia.  Conclusion: HDP were associated with impaired neurocognitive development among children in a rural area of Bangladesh. The strength of these associations varied across developmental domains and by specific HDP types.
SN  - 2399-9772
ER  -