Non-contact optical imaging of tissue deformation enables in vivo cardiovascular monitoring
- 1Johns Hopkins University School of Medicine
Abstract
Significance: Continuous, non-invasive monitoring of cardiovascular physiology provides critical information for clinical decision-making and patient care. Emerging optical sensors enable non-contact measurement of physiological parameters such as heart rate and respiratory rate, but current methods are limited in their ability to capture spatially resolved physiological waveforms. Aim: We aimed to extend the capabilities of non-contact cardiovascular monitoring by using an imaging-based approach from which spatially resolved physiological waveforms can be extracted and cardiovascular biomarkers can be derived in vivo. Approach: We implemented a digital holographic imaging sensor to continuously measure calibrated tissue motion for in vivo assessment of cardiovascular biomarkers in six adult male Sprague-Dawley rats, with validation against electrocardiographic and invasive arterial blood pressure measurements. Results: Heart rate and pulse arrival time-derived pulse wave velocity calculated from digital holographic imaging demonstrate strong agreement with reference-derived metrics (concordance correlation coefficient [≥] 0.98). Heart rate variability shows moderate agreement with reference-derived metrics (concordance correlation coefficient [≥] 0.59).
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BibTeX
@misc{lefebvre2026noncontact,
title = {{Non-contact optical imaging of tissue deformation enables in vivo cardiovascular monitoring}},
author = {A. T. Lefebvre and N. E. Steiner and S. Wang and C. L. Rodriguez and E. Bar-Kochba and Y. Shi and S.-M. Cho and D. W. Blodgett and M. Mirski},
howpublished = {bioRxiv},
year = {2026},
month = sep,
doi = {10.64898/2026.09.04.749131},
url = {https://www.biorxiv.org/content/10.64898/2026.09.04.749131v1},
note = {CC BY-NC},
}
RIS
TY - UNPB
TI - Non-contact optical imaging of tissue deformation enables in vivo cardiovascular monitoring
AU - A. T. Lefebvre
AU - N. E. Steiner
AU - S. Wang
AU - C. L. Rodriguez
AU - E. Bar-Kochba
AU - Y. Shi
AU - S.-M. Cho
AU - D. W. Blodgett
AU - M. Mirski
PY - 2026
DA - 2026/09/04
PB - bioRxiv
DO - 10.64898/2026.09.04.749131
UR - https://www.biorxiv.org/content/10.64898/2026.09.04.749131v1
AB - Significance: Continuous, non-invasive monitoring of cardiovascular physiology provides critical information for clinical decision-making and patient care. Emerging optical sensors enable non-contact measurement of physiological parameters such as heart rate and respiratory rate, but current methods are limited in their ability to capture spatially resolved physiological waveforms. Aim: We aimed to extend the capabilities of non-contact cardiovascular monitoring by using an imaging-based approach from which spatially resolved physiological waveforms can be extracted and cardiovascular biomarkers can be derived in vivo. Approach: We implemented a digital holographic imaging sensor to continuously measure calibrated tissue motion for in vivo assessment of cardiovascular biomarkers in six adult male Sprague-Dawley rats, with validation against electrocardiographic and invasive arterial blood pressure measurements. Results: Heart rate and pulse arrival time-derived pulse wave velocity calculated from digital holographic imaging demonstrate strong agreement with reference-derived metrics (concordance correlation coefficient [≥] 0.98). Heart rate variability shows moderate agreement with reference-derived metrics (concordance correlation coefficient [≥] 0.59).
ER -