Antioxidant, cytotoxic and alpha-glucosidase inhibition activities from the Mexican berry “Anacahuita” (Cordia boissieri)
- 1Universidad Autónoma de Nuevo León, Facultad de Ciencias Biológicas, San Nicolás de los Garza, Nuevo León. México
- 2Instituto Mexicano del Seguro Social, Centro de Investigación Biomédica del Noreste, Monterrey, Nuevo León. México
Abstract
This study describes the total phenolic and flavonoid content as well as cytotoxic, alpha-glucosidase inhibition and antiradical/antioxidant potential of extracts obtained from the edible fruits of Cordia boissieri, which is widely distributed throughout northeastern Mexico. Phenolic and flavonoid content were evaluated by means of the Folin-Ciocalteu method and aluminum chloride colorimetric assay respectively. The antiradical/antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Trolox Equivalent Antioxidant Capacity (TEAC) assays. Cytotoxic activity was assessed by means of human cancer cell lines (MCF-7 and HeLa), alpha-glucosidase inhibition was determined by colorimetric assay using p-Nitrophenyl a-D-glucopyranoside (PNPG) as a substrate. Results indicate that extract of C. boissieri fruit has a good antioxidant potential to show a EC₅₀: 137.76 ± 35 ptg/mL and 65 ±2 ltM/g in the DPPH and TEAC assays respectively, inhibitor of the enzyme alpha-glu- cosidase involved in sugar uptake (ICSO: 215.20 ± 35 μg/ mL), cytotoxic activities against MCF-7 (IC50: 310 ± 42 μg/mL) and HeLa (IC₅₀0: 450.4 ±21μgg/mL) cancer cell lines as well as an important phenolic content with 230 t 23 mg/1OOg and 54±11 mg100g g of phenols and flavonoids totals respectively. These results point towards an interesting potential for the fruits of C. boissieri as chemopreventive properties and expand the possibilities.
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BibTeX
@article{viverosvaldez2026antioxidant,
title = {{Antioxidant, cytotoxic and alpha-glucosidase inhibition activities from the Mexican berry “Anacahuita” (Cordia boissieri)}},
author = {Ezequiel Viveros‐Valdez and Carlos Jaramillo-Mora and Azucena Oranday-Cárdenas and Javier Morán‐Martínez and Pilar Carranza‐Rosales},
journal = {Archivos Latinoamericanos de Nutrición},
year = {2026},
month = oct,
doi = {10.37527/2016.66.3.007},
url = {https://doi.org/10.37527/2016.66.3.007},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Antioxidant, cytotoxic and alpha-glucosidase inhibition activities from the Mexican berry “Anacahuita” (Cordia boissieri)
AU - Ezequiel Viveros‐Valdez
AU - Carlos Jaramillo-Mora
AU - Azucena Oranday-Cárdenas
AU - Javier Morán‐Martínez
AU - Pilar Carranza‐Rosales
PY - 2026
DA - 2026/10/20
JO - Archivos Latinoamericanos de Nutrición
DO - 10.37527/2016.66.3.007
UR - https://doi.org/10.37527/2016.66.3.007
AB - This study describes the total phenolic and flavonoid content as well as cytotoxic, alpha-glucosidase inhibition and antiradical/antioxidant potential of extracts obtained from the edible fruits of Cordia boissieri, which is widely distributed throughout northeastern Mexico. Phenolic and flavonoid content were evaluated by means of the Folin-Ciocalteu method and aluminum chloride colorimetric assay respectively. The antiradical/antioxidant activity was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Trolox Equivalent Antioxidant Capacity (TEAC) assays. Cytotoxic activity was assessed by means of human cancer cell lines (MCF-7 and HeLa), alpha-glucosidase inhibition was determined by colorimetric assay using p-Nitrophenyl a-D-glucopyranoside (PNPG) as a substrate. Results indicate that extract of C. boissieri fruit has a good antioxidant potential to show a EC₅₀: 137.76 ± 35 ptg/mL and 65 ±2 ltM/g in the DPPH and TEAC assays respectively, inhibitor of the enzyme alpha-glu- cosidase involved in sugar uptake (ICSO: 215.20 ± 35 μg/ mL), cytotoxic activities against MCF-7 (IC50: 310 ± 42 μg/mL) and HeLa (IC₅₀0: 450.4 ±21μgg/mL) cancer cell lines as well as an important phenolic content with 230 t 23 mg/1OOg and 54±11 mg100g g of phenols and flavonoids totals respectively. These results point towards an interesting potential for the fruits of C. boissieri as chemopreventive properties and expand the possibilities.
SN - 0004-0622
SN - 2309-5806
ER -