Depressive Symptoms, Sleep Quality, and Anhedonia in Patients with Primary Biliary Cholangitis: A Cross-Sectional Study
- 1Ümraniye Eğitim ve Araştırma Hastanesi, Ümraniye 34760, Turkey
- 2Department of Child and Adolescent Psychiatry, Faculty of Medicine, Hacettepe University Hospital, Ankara 06100, Turkey
Abstract
Background and aim: This study assessed depressive symptoms, sleep quality, and anhedonia in patients with primary biliary cholangitis (PBC), compared them with healthy controls (HCs), and explored their associations with UDCA treatment response, established prognostic scores, and liver stiffness measurement (LSM) in patients with PBC. Methods: In this single-center cross-sectional study, 103 patients with PBC and 50 HCs were evaluated using three validated patient-reported outcome (PRO) instruments: the Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and Snaith–Hamilton Pleasure Scale (SHAPS). PRO measures were compared between patients with PBC and HCs, and associations between PROs and UDCA treatment response, prognostic scores, and LSM were explored in the PBC group. Results: Moderate-to-severe depressive symptoms, poor sleep quality, and anhedonia were observed in 45%, 62%, and 36% of patients with PBC, respectively, compared with 18%, 38%, and 18% of HCs. The age- and sex-adjusted odds ratios (ORs) for PBCvs. HC were 3.889 (95% CI 1.695–8.926), 3.442 (95% CI 1.636–7.238), and 2.678 (95% CI 1.158–6.193), respectively. Younger age was independently associated with poor sleep quality (OR per year 0.946, 95% CI 0.898–0.997; p = 0.039). No statistically significant associations were identified between PROs and UDCA response, prognostic scores, and LSM in patients with PBC. Conclusions: Patients with PBC reported a substantial and interrelated burden of depressive symptoms, poor sleep quality, and anhedonia compared with HCs.
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BibTeX
@article{saruhan2026depressive,
title = {{Depressive Symptoms, Sleep Quality, and Anhedonia in Patients with Primary Biliary Cholangitis: A Cross-Sectional Study}},
author = {Mehmet Ali Saruhan and Fırat Oyman and Berkay Dertsiz and Kemal Saruhan and Gupse Adali},
journal = {Journal of Clinical Medicine},
year = {2026},
month = oct,
doi = {10.3390/jcm15207967},
url = {https://www.mdpi.com/2077-0383/15/20/7967},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Depressive Symptoms, Sleep Quality, and Anhedonia in Patients with Primary Biliary Cholangitis: A Cross-Sectional Study
AU - Mehmet Ali Saruhan
AU - Fırat Oyman
AU - Berkay Dertsiz
AU - Kemal Saruhan
AU - Gupse Adali
PY - 2026
DA - 2026/10/01
JO - Journal of Clinical Medicine
DO - 10.3390/jcm15207967
UR - https://www.mdpi.com/2077-0383/15/20/7967
AB - Background and aim: This study assessed depressive symptoms, sleep quality, and anhedonia in patients with primary biliary cholangitis (PBC), compared them with healthy controls (HCs), and explored their associations with UDCA treatment response, established prognostic scores, and liver stiffness measurement (LSM) in patients with PBC. Methods: In this single-center cross-sectional study, 103 patients with PBC and 50 HCs were evaluated using three validated patient-reported outcome (PRO) instruments: the Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and Snaith–Hamilton Pleasure Scale (SHAPS). PRO measures were compared between patients with PBC and HCs, and associations between PROs and UDCA treatment response, prognostic scores, and LSM were explored in the PBC group. Results: Moderate-to-severe depressive symptoms, poor sleep quality, and anhedonia were observed in 45%, 62%, and 36% of patients with PBC, respectively, compared with 18%, 38%, and 18% of HCs. The age- and sex-adjusted odds ratios (ORs) for PBCvs. HC were 3.889 (95% CI 1.695–8.926), 3.442 (95% CI 1.636–7.238), and 2.678 (95% CI 1.158–6.193), respectively. Younger age was independently associated with poor sleep quality (OR per year 0.946, 95% CI 0.898–0.997; p = 0.039). No statistically significant associations were identified between PROs and UDCA response, prognostic scores, and LSM in patients with PBC. Conclusions: Patients with PBC reported a substantial and interrelated burden of depressive symptoms, poor sleep quality, and anhedonia compared with HCs.
SN - 2077-0383
ER -