Mucous Membrane Pemphigoid during CPX-351 Therapy Successfully Treated with Corticosteroids

Abstract

A 58-year-old man was diagnosed with acute myeloid leukemia with myelodysplasia-related changes. Induction therapy with CPX-351 achieved complete remission, and a second course of consolidation therapy was administered. Shortly after the second course, he developed aphthous ulcers on the tongue that progressively worsened. Although a tongue biopsy showed no specific findings, serum anti-bullous pemphigoid 180 antibodies were positive. Mucous membrane pemphigoid (MMP) was diagnosed, and corticosteroid therapy led to a rapid improvement. Given the temporal relationship between CPX-351 administration and the MMP onset, CPX-351 was considered to be the likely causative agent.

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BibTeX RIS

BibTeX

@article{akimoto2026mucous,
  title = {{Mucous Membrane Pemphigoid during CPX-351 Therapy Successfully Treated with Corticosteroids}},
  author = {Masahiro Akimoto and Takashi Matsuki and Michiki Saito and Kengo Katsuki and Takayoshi Tachibana and Masatsugu Tanaka and Hideaki Nakajima},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.6829-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6829-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Mucous Membrane Pemphigoid during CPX-351 Therapy Successfully Treated with Corticosteroids
AU  - Masahiro Akimoto
AU  - Takashi Matsuki
AU  - Michiki Saito
AU  - Kengo Katsuki
AU  - Takayoshi Tachibana
AU  - Masatsugu Tanaka
AU  - Hideaki Nakajima
PY  - 2026
DA  - 2026/09/01
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6829-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/17/65_6829-25/_article
AB  - A 58-year-old man was diagnosed with acute myeloid leukemia with myelodysplasia-related changes. Induction therapy with CPX-351 achieved complete remission, and a second course of consolidation therapy was administered. Shortly after the second course, he developed aphthous ulcers on the tongue that progressively worsened. Although a tongue biopsy showed no specific findings, serum anti-bullous pemphigoid 180 antibodies were positive. Mucous membrane pemphigoid (MMP) was diagnosed, and corticosteroid therapy led to a rapid improvement. Given the temporal relationship between CPX-351 administration and the MMP onset, CPX-351 was considered to be the likely causative agent.
SN  - 1349-7235
SN  - 0918-2918
ER  -

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