Peer-reviewedCC BY-NC-NDInternal Medicine
A Case of Insulin Autoimmune Syndrome Complicated by IgG4-Related Disease, Both Successfully Treated with Corticosteroids
Abstract
We present the case of a 73-year-old man diagnosed with insulin autoimmune syndrome (IAS) during an investigation of hypoglycemia. This disease is a rare cause of hypoglycemia induced by autoantibodies against insulin. The patient was diagnosed with IgG4-related disease (IgG4-RD). Moreover, the patient had myelodysplastic syndrome (MDS). We hypothesized that immunological dysregulation driven by MDS may have contributed to the coexistence of these two rare conditions in our patient. Treatment with prednisolone promptly resolved hypoglycemia and improved the disease activity of IgG4-RD. We present this case as, to the best of our knowledge, it is the first peer-reviewed case report of coexisting IAS and IgG4-RD.
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BibTeX
@article{oshima2026case,
title = {{A Case of Insulin Autoimmune Syndrome Complicated by IgG4-Related Disease, Both Successfully Treated with Corticosteroids}},
author = {Yosuke Oshima and Naohiro Saito and Takahisa Kawaguchi and Mikio Okayama and Hiroaki Taguchi and Hideki Orikasa and Takashi Ando},
journal = {Internal Medicine},
year = {2026},
month = oct,
doi = {10.2169/internalmedicine.7479-26},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7479-26/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - A Case of Insulin Autoimmune Syndrome Complicated by IgG4-Related Disease, Both Successfully Treated with Corticosteroids
AU - Yosuke Oshima
AU - Naohiro Saito
AU - Takahisa Kawaguchi
AU - Mikio Okayama
AU - Hiroaki Taguchi
AU - Hideki Orikasa
AU - Takashi Ando
PY - 2026
DA - 2026/10/08
JO - Internal Medicine
DO - 10.2169/internalmedicine.7479-26
UR - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7479-26/_article
AB - We present the case of a 73-year-old man diagnosed with insulin autoimmune syndrome (IAS) during an investigation of hypoglycemia. This disease is a rare cause of hypoglycemia induced by autoantibodies against insulin. The patient was diagnosed with IgG4-related disease (IgG4-RD). Moreover, the patient had myelodysplastic syndrome (MDS). We hypothesized that immunological dysregulation driven by MDS may have contributed to the coexistence of these two rare conditions in our patient. Treatment with prednisolone promptly resolved hypoglycemia and improved the disease activity of IgG4-RD. We present this case as, to the best of our knowledge, it is the first peer-reviewed case report of coexisting IAS and IgG4-RD.
SN - 1349-7235
SN - 0918-2918
ER -