Reproducibility of the Cepstral Spectral Index of Dysphonia in Tracheoesophageal Speech and Exploratory Associations with Clinical Communication Measures.
4 affiliations
- 1Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan, Okinawa 901-2720, Japan.
- 2Division of Head and Neck Surgery, Cancer Institute Hospital, Japanese Foundation of Cancer Research, Tokyo 135-8550, Japan.
- 3Department of Rehabilitation, Cancer Institute Hospital, Japanese Foundation of Cancer Research, Tokyo 135-8550, Japan.
- 4Head and Neck Oncology Center, Showa Medical University, Tokyo 142-8666, Japan.
Abstract
Background/Objectives: The Cepstral Spectral Index of Dysphonia (CSID) was developed for laryngeal dysphonia. We evaluated task-specific reproducibility in tracheoesophageal (TE) speech and associations with communication measures and surgical/anatomical configuration. Methods: Fifty-four habitual TE speakers were prospectively enrolled. Recordings comprised sustained /a:/ and four connected-speech sentences. Repeated analyses used the same recordings with independent resegmentation. Reproducibility was assessed using intraclass correlation coefficients (ICCs), standard error of measurement, and mean absolute percentage difference (MAPD). The Performance Status Scale for Head and Neck Cancer Patients (PSS-HN) speech subscale and a visual analog scale (VAS) assessed comprehensibility and perceived intelligibility, respectively. PSS-HN agreement used Gwet's AC2 with ordinal weights. Spearman correlation tests underwent false-discovery-rate adjustment. Configuration-group comparisons used Kruskal-Wallis tests with Benjamini-Hochberg correction and Bonferroni-adjusted pairwise comparisons. Results: Connected-speech single-measure ICCs were 0.987-0.998 within operator and 0.990-0.996 between raters; MAPDs were 1.02-1.99% and 1.41-2.74%, respectively. Sustained-vowel ICCs were 0.749 and 0.874; MAPDs were 8.12% and 5.26%. PSS-HN within-rater and interrater AC2 values were 0.893 and 0.478, respectively. CSID-VAS correlations were modest (absolute ρ = 0.239-0.468). All five tasks differed across the three configuration groups after correction (all q ≤ 0.033). Across all four connected-speech tasks, CSID was lower with cervical-esophageal prosthesis placement after total laryngectomy than with placement into reconstructed tissue. No sustained-vowel pairwise comparison was significant. Conclusions: Connected-speech CSID showed high reproducibility, whereas sustained-vowel measurements showed greater variability. Configuration-group differences cannot isolate an independent effect of prosthesis insertion site. Associations with broader communication measures remain exploratory. Further TE-specific validation against voice-quality ratings remains necessary.
Related
- Associations Between Upright Cardiovascular-Autonomic Characteristics, Temporal Gait Measures, and Mediolateral Plantar Center-of-Force Measures in Adults with Developmental Disabilities: An Exploratory Cross-Sectional Study
- Restrictive Eating Patterns and Eating Disorder Risk in Female Ballet Dancers: Exploratory Associations with Self-Reported Workplace Bullying and Possible Mobbing
- Quantitative Whole-Leg Radiographic Assessment of Coronal Knee–Ankle Alignment: Associations with Talar Inclination and Exploratory Changes After Knee Osteotomy
- Cytokine Profiles in Cervical Intraepithelial Neoplasia: Associations with Lesion Severity and Exploratory Treatment Response
- Machine-learning phenotyping and exploratory medication-outcome associations in heart failure with preserved ejection fraction: a multicohort retrospective study
BibTeX
@article{kayo2026reproducibility,
title = {{Reproducibility of the Cepstral Spectral Index of Dysphonia in Tracheoesophageal Speech and Exploratory Associations with Clinical Communication Measures.}},
author = {Yuki Kayo and Hitoshi Hirakawa and Shunichi Sugasawa and Sae Imaizumi and Yuiko Kudo and Ryosuke Kamiyama and Hirofumi Fukushima and Hiroki Mitani and Mikio Suzuki},
journal = {Audiology research},
year = {2026},
month = sep,
doi = {10.3390/audiolres16050144},
url = {https://europepmc.org/article/MED/42930342},
note = {CC BY},
}
RIS
TY - JOUR
TI - Reproducibility of the Cepstral Spectral Index of Dysphonia in Tracheoesophageal Speech and Exploratory Associations with Clinical Communication Measures.
AU - Yuki Kayo
AU - Hitoshi Hirakawa
AU - Shunichi Sugasawa
AU - Sae Imaizumi
AU - Yuiko Kudo
AU - Ryosuke Kamiyama
AU - Hirofumi Fukushima
AU - Hiroki Mitani
AU - Mikio Suzuki
PY - 2026
DA - 2026/09/25
JO - Audiology research
DO - 10.3390/audiolres16050144
UR - https://europepmc.org/article/MED/42930342
AB - Background/Objectives: The Cepstral Spectral Index of Dysphonia (CSID) was developed for laryngeal dysphonia. We evaluated task-specific reproducibility in tracheoesophageal (TE) speech and associations with communication measures and surgical/anatomical configuration. Methods: Fifty-four habitual TE speakers were prospectively enrolled. Recordings comprised sustained /a:/ and four connected-speech sentences. Repeated analyses used the same recordings with independent resegmentation. Reproducibility was assessed using intraclass correlation coefficients (ICCs), standard error of measurement, and mean absolute percentage difference (MAPD). The Performance Status Scale for Head and Neck Cancer Patients (PSS-HN) speech subscale and a visual analog scale (VAS) assessed comprehensibility and perceived intelligibility, respectively. PSS-HN agreement used Gwet's AC2 with ordinal weights. Spearman correlation tests underwent false-discovery-rate adjustment. Configuration-group comparisons used Kruskal-Wallis tests with Benjamini-Hochberg correction and Bonferroni-adjusted pairwise comparisons. Results: Connected-speech single-measure ICCs were 0.987-0.998 within operator and 0.990-0.996 between raters; MAPDs were 1.02-1.99% and 1.41-2.74%, respectively. Sustained-vowel ICCs were 0.749 and 0.874; MAPDs were 8.12% and 5.26%. PSS-HN within-rater and interrater AC2 values were 0.893 and 0.478, respectively. CSID-VAS correlations were modest (absolute ρ = 0.239-0.468). All five tasks differed across the three configuration groups after correction (all q ≤ 0.033). Across all four connected-speech tasks, CSID was lower with cervical-esophageal prosthesis placement after total laryngectomy than with placement into reconstructed tissue. No sustained-vowel pairwise comparison was significant. Conclusions: Connected-speech CSID showed high reproducibility, whereas sustained-vowel measurements showed greater variability. Configuration-group differences cannot isolate an independent effect of prosthesis insertion site. Associations with broader communication measures remain exploratory. Further TE-specific validation against voice-quality ratings remains necessary.
SN - 2039-4330
SN - 2039-4349
ER -