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PreprintCC BY-NC-NDChemRxiv

Polyoxometalate-controlled oxidative formation of bioinspired polydopamine hydrogels

  • Paul Kadereit
  • Marius G. Braun
  • Martin Diefenbach
  • Christopher V. Synatschke
  • Vera Krewald
  • Tanja Weil
  • Carsten Streb
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Abstract

Polyoxometalates (POMs) have been extensively explored as enzyme-mimetic catalysts capable of peroxidase-like peroxide-driven reactions. Specifically, transition metal-substituted POMs provide a molecular platform for tunable reactivity and kinetic control. Here, we use a titanium-doped Keggin polyoxomolybdate [(TiOH)PMo11O39]4- {TiOH} to crosslink a dopamine-functionalized alginate hydrogel in the presence of hydrogen peroxide under mild conditions which would otherwise prevent polymer formation. Tuning of the hydrogel rheological properties is possible by molecular-level reaction control. Experimental and theoretical studies are combined for comprehensive insight into the reaction mechanism of the catalytically active species.

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Cite

BibTeXRIS
BibTeX
@misc{kadereit2026polyoxometalatecontrolled,
  title = {{Polyoxometalate-controlled oxidative formation of bioinspired polydopamine hydrogels}},
  author = {Paul Kadereit and Marius G. Braun and Martin Diefenbach and Christopher V. Synatschke and Vera Krewald and Tanja Weil and Carsten Streb},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010928/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010928/v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Polyoxometalate-controlled oxidative formation of bioinspired polydopamine hydrogels
AU  - Paul Kadereit
AU  - Marius G. Braun
AU  - Martin Diefenbach
AU  - Christopher V. Synatschke
AU  - Vera Krewald
AU  - Tanja Weil
AU  - Carsten Streb
PY  - 2026
DA  - 2026/10/23
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010928/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010928/v1
AB  - Polyoxometalates (POMs) have been extensively explored as enzyme-mimetic catalysts capable of peroxidase-like peroxide-driven reactions. Specifically, transition metal-substituted POMs provide a molecular platform for tunable reactivity and kinetic control. Here, we use a titanium-doped Keggin polyoxomolybdate [(TiOH)PMo11O39]4- {TiOH} to crosslink a dopamine-functionalized alginate hydrogel in the presence of hydrogen peroxide under mild conditions which would otherwise prevent polymer formation. Tuning of the hydrogel rheological properties is possible by molecular-level reaction control. Experimental and theoretical studies are combined for comprehensive insight into the reaction mechanism of the catalytically active species.
ER  -