Nanozyme-based biosensors for pathogenic microorganism detection: a mini-review
- 1College of Pharmacy and Bioengineering, Chongqing University of Technology , ,
Abstract
Nanozyme technology has surfaced as a game-changing tool in the detection of pathogenic microorganisms, serving as an appealing substitute for traditional biosensing methods. This review first highlighted the unique catalytic mechanisms of nanozymes, including peroxidase-like, catalase-like, oxidase-like, and superoxide dismutase-like activities, which are fundamental to their usefulness. Second, we explored mainstream biosensing platforms, such as colorimetric/lateral flow assays, electrochemical sensors, fluorescent/dual-modal systems, and nanozyme-CRISPR synergistic approaches. Each of these systems benefited from the stability, tunability, and cost-effectiveness of nanozymes. Third, the applications of nanozyme-based biosensors in the diagnosis of clinical pathogens, the detection of foodborne bacteria, and the monitoring of environmental microorganisms were further analyzed. Finally, the future directions of nanozyme-based biosensors were discussed to advance their clinical and industrial translation.
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BibTeX
@article{yang2026nanozymebased,
title = {{Nanozyme-based biosensors for pathogenic microorganism detection: a mini-review}},
author = {Ting Yang and Yuting Ling and Enmei Zhang and Jin Li},
journal = {Frontiers in microbiology},
year = {2026},
month = sep,
doi = {10.3389/fmicb.2026.1994360},
url = {https://europepmc.org/article/PMC/PMC13662422},
note = {CC BY},
}
RIS
TY - JOUR
TI - Nanozyme-based biosensors for pathogenic microorganism detection: a mini-review
AU - Ting Yang
AU - Yuting Ling
AU - Enmei Zhang
AU - Jin Li
PY - 2026
DA - 2026/09/30
JO - Frontiers in microbiology
DO - 10.3389/fmicb.2026.1994360
UR - https://europepmc.org/article/PMC/PMC13662422
AB - Nanozyme technology has surfaced as a game-changing tool in the detection of pathogenic microorganisms, serving as an appealing substitute for traditional biosensing methods. This review first highlighted the unique catalytic mechanisms of nanozymes, including peroxidase-like, catalase-like, oxidase-like, and superoxide dismutase-like activities, which are fundamental to their usefulness. Second, we explored mainstream biosensing platforms, such as colorimetric/lateral flow assays, electrochemical sensors, fluorescent/dual-modal systems, and nanozyme-CRISPR synergistic approaches. Each of these systems benefited from the stability, tunability, and cost-effectiveness of nanozymes. Third, the applications of nanozyme-based biosensors in the diagnosis of clinical pathogens, the detection of foodborne bacteria, and the monitoring of environmental microorganisms were further analyzed. Finally, the future directions of nanozyme-based biosensors were discussed to advance their clinical and industrial translation.
SN - 1664-302X
ER -