Association of neighborhood deprivation with Alzheimer's disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE ε4 status.
9 affiliations
- 1Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
- 2University of Pompeu Fabra (UPF), Barcelona, Spain.
- 3Sant Pau Memory Unit, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
- 4Rush University Medical Center, Chicago, Illinois, USA.
- 5Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
- 6Houston Methodist Research Institute, Houston, Texas, USA.
- 7Alzheimer's Association, Chicago, Illinois, USA.
- 8Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
- 9University of California, Berkeley, Berkeley, California, USA.
Abstract
Introduction
We investigated associations of Area Deprivation Index (ADI) with Alzheimer's disease (AD) -related outcomes by biological and social factors in at-risk older adults.Methods
A total of 1880 U.S. POINTER participants with ADI and cognition (Preclinical Alzheimer's Cognitive Composite [PACC]) were included. 868 had amyloid, tau positron emission tomography (PET), white matter hyperintensities (WMH), and/or gray matter volumes. We conducted exploratory, linear regression models testing ADI interactions with sex, race and ethnicity, and apolipoprotein E (APOE) ε4, adjusting for age and education.Results
"White/European American" and "Hispanic/Latinx/Spanish" showed lower cognitive scores with higher ADI, while "White/European American" showed the highest cognitive scores across ADI levels. APOE ε4 carriers from high-ADI areas showed higher WMH and tau, and "Hispanic/Latinx/Spanish" from more deprived areas showed higher WMH. Females from moderate-ADI areas showed higher tau. Amyloid burden was higher among low-ADI APOE ε4 carriers.Discussion
Differential associations of ADI with AD-related outcomes across biological and social factors may reflect systemic health disparities and study design.
Related
- Maternal neighborhood deprivation and its association with early childhood neurodevelopmental impairment in extremely preterm infants
- Neighborhood socioeconomic deprivation is associated with worse cognitive performance and in vivo amyloid accumulation.
- Association between hypertension prevalence and neighborhood characteristics in Japan using combined claims data and geographic information systems: a neighborhood correlation study from LIFE Study
- Characterizing the association of neighborhood built-environment and type 2 diabetes-related clinical health outcomes: insights from the All of Us Research Program
- Association of neighborhood social vulnerability with cigarette dependence and abstinence in patients with cancer who smoke
BibTeX
@article{aguilardominguez2026association,
title = {{Association of neighborhood deprivation with Alzheimer's disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE ε4 status.}},
author = {Pablo Aguilar-Dominguez and Carmen-Maria Colceriu and Thomas Monroe Holland and Samuel N Lockhart and Joseph C Masdeu and Lycia Tramujas Vasconcellos Neumann and Heather M Snyder and Laura D Baker and Alexandre Bejanin and Susan M Landau and Eider M Arenaza-Urquijo},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = oct,
doi = {10.1002/alz.71929},
url = {https://europepmc.org/article/MED/42967602},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Association of neighborhood deprivation with Alzheimer's disease pathology, brain structure, and cognition by race and ethnicity, sex, and APOE ε4 status.
AU - Pablo Aguilar-Dominguez
AU - Carmen-Maria Colceriu
AU - Thomas Monroe Holland
AU - Samuel N Lockhart
AU - Joseph C Masdeu
AU - Lycia Tramujas Vasconcellos Neumann
AU - Heather M Snyder
AU - Laura D Baker
AU - Alexandre Bejanin
AU - Susan M Landau
AU - Eider M Arenaza-Urquijo
PY - 2026
DA - 2026/10/01
JO - Alzheimer's & dementia : the journal of the Alzheimer's Association
DO - 10.1002/alz.71929
UR - https://europepmc.org/article/MED/42967602
AB - Introduction We investigated associations of Area Deprivation Index (ADI) with Alzheimer's disease (AD) -related outcomes by biological and social factors in at-risk older adults.Methods A total of 1880 U.S. POINTER participants with ADI and cognition (Preclinical Alzheimer's Cognitive Composite [PACC]) were included. 868 had amyloid, tau positron emission tomography (PET), white matter hyperintensities (WMH), and/or gray matter volumes. We conducted exploratory, linear regression models testing ADI interactions with sex, race and ethnicity, and apolipoprotein E (APOE) ε4, adjusting for age and education.Results "White/European American" and "Hispanic/Latinx/Spanish" showed lower cognitive scores with higher ADI, while "White/European American" showed the highest cognitive scores across ADI levels. APOE ε4 carriers from high-ADI areas showed higher WMH and tau, and "Hispanic/Latinx/Spanish" from more deprived areas showed higher WMH. Females from moderate-ADI areas showed higher tau. Amyloid burden was higher among low-ADI APOE ε4 carriers.Discussion Differential associations of ADI with AD-related outcomes across biological and social factors may reflect systemic health disparities and study design.
SN - 1552-5260
SN - 1552-5279
ER -