Advances in Indocyanine Green Near-Infrared Fluorescence for Extrahepatic Biliary Identification in Laparoscopic Cholecystectomy for Acute Cholecystitis: A Narrative Review.
5 affiliations
- 1Affiliated Baotou Clinical College of Inner Mongolia Medical University, Baotou, Inner Mongolia, China.
- 2Hepatobiliary Surgery Department, Baotou Central Hospital, Baotou, Inner Mongolia, China.
- 3National Key Clinical Specialty Development Project (General Surgery), Baotou Central Hospital, Baotou, Inner Mongolia, China.
- 4Graduate School, Baotou Medical College, Baotou, Inner Mongolia, China.
- 5The Third Affiliated Hospital of Inner Mongolia Medical University, Baotou, Inner Mongolia, China.
Abstract
Laparoscopic cholecystectomy, a minimally invasive procedure with rapid recovery, remains the standard surgical intervention for acute cholecystitis. Acute inflammation of the gallbladder can cause severe edema, dense adhesions, and anatomical distortion within Calot's triangle, frequently obscuring tissue planes and increasing the risk of iatrogenic bile duct injury, a significant surgical complication. Indocyanine green fluorescence serves as a valuable intraoperative navigation tool. Its hepatobiliary metabolic characteristics enable real-time near-infrared visualization of extrahepatic bile ducts, thereby compensating for the limitations of visual and tactile identification during routine cholecystectomy. This narrative review compiles published clinical evidence regarding the application of indocyanine green fluorescence in acute cholecystitis operations. We summarize its advantages in inflamed operative fields and categorize practical application experiences across varying grades of inflammation. Current data indicate enhanced biliary visualization and reduced operative time; however, robust high-level trials confirming a reduction in bile duct injury risks remain lacking. Additionally, we discuss emerging technical advancements, such as artificial intelligence and multispectral imaging. This article aims to evaluate the practical value of indocyanine green near-infrared fluorescence for the recognition of extrahepatic bile ducts in laparoscopic cholecystectomy performed on patients with acute cholecystitis.
Related
- Real-time Visualisation of the Extrahepatic Biliary System Using Indocyanine Green Fluorescence Cholangiography During Laparoscopic Cholecystectomy: A Prospective Cross-sectional Single-centre Study of 199 Cases
- Development and Internal Validation of a Preoperative Risk Stratification Model for Difficult Laparoscopic Cholecystectomy in Acute Cholecystitis
- Association of Serum Ferritin and Cytokine Profile With Severity of Acute Cholecystitis in Patients Undergoing Laparoscopic Cholecystectomy
- Optimizing Indocyanine Green Fluorescence Cholangiography in Laparoscopic Cholecystectomy: A Systematic Review of Randomized Controlled Trials on Dose, Timing, Route, Efficacy, and Safety
- Factors associated with prolonged postoperative hospital stay after cholecystectomy for acute cholecystitis in a Peruvian emergency hospital.
BibTeX
@article{jin2026advances,
title = {{Advances in Indocyanine Green Near-Infrared Fluorescence for Extrahepatic Biliary Identification in Laparoscopic Cholecystectomy for Acute Cholecystitis: A Narrative Review.}},
author = {Zhihui Jin and Xusheng Yang and Yuntian Liu and Lei Song and Xuewen Chen and Yue Wang and Xiaoping Cheng and Lu Liang and Bihui Yao},
journal = {Medical science monitor : international medical journal of experimental and clinical research},
year = {2026},
month = oct,
doi = {10.12659/msm.953667},
url = {https://europepmc.org/article/MED/42839553},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Advances in Indocyanine Green Near-Infrared Fluorescence for Extrahepatic Biliary Identification in Laparoscopic Cholecystectomy for Acute Cholecystitis: A Narrative Review.
AU - Zhihui Jin
AU - Xusheng Yang
AU - Yuntian Liu
AU - Lei Song
AU - Xuewen Chen
AU - Yue Wang
AU - Xiaoping Cheng
AU - Lu Liang
AU - Bihui Yao
PY - 2026
DA - 2026/10/07
JO - Medical science monitor : international medical journal of experimental and clinical research
DO - 10.12659/msm.953667
UR - https://europepmc.org/article/MED/42839553
AB - Laparoscopic cholecystectomy, a minimally invasive procedure with rapid recovery, remains the standard surgical intervention for acute cholecystitis. Acute inflammation of the gallbladder can cause severe edema, dense adhesions, and anatomical distortion within Calot's triangle, frequently obscuring tissue planes and increasing the risk of iatrogenic bile duct injury, a significant surgical complication. Indocyanine green fluorescence serves as a valuable intraoperative navigation tool. Its hepatobiliary metabolic characteristics enable real-time near-infrared visualization of extrahepatic bile ducts, thereby compensating for the limitations of visual and tactile identification during routine cholecystectomy. This narrative review compiles published clinical evidence regarding the application of indocyanine green fluorescence in acute cholecystitis operations. We summarize its advantages in inflamed operative fields and categorize practical application experiences across varying grades of inflammation. Current data indicate enhanced biliary visualization and reduced operative time; however, robust high-level trials confirming a reduction in bile duct injury risks remain lacking. Additionally, we discuss emerging technical advancements, such as artificial intelligence and multispectral imaging. This article aims to evaluate the practical value of indocyanine green near-infrared fluorescence for the recognition of extrahepatic bile ducts in laparoscopic cholecystectomy performed on patients with acute cholecystitis.
SN - 1234-1010
SN - 1643-3750
ER -