Predictors, prevalence and economic burden of depression and anxiety in Vietnam and comparable lower-middle-income countries in Southeast Asia: protocol for an integrative review
4 affiliations
- 1College of Health Sciences, VinUniversity, Hanoi, Vietnam
- 2Vinmec International Hospital, Hanoi, Vietnam
- 3Innovations in Health Sciences, VinUniversity, Hanoi, Vietnam
- 4National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
Abstract
Introduction: Depression and anxiety disorders are leading contributors to global disability and economic burden. In Vietnam, current national evidence on prevalence and economic burden is limited and fragmented. This integrative review aims to synthesise evidence on the prevalence, economic burden, determinants and health-system responses to depression and anxiety in Vietnam and comparable lower-middle-income countries in Southeast Asia, to inform Vietnam’s planned national survey.
Methods and analysis: The review will follow the integrative review methodology of Toronto and Remington and Whittemore and Knafl. MEDLINE (Ovid), CINAHL (EBSCOhost), EMBASE (Ovid), PsycINFO (Ovid) and grey-literature sources will be searched from January 2010 to the final search date; foundational methodological/theoretical literature will not be date restricted. Electronic database searches will be restricted to English-language records; eligible Vietnamese-language institutional grey literature will be translated. Eligible sources will include peer-reviewed and grey literature, empirical studies of any design, systematic reviews and theoretical literature addressing the review questions in adults (≥18 years) in Vietnam or other lower-middle-income countries in Southeast Asia. Studies limited to children, severe mental illness without depression or anxiety or non-data-based publications will be excluded. Two reviewers will independently screen and appraise sources using the Mixed Methods Appraisal Tool. Data will be analysed using constant comparison.
Ethics and dissemination: This review uses published literature and requires no ethical approval. Findings will be disseminated through peer-reviewed publication, conferences, a plain-language summary for Vietnamese stakeholders and deposit of extraction matrices and synthesis outputs in the Open Science Framework repository.
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BibTeX
@article{donnelly2026predictors,
title = {{Predictors, prevalence and economic burden of depression and anxiety in Vietnam and comparable lower-middle-income countries in Southeast Asia: protocol for an integrative review}},
author = {Tam Truong Donnelly and Thanh Phuong Vu and Thi My Hanh Nguyen and Quynh Giang Nguyen and Ngoc Khoi Tran and Huu Hoai Bao Le and Dieu Minh Tang},
journal = {BMJ Open},
year = {2026},
month = oct,
doi = {10.1136/bmjopen-2026-125645},
url = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2026-125645},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Predictors, prevalence and economic burden of depression and anxiety in Vietnam and comparable lower-middle-income countries in Southeast Asia: protocol for an integrative review
AU - Tam Truong Donnelly
AU - Thanh Phuong Vu
AU - Thi My Hanh Nguyen
AU - Quynh Giang Nguyen
AU - Ngoc Khoi Tran
AU - Huu Hoai Bao Le
AU - Dieu Minh Tang
PY - 2026
DA - 2026/10/29
JO - BMJ Open
DO - 10.1136/bmjopen-2026-125645
UR - https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2026-125645
AB - Introduction: Depression and anxiety disorders are leading contributors to global disability and economic burden. In Vietnam, current national evidence on prevalence and economic burden is limited and fragmented. This integrative review aims to synthesise evidence on the prevalence, economic burden, determinants and health-system responses to depression and anxiety in Vietnam and comparable lower-middle-income countries in Southeast Asia, to inform Vietnam’s planned national survey. Methods and analysis: The review will follow the integrative review methodology of Toronto and Remington and Whittemore and Knafl. MEDLINE (Ovid), CINAHL (EBSCOhost), EMBASE (Ovid), PsycINFO (Ovid) and grey-literature sources will be searched from January 2010 to the final search date; foundational methodological/theoretical literature will not be date restricted. Electronic database searches will be restricted to English-language records; eligible Vietnamese-language institutional grey literature will be translated. Eligible sources will include peer-reviewed and grey literature, empirical studies of any design, systematic reviews and theoretical literature addressing the review questions in adults (≥18 years) in Vietnam or other lower-middle-income countries in Southeast Asia. Studies limited to children, severe mental illness without depression or anxiety or non-data-based publications will be excluded. Two reviewers will independently screen and appraise sources using the Mixed Methods Appraisal Tool. Data will be analysed using constant comparison. Ethics and dissemination: This review uses published literature and requires no ethical approval. Findings will be disseminated through peer-reviewed publication, conferences, a plain-language summary for Vietnamese stakeholders and deposit of extraction matrices and synthesis outputs in the Open Science Framework repository.
SN - 2044-6055
SN - 2044-6055
ER -