Spatially programmed MOF-coated microchannels for capillary-driven microvolume analysis
- 1Tata Institute of Fundamental Research Hyderabad
Abstract
Metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) offer chemically and geometrically programmable pore environments that have been exploited as coatings for capillary- and fiber-based microextraction. However, most formats still rely on discrete adsorbent handling or external fluid actuation, poorly suited to the microliter sample volumes typical of biological specimens. Here we report glass microcapillaries bearing a spatially programmed, nanometer-thick MOF film that simultaneously drives fluid uptake by capillary action and performs localized analyte enrichment within a single, self-contained channel. Retaining the adsorbent as a conformal film rather than a particulate phase removes the need for separate adsorbent handling. It also concentrates chemical functionality at the fluid-contacting surface, enabling efficient enrichment from a few microliters without external pumps. We demonstrate this approach by enriching and quantifying the inflammation-associated metabolites kynurenine and quinolinic acid from microliter volumes of mouse blood serum, achieving clear discrimination between inflammatory and control conditions. These MOF-coated microcapillaries offer an integrated route to low-volume biofluid analysis in settings where sample availability and external fluid handling are limiting.
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BibTeX
@misc{baisakhi2026spatially,
title = {{Spatially programmed MOF-coated microchannels for capillary-driven microvolume analysis}},
author = {Tilottoma Baisakhi and Archana Yadav and Rajarshi Ghosh and Shruthi Rajaram and Aneesh Tazhe Veetil and Ritesh Haldar},
howpublished = {ChemRxiv},
year = {2026},
month = oct,
doi = {10.26434/chemrxiv.15009956/v1},
url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009956/v1},
note = {CC BY-NC-ND},
}
RIS
TY - UNPB
TI - Spatially programmed MOF-coated microchannels for capillary-driven microvolume analysis
AU - Tilottoma Baisakhi
AU - Archana Yadav
AU - Rajarshi Ghosh
AU - Shruthi Rajaram
AU - Aneesh Tazhe Veetil
AU - Ritesh Haldar
PY - 2026
DA - 2026/10/05
PB - ChemRxiv
DO - 10.26434/chemrxiv.15009956/v1
UR - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009956/v1
AB - Metal–organic frameworks (MOFs) and covalent organic frameworks (COFs) offer chemically and geometrically programmable pore environments that have been exploited as coatings for capillary- and fiber-based microextraction. However, most formats still rely on discrete adsorbent handling or external fluid actuation, poorly suited to the microliter sample volumes typical of biological specimens. Here we report glass microcapillaries bearing a spatially programmed, nanometer-thick MOF film that simultaneously drives fluid uptake by capillary action and performs localized analyte enrichment within a single, self-contained channel. Retaining the adsorbent as a conformal film rather than a particulate phase removes the need for separate adsorbent handling. It also concentrates chemical functionality at the fluid-contacting surface, enabling efficient enrichment from a few microliters without external pumps. We demonstrate this approach by enriching and quantifying the inflammation-associated metabolites kynurenine and quinolinic acid from microliter volumes of mouse blood serum, achieving clear discrimination between inflammatory and control conditions. These MOF-coated microcapillaries offer an integrated route to low-volume biofluid analysis in settings where sample availability and external fluid handling are limiting.
ER -