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Peer-reviewedCC BY 4.0Cancers

Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS)-Based Non-Contrast Breast MRI Screening: Initial Real-World Outcomes of a Non-Population-Based Program

  • Taiyo Leopoldo Harada1
  • Taro Takahara2,3
  • Kazuaki Nakashima1
  • Makoto Mikami4
  • Takashi Sugino5
  • Seiichirou Nishimura6
  • Kaoru Takahashi6
  • Takayoshi Uematsu1
6 affiliations
  1. 1Division of Breast Imaging and Breast Interventional Radiology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan
  2. 2Takahara Clinic Innovative Scan, 3-20-19 Miyasaka, Setagaya-ku, Tokyo 156-0051, Japan
  3. 3Faculty of Medicine, Institute of Science Tokyo, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan
  4. 4Mikami Clinic, Shimizu-ku, Shizuoka 424-0113, Japan
  5. 5Division of Pathology, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan
  6. 6Division of Breast Surgery, Shizuoka Cancer Center Hospital, Shizuoka 411-8777, Japan
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Abstract

Background/Objectives: Mammography screening is limited by low sensitivity in dense breasts and by low participation, partly because of compression-related pain. We report the initial real-world outcomes of a non-population-based (opportunistic), non-contrast, compression-free breast cancer screening program based on DWIBS (DWIBS-BCS), distinguishing initial (prevalence) from subsequent screening. Methods: We retrospectively analyzed DWIBS-BCS examinations performed at a single center from January 2021 to December 2023, excluding examinations in women reporting a palpable lump. Two radiologists assigned four categories; category D was referred for diagnostic follow-up, and categories A–C were not systematically verified. Recall rate (RR), diagnostic follow-up completion rate (DFR), cancer detection rate (CDR), and positive predictive value (PPV) were calculated per examination with exact 95% confidence intervals (CIs) for initial, subsequent, and overall screening. Results: Of 554 DWIBS-BCS examinations, 506 were eligible: 360 initial (360 women) and 146 subsequent (107 women). All six screen-detected cancers occurred at initial screening. At initial screening, RR was 6.1% (22/360; 95% CI, 3.9–9.1%), DFR 81.8% (18/22; 95% CI, 59.7–94.8%), CDR 1.7% (6/360; 16.7 per 1000 examinations; 95% CI, 0.6–3.6%), and PPV 33.3% (6/18; 95% CI, 13.3–59.0%). No cancer was detected among 146 subsequent examinations. Five of the six screen-detected cancers were clinical stage 0 or I. In 36.8% (186/506) of examinations, the woman had never had mammography. Conclusions: In this self-selected cohort with incomplete outcome ascertainment, DWIBS-BCS detected six mostly early-stage cancers at initial screening. These preliminary, descriptive data are not comparable with organized-screening benchmarks and do not establish screening accuracy or clinical benefit; prospective studies with systematic outcome ascertainment are needed.

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Cite

BibTeXRIS
BibTeX
@article{harada2026diffusionweighted,
  title = {{Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS)-Based Non-Contrast Breast MRI Screening: Initial Real-World Outcomes of a Non-Population-Based Program}},
  author = {Taiyo Leopoldo Harada and Taro Takahara and Kazuaki Nakashima and Makoto Mikami and Takashi Sugino and Seiichirou Nishimura and Kaoru Takahashi and Takayoshi Uematsu},
  journal = {Cancers},
  year = {2026},
  month = oct,
  doi = {10.3390/cancers18213417},
  url = {https://www.mdpi.com/2072-6694/18/21/3417},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS)-Based Non-Contrast Breast MRI Screening: Initial Real-World Outcomes of a Non-Population-Based Program
AU  - Taiyo Leopoldo Harada
AU  - Taro Takahara
AU  - Kazuaki Nakashima
AU  - Makoto Mikami
AU  - Takashi Sugino
AU  - Seiichirou Nishimura
AU  - Kaoru Takahashi
AU  - Takayoshi Uematsu
PY  - 2026
DA  - 2026/10/22
JO  - Cancers
DO  - 10.3390/cancers18213417
UR  - https://www.mdpi.com/2072-6694/18/21/3417
AB  - Background/Objectives: Mammography screening is limited by low sensitivity in dense breasts and by low participation, partly because of compression-related pain. We report the initial real-world outcomes of a non-population-based (opportunistic), non-contrast, compression-free breast cancer screening program based on DWIBS (DWIBS-BCS), distinguishing initial (prevalence) from subsequent screening. Methods: We retrospectively analyzed DWIBS-BCS examinations performed at a single center from January 2021 to December 2023, excluding examinations in women reporting a palpable lump. Two radiologists assigned four categories; category D was referred for diagnostic follow-up, and categories A–C were not systematically verified. Recall rate (RR), diagnostic follow-up completion rate (DFR), cancer detection rate (CDR), and positive predictive value (PPV) were calculated per examination with exact 95% confidence intervals (CIs) for initial, subsequent, and overall screening. Results: Of 554 DWIBS-BCS examinations, 506 were eligible: 360 initial (360 women) and 146 subsequent (107 women). All six screen-detected cancers occurred at initial screening. At initial screening, RR was 6.1% (22/360; 95% CI, 3.9–9.1%), DFR 81.8% (18/22; 95% CI, 59.7–94.8%), CDR 1.7% (6/360; 16.7 per 1000 examinations; 95% CI, 0.6–3.6%), and PPV 33.3% (6/18; 95% CI, 13.3–59.0%). No cancer was detected among 146 subsequent examinations. Five of the six screen-detected cancers were clinical stage 0 or I. In 36.8% (186/506) of examinations, the woman had never had mammography. Conclusions: In this self-selected cohort with incomplete outcome ascertainment, DWIBS-BCS detected six mostly early-stage cancers at initial screening. These preliminary, descriptive data are not comparable with organized-screening benchmarks and do not establish screening accuracy or clinical benefit; prospective studies with systematic outcome ascertainment are needed.
SN  - 2072-6694
ER  -