Sex- and the age-specific survival impacts of multiple body composition parameters in patients with gastroesophageal cancers
- 1Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113- 8655 Japan
- 2Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
- 3Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Abstract
Purpose: This study aimed to evaluate the sex- and age-specific survival impacts of body composition (BC) parameters in patients with surgically treated gastroesophageal cancer.
Methods: A total of 1382 patients were retrospectively analyzed. The skeletal muscle index (SMI), skeletal muscle radiodensity (SMD), and visceral/subcutaneous adipose tissue index (VATI/SATI) were determined. The survival impacts of the BC parameters were investigated according to age (≥ 75 or < 75 years) and sex. Multivariate Cox hazard models were used to identify independent predictors of a poor overall survival (OS) and cancer-specific survival (CSS).
Results: The median age was 67 years, and 1028 (74.4%) patients were male. A low SMI (P < 0.001), a low SATI (P = 0.048), and a low SMD (P = 0.01) were independent predictors of poor OS in younger patients; however, only a low SMI (P < 0.001) had an independent impact on OS in the older group. In male patients, all four BC measures significantly demarcated OS curves (all P < 0.01), and a low SMI had an independent impact on CSS (P = 0.03). In contrast, in female patients, only SMI and SATI reliably discriminated OS curves (both P < 0.001), and a low SATI was an independent predictor of a poor CSS (P = 0.008).
Conclusions: The prognostic implications of the BC parameters may vary by age and sex in patients with gastroesophageal cancer.
Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00595-026-03458-y.
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BibTeX
@article{sugawara2026agespecific,
title = {{Sex- and the age-specific survival impacts of multiple body composition parameters in patients with gastroesophageal cancers}},
author = {Kotaro Sugawara and Shinichiro Shiomi and Wataru Gonoi and Satoru Taguchi and Shouhei Hanaoka and Koichi Yagi and Osamu Abe and Haruki Kume and Yoshifumi Baba},
journal = {Surgery Today},
year = {2026},
month = aug,
doi = {10.1007/s00595-026-03458-y},
url = {https://doi.org/10.1007/s00595-026-03458-y},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Sex- and the age-specific survival impacts of multiple body composition parameters in patients with gastroesophageal cancers
AU - Kotaro Sugawara
AU - Shinichiro Shiomi
AU - Wataru Gonoi
AU - Satoru Taguchi
AU - Shouhei Hanaoka
AU - Koichi Yagi
AU - Osamu Abe
AU - Haruki Kume
AU - Yoshifumi Baba
PY - 2026
DA - 2026/08/07
JO - Surgery Today
DO - 10.1007/s00595-026-03458-y
UR - https://doi.org/10.1007/s00595-026-03458-y
AB - Purpose: This study aimed to evaluate the sex- and age-specific survival impacts of body composition (BC) parameters in patients with surgically treated gastroesophageal cancer. Methods: A total of 1382 patients were retrospectively analyzed. The skeletal muscle index (SMI), skeletal muscle radiodensity (SMD), and visceral/subcutaneous adipose tissue index (VATI/SATI) were determined. The survival impacts of the BC parameters were investigated according to age (≥ 75 or < 75 years) and sex. Multivariate Cox hazard models were used to identify independent predictors of a poor overall survival (OS) and cancer-specific survival (CSS). Results: The median age was 67 years, and 1028 (74.4%) patients were male. A low SMI (P < 0.001), a low SATI (P = 0.048), and a low SMD (P = 0.01) were independent predictors of poor OS in younger patients; however, only a low SMI (P < 0.001) had an independent impact on OS in the older group. In male patients, all four BC measures significantly demarcated OS curves (all P < 0.01), and a low SMI had an independent impact on CSS (P = 0.03). In contrast, in female patients, only SMI and SATI reliably discriminated OS curves (both P < 0.001), and a low SATI was an independent predictor of a poor CSS (P = 0.008). Conclusions: The prognostic implications of the BC parameters may vary by age and sex in patients with gastroesophageal cancer. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00595-026-03458-y.
SN - 0941-1291
SN - 1436-2813
ER -