Ocular Myasthenia Gravis Unmasking Molecularly High-Risk but Clinically Indolent Chronic Lymphocytic Leukemia: A Case Report
Abstract
Introduction We report a patient who presented with acute-onset diplopia and fatigable ptosis, subsequently diagnosed with Myasthenia Gravis based on elevated acetylcholine receptor antibodies. Neuroimaging and chest imaging were unremarkable, excluding structural causes and thymoma. Case Presentation During evaluation, persistent lymphocytosis prompted further hematologic workup, which confirmed early-stage Chronic Lymphocytic Leukemia with trisomy 12 and a TP53 mutation. The patient received pyridostigmine and a tapering course of corticosteroids, resulting in rapid clinical improvement and complete resolution of ocular symptoms. The leukemia remained asymptomatic and was managed conservatively with a watchful waiting approach. The clinical course was favorable with sustained remission of myasthenia gravis off therapy and stable hematologic parameters on follow-up. Conclusion This case highlights the diagnostic interplay between autoimmune and lymphoproliferative disorders and underscores the importance of a multidisciplinary approach in managing such overlapping clinical entities.
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BibTeX
@article{khalid2026ocular,
title = {{Ocular Myasthenia Gravis Unmasking Molecularly High-Risk but Clinically Indolent Chronic Lymphocytic Leukemia: A Case Report}},
author = {Haider Bin Khalid and Muhammad Furqan and Zain Ul Abedin and Mehwish Saleem and Mata-e-Alla Dogar and Maryam Saqib and Sadia Binte Rahim and Muhammad Usman Haider and Shaik Abdul Samad Shaik Abdul Rashid},
journal = {Clinical Medicine Insights: Case Reports},
year = {2026},
month = oct,
doi = {10.1177/11795476261502619},
url = {https://doi.org/10.1177/11795476261502619},
note = {CC BY},
}
RIS
TY - JOUR
TI - Ocular Myasthenia Gravis Unmasking Molecularly High-Risk but Clinically Indolent Chronic Lymphocytic Leukemia: A Case Report
AU - Haider Bin Khalid
AU - Muhammad Furqan
AU - Zain Ul Abedin
AU - Mehwish Saleem
AU - Mata-e-Alla Dogar
AU - Maryam Saqib
AU - Sadia Binte Rahim
AU - Muhammad Usman Haider
AU - Shaik Abdul Samad Shaik Abdul Rashid
PY - 2026
DA - 2026/10/23
JO - Clinical Medicine Insights: Case Reports
DO - 10.1177/11795476261502619
UR - https://doi.org/10.1177/11795476261502619
AB - Introduction We report a patient who presented with acute-onset diplopia and fatigable ptosis, subsequently diagnosed with Myasthenia Gravis based on elevated acetylcholine receptor antibodies. Neuroimaging and chest imaging were unremarkable, excluding structural causes and thymoma. Case Presentation During evaluation, persistent lymphocytosis prompted further hematologic workup, which confirmed early-stage Chronic Lymphocytic Leukemia with trisomy 12 and a TP53 mutation. The patient received pyridostigmine and a tapering course of corticosteroids, resulting in rapid clinical improvement and complete resolution of ocular symptoms. The leukemia remained asymptomatic and was managed conservatively with a watchful waiting approach. The clinical course was favorable with sustained remission of myasthenia gravis off therapy and stable hematologic parameters on follow-up. Conclusion This case highlights the diagnostic interplay between autoimmune and lymphoproliferative disorders and underscores the importance of a multidisciplinary approach in managing such overlapping clinical entities.
SN - 1179-5476
ER -