Multipoint Defocus Optics Technology Spectacle Lenses for Myopia Control in Children: A One-Year Interim Analysis of a Randomized Trial.
4 affiliations
- 1Optics Valley Laboratory, Wuhan, China.
- 2School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
- 3Research Centre for SHARP Vision, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
- 4Centre for Eye and Vision Research, Hong Kong, China.
Abstract
Purpose
To evaluate the one-year efficacy of novel partition multipoint defocus optics technology (PMDOT) lenses in slowing myopia progression, compared to lenses with highly aspherical lenslets (HAL).Methods
This is a 1-year interim analysis of an ongoing 2-year, non-inferiority randomized controlled trial, in which 194 children ages 8 to 13 years with spherical equivalent refraction (SER) of -0.75 to -4.5 diopters (D) were randomized to either the PMDOT or HAL group. The primary outcome of the full trial was the mean between-group difference in SER change at 2 years, and the non-inferiority margin was -0.3 D. Secondary outcomes included changes in axial length (AL), choroidal thickness (ChT), and other biometric parameters, as well as best-corrected visual acuity (BCVA) at 2 years and subjective visual experience. Data from right eyes were used for the current analysis.Results
The study included 102 children in the PMDOT group and 92 in the HAL group. After 1 year, the mean ± SD changes in SER and AL were not statistically significantly different between the two groups (PMDOT vs. HAL SER -0.74 ± 0.49 D vs. -0.60 ± 0.48 D, AL 0.26 ± 0.20 mm vs. 0.19 ± 0.19 mm) based on per-protocol (PP) analysis. The between-group difference in SER change at 12 months was -0.09 D (two-sided 97% confidence interval [CI], -0.26 to 0.09). Except for the change in anterior chamber depth in the PP analysis, no significant between-group differences were observed for any secondary outcomes.Conclusions
PMDOT lenses were not inferior to HAL lenses in controlling myopia progression.Translational relevance
This trial demonstrated the clinical potential of PMDOT lenses for myopia control in schoolchildren.
Related
- Adjunctive 0.05% Atropine for Children with Continued Rapid Myopia Progression During Defocus Incorporated Multiple Segments Spectacle Lens Treatment: A Retrospective Matched Cohort Study
- Twelve-Month Efficacy and Visual Tolerability of MyoPi Spectacle Lenses in Childhood Myopia : A Randomized Clinical Trial
- Effect of Peripheral Defocus Contact Lens Residual Decentration After Six Months of Wear on the Astigmatic Component in Myopic Children
- A novel progressive defocus rigid gas permeable contact lenses for controlling axial elongation in myopic children: a retrospective study
- Effectiveness of spectacle lenses with highly aspherical lenslets (HAL) in slowing axial elongation and spherical equivalent refraction progression in myopic and pre-myopic children: a systematic review and meta-analysis.
BibTeX
@article{zhang2026multipoint,
title = {{Multipoint Defocus Optics Technology Spectacle Lenses for Myopia Control in Children: A One-Year Interim Analysis of a Randomized Trial.}},
author = {Yurui Zhang and Xiaotong Han and Ling Jin and Yi Ding and Decai Wang and Mingguang He and YangFa Zeng},
journal = {Translational vision science \& technology},
year = {2026},
month = oct,
doi = {10.1167/tvst.15.10.14},
url = {https://europepmc.org/article/MED/42867309},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Multipoint Defocus Optics Technology Spectacle Lenses for Myopia Control in Children: A One-Year Interim Analysis of a Randomized Trial.
AU - Yurui Zhang
AU - Xiaotong Han
AU - Ling Jin
AU - Yi Ding
AU - Decai Wang
AU - Mingguang He
AU - YangFa Zeng
PY - 2026
DA - 2026/10/01
JO - Translational vision science & technology
DO - 10.1167/tvst.15.10.14
UR - https://europepmc.org/article/MED/42867309
AB - Purpose To evaluate the one-year efficacy of novel partition multipoint defocus optics technology (PMDOT) lenses in slowing myopia progression, compared to lenses with highly aspherical lenslets (HAL).Methods This is a 1-year interim analysis of an ongoing 2-year, non-inferiority randomized controlled trial, in which 194 children ages 8 to 13 years with spherical equivalent refraction (SER) of -0.75 to -4.5 diopters (D) were randomized to either the PMDOT or HAL group. The primary outcome of the full trial was the mean between-group difference in SER change at 2 years, and the non-inferiority margin was -0.3 D. Secondary outcomes included changes in axial length (AL), choroidal thickness (ChT), and other biometric parameters, as well as best-corrected visual acuity (BCVA) at 2 years and subjective visual experience. Data from right eyes were used for the current analysis.Results The study included 102 children in the PMDOT group and 92 in the HAL group. After 1 year, the mean ± SD changes in SER and AL were not statistically significantly different between the two groups (PMDOT vs. HAL SER -0.74 ± 0.49 D vs. -0.60 ± 0.48 D, AL 0.26 ± 0.20 mm vs. 0.19 ± 0.19 mm) based on per-protocol (PP) analysis. The between-group difference in SER change at 12 months was -0.09 D (two-sided 97% confidence interval [CI], -0.26 to 0.09). Except for the change in anterior chamber depth in the PP analysis, no significant between-group differences were observed for any secondary outcomes.Conclusions PMDOT lenses were not inferior to HAL lenses in controlling myopia progression.Translational relevance This trial demonstrated the clinical potential of PMDOT lenses for myopia control in schoolchildren.
SN - 2164-2591
ER -