Differential risk and protective factors for conventional adenomas and serrated lesions: implications for colorectal cancer prevention
- 1Department of Epidemiology and Biostatistics, School of Public Health and Nursing, Hangzhou Normal University
- 2Department of Nutrition and Toxicology, School of Public Health and Nursing, Hangzhou Normal University
Abstract
Conventional adenomas and serrated lesions are two major precursor lesions of colorectal cancer. They arise through distinct carcinogenic pathways, namely the conventional adenoma–carcinoma sequence and the serrated neoplasia pathway. These pathways differ substantially in their underlying molecular mechanisms, implying that the risk factor profiles for the two types of lesions may be different. However, existing evidence remains fragmented, and an integrated comparative synthesis of these differential associations is lacking. In this review, we synthesize and compare current evidence on the mechanistic characteristics and lifestyle, metabolic, and nutritional determinants of conventional adenomas and serrated lesions. By synthesizing the available evidence on the two precursor pathways, this review may contribute to a better understanding of conventional adenomas and serrated lesions, and offer insights for future research into their distinct risk factors, underlying mechanisms, and implications for colorectal cancer prevention.
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BibTeX
@article{cai2026differential,
title = {{Differential risk and protective factors for conventional adenomas and serrated lesions: implications for colorectal cancer prevention}},
author = {Junjie Cai and Yiliu Huang and Yi Luo and Hui Zeng and Jun Yang and Yingshuang Zhu},
journal = {Frontiers in Public Health},
year = {2026},
month = oct,
doi = {10.3389/fpubh.2026.1949376},
url = {https://www.frontiersin.org/articles/10.3389/fpubh.2026.1949376/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Differential risk and protective factors for conventional adenomas and serrated lesions: implications for colorectal cancer prevention
AU - Junjie Cai
AU - Yiliu Huang
AU - Yi Luo
AU - Hui Zeng
AU - Jun Yang
AU - Yingshuang Zhu
PY - 2026
DA - 2026/10/14
JO - Frontiers in Public Health
DO - 10.3389/fpubh.2026.1949376
UR - https://www.frontiersin.org/articles/10.3389/fpubh.2026.1949376/full
AB - Conventional adenomas and serrated lesions are two major precursor lesions of colorectal cancer. They arise through distinct carcinogenic pathways, namely the conventional adenoma–carcinoma sequence and the serrated neoplasia pathway. These pathways differ substantially in their underlying molecular mechanisms, implying that the risk factor profiles for the two types of lesions may be different. However, existing evidence remains fragmented, and an integrated comparative synthesis of these differential associations is lacking. In this review, we synthesize and compare current evidence on the mechanistic characteristics and lifestyle, metabolic, and nutritional determinants of conventional adenomas and serrated lesions. By synthesizing the available evidence on the two precursor pathways, this review may contribute to a better understanding of conventional adenomas and serrated lesions, and offer insights for future research into their distinct risk factors, underlying mechanisms, and implications for colorectal cancer prevention.
SN - 2296-2565
ER -