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Peer-reviewedCC BYInternational journal of molecular sciences

Biological Activity of 3-Hydroxypyridine Derivatives with Natural Components

  • Irina V. Zhigacheva1
  • Elena M. Mil1
  • Irina F. Rusina2
  • Natalya I. Krikunova1
  • Ludmila I. Matienko1
  • Timur L. Veprintsev1
  • Anastasia A. Albantova1
  • Alexander N. Goloshchapov1
  1. 1Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, St. Kosygin, 4, Moscow 119334, Russia
  2. 2N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, St. Kosygin, 4, Moscow 119334, Russia
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Abstract

We investigated the antiradical properties of antioxidants: carnitinate 2-ethyl-6-methyl-3-hydroxypyridine (CAR-3-HP) and carboxychromate-2-ethyl-6-methyl-3-hydroxypyridine (CCR-3-HP), and also assessed the mitochondrial response to stress (hypoxia) by analyzing the intensity of lipid peroxidation, membrane fatty acid composition, and activation of autophagy markers LC3 and Beclin-1 using spectrofluorimetry, chromatography, and immunoblotting, respectively. The studied antioxidants exhibited high antiradical activity, which was reflected in their ability to inhibit lipid peroxidation. Five-day administration of antioxidants to mice at a dose of 2 × 10−9 mol/kg prevented the activation of lipid peroxidation in liver mitochondrial membranes under conditions of acute hypobaric hypoxia. The drugs also prevented a decrease in C18 and C20 fatty acid levels, and also activated autophagy. In both cases, CAR-3-HP was more effective than CCR-3-HP. This drug increased the lifespan of mice almost twice as effectively under conditions of various types of hypoxias.

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Cite

BibTeXRIS
BibTeX
@article{zhigacheva2026biological,
  title = {{Biological Activity of 3-Hydroxypyridine Derivatives with Natural Components}},
  author = {Irina V. Zhigacheva and Elena M. Mil and Irina F. Rusina and Natalya I. Krikunova and Ludmila I. Matienko and Timur L. Veprintsev and Anastasia A. Albantova and Alexander N. Goloshchapov},
  journal = {International journal of molecular sciences},
  year = {2026},
  month = oct,
  doi = {10.3390/ijms27198903},
  url = {https://europepmc.org/article/PMC/PMC13665236},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Biological Activity of 3-Hydroxypyridine Derivatives with Natural Components
AU  - Irina V. Zhigacheva
AU  - Elena M. Mil
AU  - Irina F. Rusina
AU  - Natalya I. Krikunova
AU  - Ludmila I. Matienko
AU  - Timur L. Veprintsev
AU  - Anastasia A. Albantova
AU  - Alexander N. Goloshchapov
PY  - 2026
DA  - 2026/10/01
JO  - International journal of molecular sciences
DO  - 10.3390/ijms27198903
UR  - https://europepmc.org/article/PMC/PMC13665236
AB  - We investigated the antiradical properties of antioxidants: carnitinate 2-ethyl-6-methyl-3-hydroxypyridine (CAR-3-HP) and carboxychromate-2-ethyl-6-methyl-3-hydroxypyridine (CCR-3-HP), and also assessed the mitochondrial response to stress (hypoxia) by analyzing the intensity of lipid peroxidation, membrane fatty acid composition, and activation of autophagy markers LC3 and Beclin-1 using spectrofluorimetry, chromatography, and immunoblotting, respectively. The studied antioxidants exhibited high antiradical activity, which was reflected in their ability to inhibit lipid peroxidation. Five-day administration of antioxidants to mice at a dose of 2 × 10−9 mol/kg prevented the activation of lipid peroxidation in liver mitochondrial membranes under conditions of acute hypobaric hypoxia. The drugs also prevented a decrease in C18 and C20 fatty acid levels, and also activated autophagy. In both cases, CAR-3-HP was more effective than CCR-3-HP. This drug increased the lifespan of mice almost twice as effectively under conditions of various types of hypoxias.
SN  - 1422-0067
ER  -