Diagnostic capability of perimetry and optical coherence tomography based retinal thickness measurements in diabetic patients with no or mild retinopathy
4 affiliations
- 1Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Optometry, School of Paramedical Sciences and Rehabilitation, Mashhad University of Medical Sciences, Mashhad, Iran
- 2Department of Optometry, School of Paramedical Sciences and Rehabilitation, Mashhad University of Medical Sciences, Mashhad, Iran
- 3Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Optometry, School of Paramedical Sciences and Rehabilitation, Mashhad University of Medical Sciences, Mashhad, Iran; Corresponding author at: Department of Optometry, School of Paramedical Sciences and Rehabilitation, Mashhad University of Medical Sciences, Mashhad, Iran.
- 4Department of Ophthalmology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
Abstract
Purpose: This study aimed to compare and evaluate the diagnostic potential of visual field parameters and different retinal layers thicknesses among diabetic patients with and without diabetic retinopathy and non-diabetic controls. Methods: A total of 174 participants were enrolled and divided equally into three groups of 58 subjects: (1) healthy controls, (2) diabetic patients without diabetic retinopathy (NoDR), and (3) diabetic patients with mild non-proliferative diabetic retinopathy (NPDR). Retinal layer thicknesses (eight layers × five macular sectors) and visual field (mean deviation, MD; pattern standard deviation, PSD) were compared using one-way ANOVA with Tukey post-hoc testing. Pearson correlations between MD/PSD and retinal layer thickness were computed to test structure–function association. Results: Temporal NFL thickness was markedly greater in NPDR (25.14 ± 8.62 µm) than in NoDR (19.43 ± 4.17 µm) or controls (19.34 ± 5.15 µm; P < 0.001), and this difference persisted after age adjustment (P < 0.001). MD showed good diagnostic performance for NoDR vs control (AUC 0.766) and NPDR vs control (AUC 0.876), outperforming PSD (AUC 0.646 and 0.719, respectively); the NoDR-vs-control MD difference remained significant after age adjustment (P = 0.011) but was substantially attenuated, and the PSD group difference was fully explained by age (age-adjusted P = 0.80). No meaningful correlation was found between MD/PSD and any retinal layer thickness (all |r| < 0.21). Conclusion: Temporal NFL thickening in NPDR and reduced visual field MD represent the most robust structural and functional abnormalities in this study.
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BibTeX
@article{sharif2026diagnostic,
title = {{Diagnostic capability of perimetry and optical coherence tomography based retinal thickness measurements in diabetic patients with no or mild retinopathy}},
author = {Nasrin Moghadas Sharif and Faezeh Noferesti and Maliheh Karimpour and Ata Asiaei},
journal = {Photodiagnosis and Photodynamic Therapy},
year = {2026},
month = oct,
doi = {10.1016/j.pdpdt.2026.105692},
url = {https://doi.org/10.1016/j.pdpdt.2026.105692},
note = {CC BY},
}
RIS
TY - JOUR
TI - Diagnostic capability of perimetry and optical coherence tomography based retinal thickness measurements in diabetic patients with no or mild retinopathy
AU - Nasrin Moghadas Sharif
AU - Faezeh Noferesti
AU - Maliheh Karimpour
AU - Ata Asiaei
PY - 2026
DA - 2026/10/30
JO - Photodiagnosis and Photodynamic Therapy
DO - 10.1016/j.pdpdt.2026.105692
UR - https://doi.org/10.1016/j.pdpdt.2026.105692
AB - Purpose: This study aimed to compare and evaluate the diagnostic potential of visual field parameters and different retinal layers thicknesses among diabetic patients with and without diabetic retinopathy and non-diabetic controls. Methods: A total of 174 participants were enrolled and divided equally into three groups of 58 subjects: (1) healthy controls, (2) diabetic patients without diabetic retinopathy (NoDR), and (3) diabetic patients with mild non-proliferative diabetic retinopathy (NPDR). Retinal layer thicknesses (eight layers × five macular sectors) and visual field (mean deviation, MD; pattern standard deviation, PSD) were compared using one-way ANOVA with Tukey post-hoc testing. Pearson correlations between MD/PSD and retinal layer thickness were computed to test structure–function association. Results: Temporal NFL thickness was markedly greater in NPDR (25.14 ± 8.62 µm) than in NoDR (19.43 ± 4.17 µm) or controls (19.34 ± 5.15 µm; P < 0.001), and this difference persisted after age adjustment (P < 0.001). MD showed good diagnostic performance for NoDR vs control (AUC 0.766) and NPDR vs control (AUC 0.876), outperforming PSD (AUC 0.646 and 0.719, respectively); the NoDR-vs-control MD difference remained significant after age adjustment (P = 0.011) but was substantially attenuated, and the PSD group difference was fully explained by age (age-adjusted P = 0.80). No meaningful correlation was found between MD/PSD and any retinal layer thickness (all |r| < 0.21). Conclusion: Temporal NFL thickening in NPDR and reduced visual field MD represent the most robust structural and functional abnormalities in this study.
SN - 1572-1000
SN - 1873-1597
ER -