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Peer-reviewedCC BYDiagnostics (Basel, Switzerland)

Association of the ApoB/ApoA1 Ratio with Angiographically Documented Coronary Artery Disease: Comparison with Conventional Lipid Markers.

  • Tiberiu-Liviu Dragomir1,2
  • Horia Silviu Branea1,2,3
  • Minodora Andor1,2,3
  • Ioana Mihaela Cîtu2,3,4
  • Florina Rozina Căruntu1,2,3
  • Monica Maria Șușan4
  • Cristina Marinela Oprean5,6
  • Raul-Tiberiu Dragomir7
  • Răzvan Mihai Șușan8
  • Delia Huțanu9
  • Dan Dumitru Vulcanescu10,11,12
  • Adriana Daniela Dragomir13
13 affiliations
  1. 1Medical Semiology II Discipline, Department V-Internal Medicine I, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
  2. 2Multidisciplinary Heart Research Center, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
  3. 3Cardiology Clinic-ASCAR, Timișoara Municipal Emergency Clinical Hospital, Bd. Revoluției din 1989 No. 12, 300041 Timișoara, Romania.
  4. 4Medical Semiology I Discipline, Department V-Internal Medicine I, Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
  5. 5ANAPATMOL Research Center, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
  6. 6Department of Oncology, ONCOHELP Hospital, Ciprian Porumbescu Street No. 59, 300239 Timișoara, Romania.
  7. 7Faculty of Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
  8. 8Department of Family Medicine, Centre for Preventive Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
  9. 9Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timișoara, Johann Heinrich Pestalozzi Street No. 16A, 300115 Timișoara, Romania.
  10. 10Department of Microbiology, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
  11. 11Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Department of Microbiology, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.
  12. 12Clinical Laboratory, "Louis Țurcanu" Emergency Clinical Hospital for Children, Iosif Nemoianu Street No. 2, 300011 Timișoara, Romania.
  13. 13Department of Allergology, Giroc Medical Center, Str. Trandafirilor No. 7, 307220 Timiș, Romania.
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Abstract

Background/Objectives: The apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio has been proposed as an integrated marker of atherogenic and anti-atherogenic lipoprotein balance. This study assessed its association with the presence and angiographic severity of coronary artery disease (CAD) and compared its discriminatory performance with conventional lipid markers. Methods: This retrospective, observational, cross-sectional study included 63 adults undergoing coronary angiography for suspected or established CAD. Pre-procedural ApoB, ApoA1, and conventional lipid parameters were measured. Significant CAD was defined as ≥50% stenosis in at least one major epicardial coronary artery. Associations with angiographic severity were assessed using Gensini and SYNTAX scores. Statistical analyses included between-group comparisons, Spearman correlations, ROC analysis with DeLong comparisons, and logistic regression. Results: Significant CAD was present in 46 patients (73.02%). ApoB and ApoB/ApoA1 were higher in patients with significant CAD (p = 0.011 and p = 0.013), whereas ApoA1 was not (p = 0.101). ApoB/ApoA1 correlated weakly with Gensini score (ρ = 0.30, p = 0.046), but not with SYNTAX Scores I or II. In the complete-case subset (n = 55), ApoB/ApoA1 had an AUC of 0.68, with no significant differences versus LDL-C, HDL-C, total cholesterol, or triglycerides. Each 0.1-unit increase in ApoB/ApoA1 was associated with higher odds of significant CAD after adjustment for age, diabetes mellitus, and smoking (adjusted OR 1.63, 95% CI 1.08-2.48; p = 0.021). Conclusions: ApoB/ApoA1 was associated with significant CAD after adjustment for selected clinical variables, but this association was attenuated after additional adjustment for LDL-C. Its discriminatory performance was modest and not significantly different from conventional lipid markers, requiring further evaluation as a potential pre-angiographic risk marker.

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Cite

BibTeXRIS
BibTeX
@article{dragomir2026association,
  title = {{Association of the ApoB/ApoA1 Ratio with Angiographically Documented Coronary Artery Disease: Comparison with Conventional Lipid Markers.}},
  author = {Tiberiu-Liviu Dragomir and Horia Silviu Branea and Minodora Andor and Ioana Mihaela Cîtu and Florina Rozina Căruntu and Monica Maria Șușan and Cristina Marinela Oprean and Raul-Tiberiu Dragomir and Răzvan Mihai Șușan and Delia Huțanu and Dan Dumitru Vulcanescu and Adriana Daniela Dragomir},
  journal = {Diagnostics (Basel, Switzerland)},
  year = {2026},
  month = oct,
  doi = {10.3390/diagnostics16193245},
  url = {https://europepmc.org/article/MED/42882400},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Association of the ApoB/ApoA1 Ratio with Angiographically Documented Coronary Artery Disease: Comparison with Conventional Lipid Markers.
AU  - Tiberiu-Liviu Dragomir
AU  - Horia Silviu Branea
AU  - Minodora Andor
AU  - Ioana Mihaela Cîtu
AU  - Florina Rozina Căruntu
AU  - Monica Maria Șușan
AU  - Cristina Marinela Oprean
AU  - Raul-Tiberiu Dragomir
AU  - Răzvan Mihai Șușan
AU  - Delia Huțanu
AU  - Dan Dumitru Vulcanescu
AU  - Adriana Daniela Dragomir
PY  - 2026
DA  - 2026/10/08
JO  - Diagnostics (Basel, Switzerland)
DO  - 10.3390/diagnostics16193245
UR  - https://europepmc.org/article/MED/42882400
AB  - Background/Objectives: The apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio has been proposed as an integrated marker of atherogenic and anti-atherogenic lipoprotein balance. This study assessed its association with the presence and angiographic severity of coronary artery disease (CAD) and compared its discriminatory performance with conventional lipid markers. Methods: This retrospective, observational, cross-sectional study included 63 adults undergoing coronary angiography for suspected or established CAD. Pre-procedural ApoB, ApoA1, and conventional lipid parameters were measured. Significant CAD was defined as ≥50% stenosis in at least one major epicardial coronary artery. Associations with angiographic severity were assessed using Gensini and SYNTAX scores. Statistical analyses included between-group comparisons, Spearman correlations, ROC analysis with DeLong comparisons, and logistic regression. Results: Significant CAD was present in 46 patients (73.02%). ApoB and ApoB/ApoA1 were higher in patients with significant CAD (p = 0.011 and p = 0.013), whereas ApoA1 was not (p = 0.101). ApoB/ApoA1 correlated weakly with Gensini score (ρ = 0.30, p = 0.046), but not with SYNTAX Scores I or II. In the complete-case subset (n = 55), ApoB/ApoA1 had an AUC of 0.68, with no significant differences versus LDL-C, HDL-C, total cholesterol, or triglycerides. Each 0.1-unit increase in ApoB/ApoA1 was associated with higher odds of significant CAD after adjustment for age, diabetes mellitus, and smoking (adjusted OR 1.63, 95% CI 1.08-2.48; p = 0.021). Conclusions: ApoB/ApoA1 was associated with significant CAD after adjustment for selected clinical variables, but this association was attenuated after additional adjustment for LDL-C. Its discriminatory performance was modest and not significantly different from conventional lipid markers, requiring further evaluation as a potential pre-angiographic risk marker.
SN  - 2075-4418
ER  -