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Peer-reviewedCC BYChemistry & biodiversity

Lipid-Polymeric Nanoencapsulation of Standardized Camellia sinensis Extract Enhances Antiangiogenic Activity and Ocular Biocompatibility.

  • Sarah Kelly Fernandes1
  • Anízio Bastos de Souza1
  • Líbia Andressa Leandro de Paula1
  • Alessandra Cristine de Souza Matavel2
  • Marcos Paulo Gomes Mol3
  • Mariana de Oliveira Almeida4
  • Vanessa Heloísa Ferreira de Faria4
  • Carolina Paula de Souza Moreira1
4 affiliations
  1. 1Serviço De Desenvolvimento Tecnológico Farmacêutico, Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.
  2. 2Serviço De Toxinologia Molecular, Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.
  3. 3Serviço De Ecotoxinologia, Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.
  4. 4Serviço Química Especializada, Diretoria Do Instituto Octávio Magalhães, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.
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Abstract

Camellia sinensis (green tea) contains bioactive polyphenols with potential antiangiogenic activity; however, its therapeutic application is limited by extract complexity and challenges related to delivery. This study developed a lipid-polymeric nanoparticle system containing a chemically standardized C. sinensis extract and evaluated its physicochemical properties, biocompatibility, and antiangiogenic activity. The optimized nanoformulation exhibited a mean diameter of 202.0 ± 5.2 nm, polydispersity index (PDI) of 0.156 ± 0.017, and zeta potential of -25.1 ± 0.6 mV, with an encapsulation efficiency of approximately 34.6 ± 1.5%. The formulation maintained suitable physicochemical characteristics during storage and showed no relevant irritation in the HET-CAM assay. In the chick chorioallantoic membrane (CAM) assay, extract-loaded nanoparticles reduced vascularization, displaying an antiangiogenic effect comparable to bevacizumab. These findings support lipid-polymeric nanoencapsulation as a promising strategy to improve the biological performance of complex plant-derived extracts for ocular angiogenic disorders.

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Cite

BibTeXRIS
BibTeX
@article{fernandes2026lipidpolymeric,
  title = {{Lipid-Polymeric Nanoencapsulation of Standardized Camellia sinensis Extract Enhances Antiangiogenic Activity and Ocular Biocompatibility.}},
  author = {Sarah Kelly Fernandes and Anízio Bastos de Souza and Líbia Andressa Leandro de Paula and Alessandra Cristine de Souza Matavel and Marcos Paulo Gomes Mol and Mariana de Oliveira Almeida and Vanessa Heloísa Ferreira de Faria and Carolina Paula de Souza Moreira},
  journal = {Chemistry \& biodiversity},
  year = {2026},
  month = nov,
  doi = {10.1002/cbdv.71893},
  url = {https://europepmc.org/article/MED/42967485},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Lipid-Polymeric Nanoencapsulation of Standardized Camellia sinensis Extract Enhances Antiangiogenic Activity and Ocular Biocompatibility.
AU  - Sarah Kelly Fernandes
AU  - Anízio Bastos de Souza
AU  - Líbia Andressa Leandro de Paula
AU  - Alessandra Cristine de Souza Matavel
AU  - Marcos Paulo Gomes Mol
AU  - Mariana de Oliveira Almeida
AU  - Vanessa Heloísa Ferreira de Faria
AU  - Carolina Paula de Souza Moreira
PY  - 2026
DA  - 2026/11/01
JO  - Chemistry & biodiversity
DO  - 10.1002/cbdv.71893
UR  - https://europepmc.org/article/MED/42967485
AB  - Camellia sinensis (green tea) contains bioactive polyphenols with potential antiangiogenic activity; however, its therapeutic application is limited by extract complexity and challenges related to delivery. This study developed a lipid-polymeric nanoparticle system containing a chemically standardized C. sinensis extract and evaluated its physicochemical properties, biocompatibility, and antiangiogenic activity. The optimized nanoformulation exhibited a mean diameter of 202.0 ± 5.2 nm, polydispersity index (PDI) of 0.156 ± 0.017, and zeta potential of -25.1 ± 0.6 mV, with an encapsulation efficiency of approximately 34.6 ± 1.5%. The formulation maintained suitable physicochemical characteristics during storage and showed no relevant irritation in the HET-CAM assay. In the chick chorioallantoic membrane (CAM) assay, extract-loaded nanoparticles reduced vascularization, displaying an antiangiogenic effect comparable to bevacizumab. These findings support lipid-polymeric nanoencapsulation as a promising strategy to improve the biological performance of complex plant-derived extracts for ocular angiogenic disorders.
SN  - 1612-1872
SN  - 1612-1880
ER  -