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Peer-reviewedCC BY-NC-NDInternal Medicine

Coexistence of Clonally Unrelated Acute Myeloid Leukemia Harboring CBFB::MYH11 and Lymphoplasmacytic Lymphoma Harboring MYD88 L252P Mutation

  • Kodama Shimanaka
  • Tatsuhiro Sakamoto
  • Kenichi Makishima
  • Fumiaki Matsumura
  • Sakurako Suma
  • Yuya Sasaki
  • Yasuhito Suehara
  • Takayasu Kato
  • Keiichiro Hattori
  • Naoki Kurita
  • Hidekazu Nishikii
  • Naoshi Obara
1 more authors
  • Mamiko Sakata-Yanagimoto
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Abstract

We herein report a rare case of non-IgM lymphoplasmacytic lymphoma (LPL) and acute myeloid leukemia (AML). A 64-year-old man with MYD88 L252P-positive LPL developed inv(16)-positive AML during LPL follow-up. Chemotherapy eradicated both AML and LPL cells from the bone marrow. Whole-exome sequencing revealed distinct mutation profiles with no shared mutations between the LPL and AML clones. These data suggest the coincidental development of genetically independent clones rather than a common ancestral origin. Our findings indicate the need for genomic stratification in dual hematological malignancies to accurately distinguish between coincidental and clonally related diseases.

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Cite

BibTeXRIS
BibTeX
@article{shimanaka2026coexistence,
  title = {{Coexistence of Clonally Unrelated Acute Myeloid Leukemia Harboring CBFB::MYH11 and Lymphoplasmacytic Lymphoma Harboring MYD88 L252P Mutation}},
  author = {Kodama Shimanaka and Tatsuhiro Sakamoto and Kenichi Makishima and Fumiaki Matsumura and Sakurako Suma and Yuya Sasaki and Yasuhito Suehara and Takayasu Kato and Keiichiro Hattori and Naoki Kurita and Hidekazu Nishikii and Naoshi Obara and Mamiko Sakata-Yanagimoto},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.7759-26},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7759-26/_article},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Coexistence of Clonally Unrelated Acute Myeloid Leukemia Harboring CBFB::MYH11 and Lymphoplasmacytic Lymphoma Harboring MYD88 L252P Mutation
AU  - Kodama Shimanaka
AU  - Tatsuhiro Sakamoto
AU  - Kenichi Makishima
AU  - Fumiaki Matsumura
AU  - Sakurako Suma
AU  - Yuya Sasaki
AU  - Yasuhito Suehara
AU  - Takayasu Kato
AU  - Keiichiro Hattori
AU  - Naoki Kurita
AU  - Hidekazu Nishikii
AU  - Naoshi Obara
AU  - Mamiko Sakata-Yanagimoto
PY  - 2026
DA  - 2026/09/29
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7759-26
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7759-26/_article
AB  - We herein report a rare case of non-IgM lymphoplasmacytic lymphoma (LPL) and acute myeloid leukemia (AML). A 64-year-old man with MYD88 L252P-positive LPL developed inv(16)-positive AML during LPL follow-up. Chemotherapy eradicated both AML and LPL cells from the bone marrow. Whole-exome sequencing revealed distinct mutation profiles with no shared mutations between the LPL and AML clones. These data suggest the coincidental development of genetically independent clones rather than a common ancestral origin. Our findings indicate the need for genomic stratification in dual hematological malignancies to accurately distinguish between coincidental and clonally related diseases.
SN  - 1349-7235
SN  - 0918-2918
ER  -