Severe Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia
Abstract
A 79-year-old female presented with progressive dyspnea. A bone marrow biopsy revealed hypoplastic marrow with abnormal lymphoid cells. A genetic analysis revealed a MYD88 p.V204F mutation, supporting the diagnosis of lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM). Additional evaluations established a concomitant diagnosis of aplastic anemia (AA). Treatment prioritized AA with cyclosporine and eltrombopag. Subsequently, the LPL/WM was treated with rituximab monotherapy. This sequential treatment resulted in a symptomatic improvement. Although AA is a diagnosis of exclusion, its coexistence with lymphoma is rare. This case highlights the diagnostic and therapeutic complexity of AA and LPL/WM overlap and suggests that prioritizing the treatment of AA may lead to better outcomes.
Related
- The Challenges Associated with the Diagnosis and Treatment for Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia
- Real-World Treatment Patterns, Healthcare Resource Use, and Costs in Patients with Follicular Lymphoma, Waldenström Macroglobulinemia, and Marginal Zone Lymphoma: A Claims-Based Study in the USA
- Relapsed Waldenström macroglobulinemia presenting as bilateral parotid gland enlargement with multiple cystic lesions : A case report
- Waldenström macroglobulinemia presenting with lumbar vertebral fracture as the initial symptom: a rare case report and literature review
- UMA RARA ASSOCIAÇÃO ENTRE MACROGLOBULINEMIA DE WALDENSTRÖM E LINFOMA DE HODGKIN CLÁSSICO: RELATO DE CASO
BibTeX
@article{okuda2026severe,
title = {{Severe Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia}},
author = {Takehiro Okuda and Yuta Hanyu and Hana Mineshige and Yuta Inoue and Maki Sakurada and Masashi Matsui and Naomi Katsuki and Makoto Iwasaki and June Takeda and Junya Kanda and Yasuhito Nannya and Seishi Ogawa and Akifumi Takaori-Kondo and Yasuko Miyahara and Mitsuru Itoh},
journal = {Internal Medicine},
year = {2026},
month = oct,
doi = {10.2169/internalmedicine.6790-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6790-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Severe Aplastic Anemia Concurrent with Lymphoplasmacytic Lymphoma/Waldenström's Macroglobulinemia
AU - Takehiro Okuda
AU - Yuta Hanyu
AU - Hana Mineshige
AU - Yuta Inoue
AU - Maki Sakurada
AU - Masashi Matsui
AU - Naomi Katsuki
AU - Makoto Iwasaki
AU - June Takeda
AU - Junya Kanda
AU - Yasuhito Nannya
AU - Seishi Ogawa
AU - Akifumi Takaori-Kondo
AU - Yasuko Miyahara
AU - Mitsuru Itoh
PY - 2026
DA - 2026/10/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.6790-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6790-25/_article
AB - A 79-year-old female presented with progressive dyspnea. A bone marrow biopsy revealed hypoplastic marrow with abnormal lymphoid cells. A genetic analysis revealed a MYD88 p.V204F mutation, supporting the diagnosis of lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia (LPL/WM). Additional evaluations established a concomitant diagnosis of aplastic anemia (AA). Treatment prioritized AA with cyclosporine and eltrombopag. Subsequently, the LPL/WM was treated with rituximab monotherapy. This sequential treatment resulted in a symptomatic improvement. Although AA is a diagnosis of exclusion, its coexistence with lymphoma is rare. This case highlights the diagnostic and therapeutic complexity of AA and LPL/WM overlap and suggests that prioritizing the treatment of AA may lead to better outcomes.
SN - 1349-7235
SN - 0918-2918
ER -