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Peer-reviewedCC BYJournal of rehabilitation medicine

Long-term effects of spinal cord stimulation combined with a physiotherapist-led exercise programme and physical activity on prescription for chronic neuropathic pain.

  • Raquel Gottfridsson1
  • Emma Varkey2
  • Kliment Gatzinsky3
  • Helena Thörn4
  • Mats Börjesson5
  • Daniel Arvidsson6
  • Sven-Egron Thörn7
  • Axel Wolf
  • Paulin Andréll7
7 affiliations
  1. 1Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, Sahlgrenska University Hospital/Östra, Gothenburg, Region Västra Götaland, Sweden; Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. [email protected].
  2. 2Department of Occupational Therapy and Physical Therapy, Sahlgrenska University Hospital/Östra, Gothenburg, Region Västra Götaland, Sweden; Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  3. 3Department of Neurosurgery, Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  4. 4Department of Oncology and Palliative Medicine, Halland Regional Hospital, Varberg, Sweden.
  5. 5Department of Medicine, Geriatrics and Emergency Care, Centre for Lifestyle Intervention, Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  6. 6Department of Medicine, Geriatrics and Emergency Care, Centre for Lifestyle Intervention, Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden; Department of Food and Nutrition and Sport Science, Faculty of Education, University of Gothenburg, Gothenburg, Sweden.
  7. 7Department of Anaesthesiology, Intensive Care Medicine and Pain Medicine, Sahlgrenska University Hospital/Östra, Gothenburg, Region Västra Götaland, Sweden; Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
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Abstract

Objective

Assess the effects of spinal cord stimulation and add-on physical activity interventions on pain, physical activity levels, and health-related quality of life.Design

Prospective single-arm.Subjects/patients

35 adults who underwent spinal cord stimulation device implantation for neuropathic pain completed the study.Methods

Three months after implantation, participants initiated a 6-month individualized physiotherapist-led exercise programme, followed by 12 months of physical activity on prescription. Neuropathic pain intensity (Numeric Rating Scale, 0-10), physical activity (accelerometer), and health-related quality of life (EuroQol 5-dimensions, visual analogue scale, EQ-5D VAS; 0-100) were assessed at baseline and 3, 9, and 21 months after implantation.Results

Neuropathic pain was reduced from baseline at 9 and 21 months (mean [SD] = 6.6 [1.7] at baseline; 4.8 [2.3] at 9 months, p = 0.003; 4.8 [2.1] at 21 months, p = 0.003). EQ-5D VAS scores increased significantly by 16 (p = 0.027) and 15 (p = 0.003) points at 9 and 21 months, respectively. No changes in physical activity were observed. Changes from 3 months were not statistically significant at 9 or 21 months for any outcomes.Conclusion

The initial effects of spinal cord stimulation on pain and health-related quality of life remained after the introduction of physical activity interventions, with no additional improvements observed beyond 3 months after implantation.

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Cite

BibTeXRIS
BibTeX
@article{gottfridsson2026longterm,
  title = {{Long-term effects of spinal cord stimulation combined with a physiotherapist-led exercise programme and physical activity on prescription for chronic neuropathic pain.}},
  author = {Raquel Gottfridsson and Emma Varkey and Kliment Gatzinsky and Helena Thörn and Mats Börjesson and Daniel Arvidsson and Sven-Egron Thörn and Axel Wolf and Paulin Andréll},
  journal = {Journal of rehabilitation medicine},
  year = {2026},
  month = oct,
  doi = {10.2340/jrm.v58.46459},
  url = {https://europepmc.org/article/MED/42870412},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Long-term effects of spinal cord stimulation combined with a physiotherapist-led exercise programme and physical activity on prescription for chronic neuropathic pain.
AU  - Raquel Gottfridsson
AU  - Emma Varkey
AU  - Kliment Gatzinsky
AU  - Helena Thörn
AU  - Mats Börjesson
AU  - Daniel Arvidsson
AU  - Sven-Egron Thörn
AU  - Axel Wolf
AU  - Paulin Andréll
PY  - 2026
DA  - 2026/10/14
JO  - Journal of rehabilitation medicine
DO  - 10.2340/jrm.v58.46459
UR  - https://europepmc.org/article/MED/42870412
AB  - Objective  Assess the effects of spinal cord stimulation and add-on physical activity interventions on pain, physical activity levels, and health-related quality of life.Design  Prospective single-arm.Subjects/patients  35 adults who underwent spinal cord stimulation device implantation for neuropathic pain completed the study.Methods  Three months after implantation, participants initiated a 6-month individualized physiotherapist-led exercise programme, followed by 12 months of physical activity on prescription. Neuropathic pain intensity (Numeric Rating Scale, 0-10), physical activity (accelerometer), and health-related quality of life (EuroQol 5-dimensions, visual analogue scale, EQ-5D VAS; 0-100) were assessed at baseline and 3, 9, and 21 months after implantation.Results  Neuropathic pain was reduced from baseline at 9 and 21 months (mean [SD] = 6.6 [1.7] at baseline; 4.8 [2.3] at 9 months, p = 0.003; 4.8 [2.1] at 21 months, p = 0.003). EQ-5D VAS scores increased significantly by 16 (p = 0.027) and 15 (p = 0.003) points at 9 and 21 months, respectively. No changes in physical activity were observed. Changes from 3 months were not statistically significant at 9 or 21 months for any outcomes.Conclusion  The initial effects of spinal cord stimulation on pain and health-related quality of life remained after the introduction of physical activity interventions, with no additional improvements observed beyond 3 months after implantation.
SN  - 1650-1977
SN  - 1651-2081
ER  -