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Peer-reviewedCC BY-NC-NDClinical and translational radiation oncology

Efficacy and safety of single-fraction stereotactic body radiotherapy (SBRT) for the curative treatment of extracranial primary Tumors: A collaborative systematic review on behalf of the SBRT Focus Group of the European Society for Radiotherapy & Oncology (ESTRO).

  • Francesco Cuccia1
  • Ciro Franzese2,3
  • Suraiya Dubash4,5
  • Valeria Dionisi6
  • Thomas Brunner7
  • Francesco Cellini8,9
  • Juliane Hörner-Rieber10
  • Thomas Zilli11,12,13,14
  • Bartłomiej Tomasik15,16
  • Dirk Verellen17,18
  • Stephanie Tanadini-Lang19
  • Marta Scorsetti2,3
19 affiliations
  1. 1Radiation Oncology, ARNAS Civico Hospital, Palermo, Italy.
  2. 2Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  3. 3Department of Radiotherapy and Radiosurgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.
  4. 4Department of Oncology, Mount Vernon Cancer Centre, Northwood, United Kingdom.
  5. 5Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
  6. 6Department of Medical Oncology, University and Hospital Trust, Verona, Italy.
  7. 7Department of Radiation Oncology, Medical University of Graz, Graz, Austria.
  8. 8Department of Radiation Oncology, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome, Rome, Italy.
  9. 9Università; Cattolica del Sacro Cuore, Dipartimento Universitario Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Rome, Italy.
  10. 10Department of Radiation Oncology, Düsseldorf University Hospital, Düsseldorf, Germany.
  11. 11Radiation Oncology, Oncology Institute of Southern Switzerland; Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  12. 12Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
  13. 13Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  14. 14Faculty of Biomedical Sciences, Università Della Svizzera Italiana, Lugano, Switzerland.
  15. 15Department of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
  16. 16Centre for Experimental CardioOncology, Medical University of Gdańsk, Gdańsk, Poland.
  17. 17Department of Radiation Oncology, Iridium Network, Wilrijk, (Antwerp), Belgium.
  18. 18Integrated Personalised and Precision Oncology Network, University Antwerp, Antwerp, Belgium.
  19. 19Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
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Abstract

Single-fraction stereotactic body radiotherapy (SF-SBRT) represents one of the most advanced frontiers in modern radiation oncology. While ultra-hypofractionation has entered everyday clinical practice in different fields of the oncological care, curative treatments in one session are increasingly attractive for the potential favorable combination of logistic advantages with safety and clinical outcomes. This collaborative systematic review promoted by the ESTRO SBRT Focus Group in participation with members of different disease-site Focus Groups collects the available data in support of SF-SBRT for the curative treatment of the main extracranial primary tumors. The findings highlight that, for specific anatomical sites, SF-SBRT is both safe and effective though the results emphasize the critical importance of careful patient selection and mandatory technological requirements for treatment planning and delivery. This collaborative work provides a comprehensive overview of current evidence and identifies key knowledge gaps for future investigation and upcoming clinical trials.

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Cite

BibTeXRIS
BibTeX
@article{cuccia2026efficacy,
  title = {{Efficacy and safety of single-fraction stereotactic body radiotherapy (SBRT) for the curative treatment of extracranial primary Tumors: A collaborative systematic review on behalf of the SBRT Focus Group of the European Society for Radiotherapy & Oncology (ESTRO).}},
  author = {Francesco Cuccia and Ciro Franzese and Suraiya Dubash and Valeria Dionisi and Thomas Brunner and Francesco Cellini and Juliane Hörner-Rieber and Thomas Zilli and Bartłomiej Tomasik and Dirk Verellen and Stephanie Tanadini-Lang and Marta Scorsetti},
  journal = {Clinical and translational radiation oncology},
  year = {2026},
  month = oct,
  doi = {10.1016/j.ctro.2026.101295},
  url = {https://europepmc.org/article/MED/42898625},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Efficacy and safety of single-fraction stereotactic body radiotherapy (SBRT) for the curative treatment of extracranial primary Tumors: A collaborative systematic review on behalf of the SBRT Focus Group of the European Society for Radiotherapy & Oncology (ESTRO).
AU  - Francesco Cuccia
AU  - Ciro Franzese
AU  - Suraiya Dubash
AU  - Valeria Dionisi
AU  - Thomas Brunner
AU  - Francesco Cellini
AU  - Juliane Hörner-Rieber
AU  - Thomas Zilli
AU  - Bartłomiej Tomasik
AU  - Dirk Verellen
AU  - Stephanie Tanadini-Lang
AU  - Marta Scorsetti
PY  - 2026
DA  - 2026/10/01
JO  - Clinical and translational radiation oncology
DO  - 10.1016/j.ctro.2026.101295
UR  - https://europepmc.org/article/MED/42898625
AB  - Single-fraction stereotactic body radiotherapy (SF-SBRT) represents one of the most advanced frontiers in modern radiation oncology. While ultra-hypofractionation has entered everyday clinical practice in different fields of the oncological care, curative treatments in one session are increasingly attractive for the potential favorable combination of logistic advantages with safety and clinical outcomes. This collaborative systematic review promoted by the ESTRO SBRT Focus Group in participation with members of different disease-site Focus Groups collects the available data in support of SF-SBRT for the curative treatment of the main extracranial primary tumors. The findings highlight that, for specific anatomical sites, SF-SBRT is both safe and effective though the results emphasize the critical importance of careful patient selection and mandatory technological requirements for treatment planning and delivery. This collaborative work provides a comprehensive overview of current evidence and identifies key knowledge gaps for future investigation and upcoming clinical trials.
SN  - 2405-6308
ER  -