Development of a rapid ATR-FTIR method for quantitative determination of glycerol carbonate in catalytic reaction mixtures
Abstract
Accurate quantification of glycerol carbonate (GLC) is essential for evaluating catalysts for glycerol transesterification with dimethyl carbonate. This study developed a rapid attenuated total reflectance Fourier transform infrared (ATR-FTIR) method for GLC determination in catalytic reaction mixtures and compared its performance with highperformance liquid chromatography with refractive index detection (HPLC-RID).
Quantification employed the integrated absorbance area at 1160-1210 cm⁻¹ relative to the N,N-dimethylformamide absorbance at 1670 cm⁻¹. Matrix-matched calibration was linear over 0-79,820 mg/L (R² = 0.9982). Methanol addition changed the calibration slope by approximately 0.70%. Passing-Bablok regression of 17 independently prepared synthetic samples gave a slope of 0.940 (95% confidence interval: 0.872-1.008) and an intercept of 1,565 mg/L (-412 to 4,128 mg/L). Bland-Altman analysis showed a mean difference of -985 mg/L and 95% limits of agreement from -7,799 to +5,829 mg/L, indicating appreciable differences between individual measurements. Application to FAU-type zeolite-catalyzed reactions generally reproduced HPLC-RID catalytic activity trends, although individual GLC yields differed. The proposed method enables rapid analysis within the investigated reaction system, but further evaluation of matrix effects and measurement uncertainty is required before broader application.
Related
- Editorial Note: Development and validation of a quantitative Proximity Extension Assay instrument with 21 proteins associated with cardiovascular risk (CVD-21)
- Lipase-catalyzed esterification of glycerol-derived acids: Toward sustainable production of value-added esters
- A New Family of Electron-Bifurcating Enzymes Represented by Ferredoxin- and NAD-Dependent Glycerol-3-Phosphate Oxidoreductase.
- Rational Design of Molecularly Imprinted Nanozymes for Selective Degradation of Poly(bisphenol A carbonate) (BPA-PC)
- Evolutionary plasticity of regulatory--catalytic coupling in mono- and poly-ADP-ribosyl transferases
BibTeX
@article{seejandee2026development,
title = {{Development of a rapid ATR-FTIR method for quantitative determination of glycerol carbonate in catalytic reaction mixtures}},
author = {Piyanat Seejandee and Sawitree Chaiburee and Thida Ounjaidee and Saruta Mueangkhun and Abdallah Amedlous and Svetlana Mintova and Nurak Grisdanurak and Sanchai Prayoonpokarach and Jatuporn Wittayakun},
journal = {Applied Surface Science},
year = {2026},
month = oct,
doi = {10.1016/j.apsusc.2026.168716},
url = {https://hal.science/hal-05854677v1},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Development of a rapid ATR-FTIR method for quantitative determination of glycerol carbonate in catalytic reaction mixtures
AU - Piyanat Seejandee
AU - Sawitree Chaiburee
AU - Thida Ounjaidee
AU - Saruta Mueangkhun
AU - Abdallah Amedlous
AU - Svetlana Mintova
AU - Nurak Grisdanurak
AU - Sanchai Prayoonpokarach
AU - Jatuporn Wittayakun
PY - 2026
DA - 2026/10/19
JO - Applied Surface Science
DO - 10.1016/j.apsusc.2026.168716
UR - https://hal.science/hal-05854677v1
AB - Accurate quantification of glycerol carbonate (GLC) is essential for evaluating catalysts for glycerol transesterification with dimethyl carbonate. This study developed a rapid attenuated total reflectance Fourier transform infrared (ATR-FTIR) method for GLC determination in catalytic reaction mixtures and compared its performance with highperformance liquid chromatography with refractive index detection (HPLC-RID). Quantification employed the integrated absorbance area at 1160-1210 cm⁻¹ relative to the N,N-dimethylformamide absorbance at 1670 cm⁻¹. Matrix-matched calibration was linear over 0-79,820 mg/L (R² = 0.9982). Methanol addition changed the calibration slope by approximately 0.70%. Passing-Bablok regression of 17 independently prepared synthetic samples gave a slope of 0.940 (95% confidence interval: 0.872-1.008) and an intercept of 1,565 mg/L (-412 to 4,128 mg/L). Bland-Altman analysis showed a mean difference of -985 mg/L and 95% limits of agreement from -7,799 to +5,829 mg/L, indicating appreciable differences between individual measurements. Application to FAU-type zeolite-catalyzed reactions generally reproduced HPLC-RID catalytic activity trends, although individual GLC yields differed. The proposed method enables rapid analysis within the investigated reaction system, but further evaluation of matrix effects and measurement uncertainty is required before broader application.
SN - 0169-4332
SN - 1873-5584
ER -