Acute resistance training significantly reduces malondialdehyde levels in women with a sedentary lifestyle: a randomized controlled trial
5 affiliations
- 1STKIP PGRI Trenggalek, Jl. Supriyadi str., 22, Trenggalek, Jawa Timur, 66319
- 2Universitas Negeri Surabaya, Surabaya, Jawa Timur, 60213
- 3Universitas Airlangga, Jl. Prof. Dr. Moestopo, 47, Pacar Kembang, Surabaya, Jawa Timur, 60132
- 4Universitas Sebelas Maret, Ir. Sutami str., 36, Surakarta, Jawa Tengah, 57126
- 5Haliç University, 5 Levent Mh., Temmuz Şehitler Caddesi, 15, No. 14/12, Eyüpsultan/İSTANBUL, 34060
Abstract
Increased oxidative stress is linked to a sedentary lifestyle and plays a role in the emergence of a number of chronic illnesses. One important biomarker for evaluating oxidative damage and lipid peroxidation in the body is malondialdehyde (MDA). One possible non-pharmacological strategy to lower oxidative stress levels is resistance exercise. This study sought to ascertain how resistance training affected MDA levels, a biomarker of oxidative stress. Experimental and control groups before and after were used in this experimental study. Individuals were selected through random sampling, and after their selection, two groups were formed: the treatment group received a resistance training intervention, and there was no activity in the control group, only sitting. The study involved twenty-two healthy women with a sedentary lifestyle. Study participants were between 18 and 26 years of age. Data collection took place over two days, beginning with gathering information about the subjects' characteristics. Before the physical exercises were performed, blood samples were collected to determine baseline (pre-test) values. After then, the participants warmed up. Then, the subjects performed resistance training according to their group. The exercises performed included resistance training to exhaustion at maximum intensity. After the resistance training, blood samples were taken as post-test data. According to the study results, the MDA level in the experimental group was 1.81±0.58 before the intervention and 1.15±0.43 after the intervention, this testifies that acute resistance training significantly reduces MDA levels in women who live a sedentary lifestyle (p<0.05). In the control group, the MDA level was 1.81±0.71 before and 1.89±1.23 after the intervention, indicating no statistically significant difference (p>0.05). Conclusions: Thus, it may be said that acute resistance training can reduce MDA levels, a biomarker of oxidative stress. Resistance training can be recommended as an alternative exercise for people with a sedentary lifestyle to improve their health, particularly by reducing oxidative stress, which has adverse health effects.
Related
- The effects of resistance exercise snacks via a mobile health app on musculoskeletal strength in sedentary young women: a randomized controlled trial
- Comparative effects of supervised aerobic and combined training with dietary counseling on metabolic biomarkers in sedentary adult male bank employees: a randomized controlled trial
- Reducing sedentary behavior and promoting physical activity in medical students: protocol of the PROMESS-Physical Activity randomized controlled clinical trial
- Study of Menopause and Resistance Training for Brain Health (SMART brain): a randomized controlled trial
- Comparison between practical and traditional blood flow restriction methods in upper limb resistance training: a study protocol for a randomized controlled clinical trial
BibTeX
@article{wibawa2026acute,
title = {{Acute resistance training significantly reduces malondialdehyde levels in women with a sedentary lifestyle: a randomized controlled trial}},
author = {J.C. Wibawa and N. Ayubi and L. Herawati and B.N. Putro and V.M. Sceisarriya and H.G. Pratama and N. Febrianto and M.S. Fudin and M. Kurnaz},
journal = {Medičnì Perspektivi},
year = {2026},
month = sep,
doi = {10.26641/2307-0404.2026.3.375417},
url = {https://doi.org/10.26641/2307-0404.2026.3.375417},
note = {CC BY},
}
RIS
TY - JOUR
TI - Acute resistance training significantly reduces malondialdehyde levels in women with a sedentary lifestyle: a randomized controlled trial
AU - J.C. Wibawa
AU - N. Ayubi
AU - L. Herawati
AU - B.N. Putro
AU - V.M. Sceisarriya
AU - H.G. Pratama
AU - N. Febrianto
AU - M.S. Fudin
AU - M. Kurnaz
PY - 2026
DA - 2026/09/01
JO - Medičnì Perspektivi
DO - 10.26641/2307-0404.2026.3.375417
UR - https://doi.org/10.26641/2307-0404.2026.3.375417
AB - Increased oxidative stress is linked to a sedentary lifestyle and plays a role in the emergence of a number of chronic illnesses. One important biomarker for evaluating oxidative damage and lipid peroxidation in the body is malondialdehyde (MDA). One possible non-pharmacological strategy to lower oxidative stress levels is resistance exercise. This study sought to ascertain how resistance training affected MDA levels, a biomarker of oxidative stress. Experimental and control groups before and after were used in this experimental study. Individuals were selected through random sampling, and after their selection, two groups were formed: the treatment group received a resistance training intervention, and there was no activity in the control group, only sitting. The study involved twenty-two healthy women with a sedentary lifestyle. Study participants were between 18 and 26 years of age. Data collection took place over two days, beginning with gathering information about the subjects' characteristics. Before the physical exercises were performed, blood samples were collected to determine baseline (pre-test) values. After then, the participants warmed up. Then, the subjects performed resistance training according to their group. The exercises performed included resistance training to exhaustion at maximum intensity. After the resistance training, blood samples were taken as post-test data. According to the study results, the MDA level in the experimental group was 1.81±0.58 before the intervention and 1.15±0.43 after the intervention, this testifies that acute resistance training significantly reduces MDA levels in women who live a sedentary lifestyle (p<0.05). In the control group, the MDA level was 1.81±0.71 before and 1.89±1.23 after the intervention, indicating no statistically significant difference (p>0.05). Conclusions: Thus, it may be said that acute resistance training can reduce MDA levels, a biomarker of oxidative stress. Resistance training can be recommended as an alternative exercise for people with a sedentary lifestyle to improve their health, particularly by reducing oxidative stress, which has adverse health effects.
SN - 2307-0404
SN - 2786-4804
ER -