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Peer-reviewedCC BY 4.0Cells

Stem Cell-Based Therapies in Companion Animals: Molecular Mechanisms, Clinical Applications, and Translational Perspectives

  • Weina Liu1,2
  • Yu Wang1
  • Wei An1
  • Zhenlong Wang1,3
  • Bing Han1,3
  • Hui Tao1,3
  • Yongli Zhang1,3
  • Fengjiao Gong1
  • Xiumin Wang1,3
  • Jinquan Wang1,3
  1. 1Key Laboratory of Feed Biotechnology, Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China
  2. 2College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China
  3. 3National Nanfan Research Institute (Sanya), Chinese Academy of Agricultural Sciences, Sanya 572024, China
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Abstract

Stem cell-based therapies, as regenerative and immunomodulatory strategies, show substantial potential in companion animals through tissue repair, functional recovery, and immune modulation. Despite advances in human stem cell research, veterinary clinical translation remains constrained by small sample sizes, short follow-up periods, and non-standardized cell dosing regimens and delivery protocols. The expanding repertoire of stem cell-based modalities and technologies—including mesenchymal stem cells, induced pluripotent stem cells, extracellular vesicles, and tissue engineering—provides promising avenues for clinical application. This review summarizes recent progress in stem cell-based therapies across multiple disease systems in dogs and cats, with particular attention to the molecular mechanisms underlying regenerative and immunomodulatory effects, cross-species translational strategies, current challenges, and combinatorial therapeutic approaches in companion animals. By examining mechanistic findings alongside preclinical and early clinical evidence, this review highlights the limitations of current knowledge and identifies research priorities for evaluating the safety and efficacy of stem cell-based therapies in dogs and cats.

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Cite

BibTeXRIS
BibTeX
@article{liu2026stem,
  title = {{Stem Cell-Based Therapies in Companion Animals: Molecular Mechanisms, Clinical Applications, and Translational Perspectives}},
  author = {Weina Liu and Yu Wang and Wei An and Zhenlong Wang and Bing Han and Hui Tao and Yongli Zhang and Fengjiao Gong and Xiumin Wang and Jinquan Wang},
  journal = {Cells},
  year = {2026},
  month = oct,
  doi = {10.3390/cells15201884},
  url = {https://www.mdpi.com/2073-4409/15/20/1884},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Stem Cell-Based Therapies in Companion Animals: Molecular Mechanisms, Clinical Applications, and Translational Perspectives
AU  - Weina Liu
AU  - Yu Wang
AU  - Wei An
AU  - Zhenlong Wang
AU  - Bing Han
AU  - Hui Tao
AU  - Yongli Zhang
AU  - Fengjiao Gong
AU  - Xiumin Wang
AU  - Jinquan Wang
PY  - 2026
DA  - 2026/10/15
JO  - Cells
DO  - 10.3390/cells15201884
UR  - https://www.mdpi.com/2073-4409/15/20/1884
AB  - Stem cell-based therapies, as regenerative and immunomodulatory strategies, show substantial potential in companion animals through tissue repair, functional recovery, and immune modulation. Despite advances in human stem cell research, veterinary clinical translation remains constrained by small sample sizes, short follow-up periods, and non-standardized cell dosing regimens and delivery protocols. The expanding repertoire of stem cell-based modalities and technologies—including mesenchymal stem cells, induced pluripotent stem cells, extracellular vesicles, and tissue engineering—provides promising avenues for clinical application. This review summarizes recent progress in stem cell-based therapies across multiple disease systems in dogs and cats, with particular attention to the molecular mechanisms underlying regenerative and immunomodulatory effects, cross-species translational strategies, current challenges, and combinatorial therapeutic approaches in companion animals. By examining mechanistic findings alongside preclinical and early clinical evidence, this review highlights the limitations of current knowledge and identifies research priorities for evaluating the safety and efficacy of stem cell-based therapies in dogs and cats.
SN  - 2073-4409
ER  -