Extracellular PKM2 Repairs Colon Damages in Colitis Model by Regulating Macrophage Polarity
- 1Division of Hematology and Oncology, School of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35233, USA
- 2Department of Biology, Georgia State University, Atlanta, GA 30303, USA
Abstract
Inflammatory immunity exacerbates tissue damage in the tissue injury. Resolution of the inflammation trigger tissue repair and regeneration. We report here that the extracellular PKM2 (EcPKM2) modulates immunity at colon damage site by facilitating M2 macrophage polarization in response to Dextran Sodium Sulfate (DSS)-induced damage. The effects of EcPKM2 on macrophage polarity led to decreased inflammation and facilitated the repairment of colon damages due to a reduction in epithelial cell death in a DSS-induced Ulcerative colitis mouse model. Interestingly, EcPKM2 facilitates intestinal mucosal lining repair by promoting colon epithelial proliferation. EcPKM2 protects intestinal epithelial cells from death and promotes the epithelial cell proliferation by promoting M2 macrophages’ polarity. Our study suggests a potential new therapeutic strategy by targeting macrophage polarity for Ulcerative Colitis treatment.
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BibTeX
@article{li2026extracellular,
title = {{Extracellular PKM2 Repairs Colon Damages in Colitis Model by Regulating Macrophage Polarity}},
author = {Bin Li and Guangda Peng and Naseer A. Kutchy and Siva C. Chabattula and Jenny J. Yang and Zhi-Ren Liu},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = nov,
doi = {10.3390/ijms27219853},
url = {https://www.mdpi.com/1422-0067/27/21/9853},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Extracellular PKM2 Repairs Colon Damages in Colitis Model by Regulating Macrophage Polarity
AU - Bin Li
AU - Guangda Peng
AU - Naseer A. Kutchy
AU - Siva C. Chabattula
AU - Jenny J. Yang
AU - Zhi-Ren Liu
PY - 2026
DA - 2026/11/03
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27219853
UR - https://www.mdpi.com/1422-0067/27/21/9853
AB - Inflammatory immunity exacerbates tissue damage in the tissue injury. Resolution of the inflammation trigger tissue repair and regeneration. We report here that the extracellular PKM2 (EcPKM2) modulates immunity at colon damage site by facilitating M2 macrophage polarization in response to Dextran Sodium Sulfate (DSS)-induced damage. The effects of EcPKM2 on macrophage polarity led to decreased inflammation and facilitated the repairment of colon damages due to a reduction in epithelial cell death in a DSS-induced Ulcerative colitis mouse model. Interestingly, EcPKM2 facilitates intestinal mucosal lining repair by promoting colon epithelial proliferation. EcPKM2 protects intestinal epithelial cells from death and promotes the epithelial cell proliferation by promoting M2 macrophages’ polarity. Our study suggests a potential new therapeutic strategy by targeting macrophage polarity for Ulcerative Colitis treatment.
SN - 1422-0067
ER -