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Peer-reviewedCC BYMicroPublication biology

Role of vitellogenins on the mitochondrial unfolded protein response.

  • Nathanial A Jordan1
  • Suzanne Angeli1
  1. 1Molecular and Biomedical Sciences, University of Maine.
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Abstract

Sex-specific differences influence aging and disease onset. Using Caenorhabditis elegans , we previously found that hermaphroditic nematodes activate a robust mitochondrial unfolded protein response (UPR mt ) in the intestines, while female nematodes do not. We hypothesized that the accumulation of vitellogenins in females was suppressing the UPR mt . Loss of vitellogenins via RNAi enhanced the UPR mt in hermaphrodites but had no impact on the UPR mt of females unless a combination of vitellogenins was simultaneously knocked down. Furthermore, combinatorial loss of vitellogenins did not restore the female UPR mt to hermaphroditic levels. We conclude that additional factors besides vitellogenins are involved in suppressing the intestinal UPR mt in female nematodes.

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Cite

BibTeXRIS
BibTeX
@article{jordan2026role,
  title = {{Role of vitellogenins on the mitochondrial unfolded protein response.}},
  author = {Nathanial A Jordan and Suzanne Angeli},
  journal = {MicroPublication biology},
  year = {2026},
  month = sep,
  doi = {10.17912/micropub.biology.002360},
  url = {https://europepmc.org/article/MED/42871934},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Role of vitellogenins on the mitochondrial unfolded protein response.
AU  - Nathanial A Jordan
AU  - Suzanne Angeli
PY  - 2026
DA  - 2026/09/29
JO  - MicroPublication biology
DO  - 10.17912/micropub.biology.002360
UR  - https://europepmc.org/article/MED/42871934
AB  - Sex-specific differences influence aging and disease onset. Using Caenorhabditis elegans , we previously found that hermaphroditic nematodes activate a robust mitochondrial unfolded protein response (UPR mt ) in the intestines, while female nematodes do not. We hypothesized that the accumulation of vitellogenins in females was suppressing the UPR mt . Loss of vitellogenins via RNAi enhanced the UPR mt in hermaphrodites but had no impact on the UPR mt of females unless a combination of vitellogenins was simultaneously knocked down. Furthermore, combinatorial loss of vitellogenins did not restore the female UPR mt to hermaphroditic levels. We conclude that additional factors besides vitellogenins are involved in suppressing the intestinal UPR mt in female nematodes.
SN  - 2578-9430
ER  -