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Peer-reviewedCC BY-NCChemical and Pharmaceutical Bulletin

Serinaphthoic Acids, New Amino-Naphthoic Acid Derivatives Produced by Serinicoccus marinus KDM482

  • Mai Sakaguchi
  • Ryota Okamura
  • Katsuki Kikuchi
  • Reiko Seki
  • Kenichiro Nagai
  • Akiho Yagi
  • Ryuji Uchida
  • Masashi Ando
  • Teruyoshi Tanaka
  • Takashi Fukuda
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Abstract

We previously discovered new dimerization compounds of 3-amino-2-naphthoic acid (3-A-2-N) produced by the cultivation of Serinicoccus marinus KDM482 with 3-A-2-N. In the present study, we investigated metabolites with a 3-A-2-N moiety and obtained two new metabolites, designated as serinaphthoic acids A (1) and B (2). A structural analysis using one-dimensional (1D) and 2D-NMR, IR, UV, and MS data revealed that 1 and 2 were both hybrid compounds consisting of the reagent 3-A-2-N and the natural moieties 2-thioformylbenzoic acid and 1-butene. In biological assays, 1 weakly inhibited the growth of Malme-3M cells by inducing apoptosis and also exhibited antibacterial activities against Staphylococcus aureus and Enterococcus faecalis.

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Cite

BibTeXRIS
BibTeX
@article{sakaguchi2026serinaphthoic,
  title = {{Serinaphthoic Acids, New Amino-Naphthoic Acid Derivatives Produced by Serinicoccus marinus KDM482}},
  author = {Mai Sakaguchi and Ryota Okamura and Katsuki Kikuchi and Reiko Seki and Kenichiro Nagai and Akiho Yagi and Ryuji Uchida and Masashi Ando and Teruyoshi Tanaka and Takashi Fukuda},
  journal = {Chemical and Pharmaceutical Bulletin},
  year = {2026},
  month = oct,
  doi = {10.1248/cpb.c26-00191},
  url = {https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00191/_article},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Serinaphthoic Acids, New Amino-Naphthoic Acid Derivatives Produced by Serinicoccus marinus KDM482
AU  - Mai Sakaguchi
AU  - Ryota Okamura
AU  - Katsuki Kikuchi
AU  - Reiko Seki
AU  - Kenichiro Nagai
AU  - Akiho Yagi
AU  - Ryuji Uchida
AU  - Masashi Ando
AU  - Teruyoshi Tanaka
AU  - Takashi Fukuda
PY  - 2026
DA  - 2026/10/20
JO  - Chemical and Pharmaceutical Bulletin
DO  - 10.1248/cpb.c26-00191
UR  - https://www.jstage.jst.go.jp/article/cpb/74/10/74_c26-00191/_article
AB  - We previously discovered new dimerization compounds of 3-amino-2-naphthoic acid (3-A-2-N) produced by the cultivation of Serinicoccus marinus KDM482 with 3-A-2-N. In the present study, we investigated metabolites with a 3-A-2-N moiety and obtained two new metabolites, designated as serinaphthoic acids A (1) and B (2). A structural analysis using one-dimensional (1D) and 2D-NMR, IR, UV, and MS data revealed that 1 and 2 were both hybrid compounds consisting of the reagent 3-A-2-N and the natural moieties 2-thioformylbenzoic acid and 1-butene. In biological assays, 1 weakly inhibited the growth of Malme-3M cells by inducing apoptosis and also exhibited antibacterial activities against Staphylococcus aureus and Enterococcus faecalis.
SN  - 1347-5223
SN  - 0009-2363
ER  -