Dopaminergic neurons linking threat processing to cardiac modulation and locomotor responses
- 1Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
- 2International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan
Abstract
Heartbeat and behavior are tightly coordinated during defensive states, yet the neuronal mechanisms linking threat processing to cardiac modulation—and the potential contribution of cardiac dynamics to behavioral output—remain poorly understood. Here, using simultaneous recordings of heartbeat and behavior in tethered Drosophila, we show that mechanical threat triggers locomotion together with rapid cardiac deceleration. We identify two pairs of dopaminergic neurons, termed DA-WED neurons, that mediate this cardiac response. Silencing these neurons markedly attenuates threat-induced cardiac deceleration, whereas optogenetic activation induces cardiac deceleration in the absence of threat. Two-photon calcium imaging further shows that DA-WED neurons are activated by mechanical threat, and manipulating their activity bidirectionally modulates threat-induced locomotion. Linking cardiac dynamics to behavior, direct optogenetic manipulation of cardiomyocytes that quantitatively reproduces threat-evoked cardiac deceleration is accompanied by increased locomotion. Together, these results identify a dopaminergic descending pathway that links threat processing to cardiac modulation and suggest that cardiac dynamics may contribute to shaping defensive behavior.
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BibTeX
@article{tsuji2026dopaminergic,
title = {{Dopaminergic neurons linking threat processing to cardiac modulation and locomotor responses}},
author = {Masato Tsuji and Daisuke Jinkoma and Yuki Uemura and Ayako Ogasawara and Kazuo Emoto},
journal = {eLife},
year = {2026},
month = nov,
doi = {10.7554/elife.111256},
url = {https://elifesciences.org/articles/111256},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Dopaminergic neurons linking threat processing to cardiac modulation and locomotor responses
AU - Masato Tsuji
AU - Daisuke Jinkoma
AU - Yuki Uemura
AU - Ayako Ogasawara
AU - Kazuo Emoto
PY - 2026
DA - 2026/11/05
JO - eLife
DO - 10.7554/elife.111256
UR - https://elifesciences.org/articles/111256
AB - Heartbeat and behavior are tightly coordinated during defensive states, yet the neuronal mechanisms linking threat processing to cardiac modulation—and the potential contribution of cardiac dynamics to behavioral output—remain poorly understood. Here, using simultaneous recordings of heartbeat and behavior in tethered Drosophila, we show that mechanical threat triggers locomotion together with rapid cardiac deceleration. We identify two pairs of dopaminergic neurons, termed DA-WED neurons, that mediate this cardiac response. Silencing these neurons markedly attenuates threat-induced cardiac deceleration, whereas optogenetic activation induces cardiac deceleration in the absence of threat. Two-photon calcium imaging further shows that DA-WED neurons are activated by mechanical threat, and manipulating their activity bidirectionally modulates threat-induced locomotion. Linking cardiac dynamics to behavior, direct optogenetic manipulation of cardiomyocytes that quantitatively reproduces threat-evoked cardiac deceleration is accompanied by increased locomotion. Together, these results identify a dopaminergic descending pathway that links threat processing to cardiac modulation and suggest that cardiac dynamics may contribute to shaping defensive behavior.
SN - 2050-084X
ER -