Association between adipose (pro)renin receptor expression and growth hormone deficiency in patients with non-functioning hypothalamic-pituitary masses
- 1Division of Hormonal Medicine and Bioregulatory Science, Department of Medicine, Tokyo Women’s Medical University, 8-1 Kawada-Cho, Shinjuku-Ku, Tokyo, Japan
- 2Department of Medicine, Tokyo Women’s Medical University Adachi Medical Center, Tokyo, Japan
- 3Department of Neurosurgery, Tokyo Women’s Medical University, Tokyo, Japan
Abstract
Purpose: Fat accumulation leads to obesity, which increases the risk of cardiovascular diseases. Recent studies have shown that adipose (pro)renin receptor ([P]RR) may play a role in fat accumulation, and we previously reported increased adipose (P)RR expression in growth hormone (GH) deficiency in mice; however, the association between human adipose (P)RR expression and GH deficiency remains unclear.
Methods: In this prospective study, abdominal subcutaneous adipose tissue was collected during pituitary surgery in patients with non-functioning hypothalamic-pituitary masses, and the associations between adipose (P)RR mRNA expression, determined using reverse transcription-polymerase chain reaction, and GH deficiency and other clinical parameters were investigated.
Results: Fifteen patients (5 craniopharyngioma, 4 non-functioning pituitary neuroendocrine tumor, 4 Rathke’s cleft cyst, and 2 other diseases) (mean age, 53 ± 17 years; male sex, 3 [20%]; and mean body mass index [BMI], 24.8 ± 4.3 kg/m2; GH deficiency, 8 [53%]) were included. Adipose (P)RR mRNA expression was significantly higher in patients with GH deficiency (P = 0.009) compared to those without, but was not significantly associated with other pituitary functions. Adipose (P)RR mRNA expression was significantly correlated with BMI (r = 0.526, P = 0.044) and body fat mass (r = 0.728, P = 0.026, n = 9). GH deficiency was significantly associated with (P)RR mRNA after adjustment for obesity (β = 2.257, 95% CI: 0.367–4.417, P = 0.023).
Conclusion: Adipose (P)RR expression may be increased in GH deficiency, suggesting the possible role of adipose (P)RR in fat accumulation in GH deficiency.
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BibTeX
@article{takano2026association,
title = {{Association between adipose (pro)renin receptor expression and growth hormone deficiency in patients with non-functioning hypothalamic-pituitary masses}},
author = {Noriyoshi Takano and Yasufumi Seki and Yuko Inoue and Kiyotaka Hirata and Daisuke Watanabe and Satoshi Morimoto and Yuichi Oda and Kosaku Amano and Takakazu Kawamata and Atsuhiro Ichihara},
journal = {Journal of Endocrinological Investigation},
year = {2026},
month = jul,
doi = {10.1007/s40618-026-02983-4},
url = {https://doi.org/10.1007/s40618-026-02983-4},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Association between adipose (pro)renin receptor expression and growth hormone deficiency in patients with non-functioning hypothalamic-pituitary masses
AU - Noriyoshi Takano
AU - Yasufumi Seki
AU - Yuko Inoue
AU - Kiyotaka Hirata
AU - Daisuke Watanabe
AU - Satoshi Morimoto
AU - Yuichi Oda
AU - Kosaku Amano
AU - Takakazu Kawamata
AU - Atsuhiro Ichihara
PY - 2026
DA - 2026/07/16
JO - Journal of Endocrinological Investigation
DO - 10.1007/s40618-026-02983-4
UR - https://doi.org/10.1007/s40618-026-02983-4
AB - Purpose: Fat accumulation leads to obesity, which increases the risk of cardiovascular diseases. Recent studies have shown that adipose (pro)renin receptor ([P]RR) may play a role in fat accumulation, and we previously reported increased adipose (P)RR expression in growth hormone (GH) deficiency in mice; however, the association between human adipose (P)RR expression and GH deficiency remains unclear. Methods: In this prospective study, abdominal subcutaneous adipose tissue was collected during pituitary surgery in patients with non-functioning hypothalamic-pituitary masses, and the associations between adipose (P)RR mRNA expression, determined using reverse transcription-polymerase chain reaction, and GH deficiency and other clinical parameters were investigated. Results: Fifteen patients (5 craniopharyngioma, 4 non-functioning pituitary neuroendocrine tumor, 4 Rathke’s cleft cyst, and 2 other diseases) (mean age, 53 ± 17 years; male sex, 3 [20%]; and mean body mass index [BMI], 24.8 ± 4.3 kg/m2; GH deficiency, 8 [53%]) were included. Adipose (P)RR mRNA expression was significantly higher in patients with GH deficiency (P = 0.009) compared to those without, but was not significantly associated with other pituitary functions. Adipose (P)RR mRNA expression was significantly correlated with BMI (r = 0.526, P = 0.044) and body fat mass (r = 0.728, P = 0.026, n = 9). GH deficiency was significantly associated with (P)RR mRNA after adjustment for obesity (β = 2.257, 95% CI: 0.367–4.417, P = 0.023). Conclusion: Adipose (P)RR expression may be increased in GH deficiency, suggesting the possible role of adipose (P)RR in fat accumulation in GH deficiency.
SN - 0391-4097
SN - 1720-8386
ER -