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Peer-reviewedCC BYRSC advances

Supercritical CO₂ extraction of onion seed oil and its synergistic effect with gentamicin against bacterial strains.

  • Selma Mestour1
  • Abdeslam-Hassen Meniai1
  • Sarra Melloul1
  • Arif Mermer2,3,4
  • Saban Tekin2
4 affiliations
  1. 1Process Engineering Laboratory, University of Constantine 3 Algeria [email protected].
  2. 2Experimental Medicine Application and Research Center, University of Health Sciences Istanbul Türkiye [email protected].
  3. 3Faculty of Pharmacy, University of Health Sciences Istanbul Türkiye.
  4. 4University of Health Sciences, Department of Biotechnology Istanbul Türkiye.
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Abstract

Antibiotic resistance represents a major global health challenge, requiring innovative strategies to enhance the effectiveness of existing antimicrobial agents. In this study, onion seed oil was extracted using supercritical CO₂ and evaluated for its potential to improve the antibacterial activity of the antibiotic gentamicin. The oil was characterized through physicochemical analyses, including FTIR spectroscopy, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Antibacterial activity was tested against Staphylococcus aureus and Escherichia coli using the disk diffusion method. The results demonstrated that onion seed oil exhibited significant antibacterial activity and enhanced the efficacy of gentamicin when used in combination. The synergistic interaction increased inhibition zone diameters by up to 20.4% for S. aureus and 22.95% for E. coli, even at low extract concentrations. These findings suggest that supercritical CO₂-extracted onion seed oil may serve as a promising natural adjuvant to improve antibiotic performance and combat bacterial resistance.

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Cite

BibTeXRIS
BibTeX
@article{mestour2026supercritical,
  title = {{Supercritical CO₂ extraction of onion seed oil and its synergistic effect with gentamicin against bacterial strains.}},
  author = {Selma Mestour and Abdeslam-Hassen Meniai and Sarra Melloul and Arif Mermer and Saban Tekin},
  journal = {RSC advances},
  year = {2026},
  month = oct,
  doi = {10.1039/d6ra04660f},
  url = {https://europepmc.org/article/MED/42903736},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Supercritical CO₂ extraction of onion seed oil and its synergistic effect with gentamicin against bacterial strains.
AU  - Selma Mestour
AU  - Abdeslam-Hassen Meniai
AU  - Sarra Melloul
AU  - Arif Mermer
AU  - Saban Tekin
PY  - 2026
DA  - 2026/10/20
JO  - RSC advances
DO  - 10.1039/d6ra04660f
UR  - https://europepmc.org/article/MED/42903736
AB  - Antibiotic resistance represents a major global health challenge, requiring innovative strategies to enhance the effectiveness of existing antimicrobial agents. In this study, onion seed oil was extracted using supercritical CO₂ and evaluated for its potential to improve the antibacterial activity of the antibiotic gentamicin. The oil was characterized through physicochemical analyses, including FTIR spectroscopy, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Antibacterial activity was tested against Staphylococcus aureus and Escherichia coli using the disk diffusion method. The results demonstrated that onion seed oil exhibited significant antibacterial activity and enhanced the efficacy of gentamicin when used in combination. The synergistic interaction increased inhibition zone diameters by up to 20.4% for S. aureus and 22.95% for E. coli, even at low extract concentrations. These findings suggest that supercritical CO₂-extracted onion seed oil may serve as a promising natural adjuvant to improve antibiotic performance and combat bacterial resistance.
SN  - 2046-2069
ER  -