Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 11 min ago
Peer-reviewedCC BYMolecular nutrition & food research

Whole-Food Protein Sources Differentially Modulate Postprandial Plasma Dileucine Profiles in the Post-Exercise State.

  • Žan Zupančič1
  • Geoffrey M Provenzano1,2
  • Calvin Chen1
  • Gena L Irwin1
  • Alexander V Ulanov3
  • Nicholas A Burd1,4
4 affiliations
  1. 1Department of Health and Kinesiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
  2. 2Institute of Neuroscience, Université Catholique De Louvain, Louvain-La-Neuve, Belgium.
  3. 3Roy J. Carver Biotechnology Center, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
  4. 4Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Read full textPDFDOICite

Abstract

Dileucine, a leucine-containing dipeptide, may enhance anabolic signaling more than leucine alone. This study examined postprandial plasma dileucine and leucine concentrations after ingesting animal- and plant- whole foods and their association with muscle protein synthesis rates (MPS). Secondary analysis was performed on plasma samples collected from two randomized controlled trials totaling 26 healthy adults (25 ± 4.3 y). Participants consumed low-fat pork (LFP), high-fat ground pork (HFP), complementary rice and beans (COMP), an iso-nitrogenous mixed nutrient beverage (ISO), or a carbohydrate control (CHO). Plasma concentrations and MPS was measured. Plasma dileucine increased significantly only after LFP ingestion (p < 0.05), with a greater 300-min iAUC compared to CHO (p = 0.038). Plasma leucine increased in all conditions except COMP and CHO with LFP demonstrating the highest concentrations (p < 0.05). A modest correlation was observed between dileucine Cmax and the change in MPS (ΔMPS; r = 0.436, p = 0.037), whereas leucine Cmax showed no significant association (r = 0.265, p = 0.102). Whole-food protein sources generally do not elevate plasma dileucine, except for LFP. While dileucine Cmax correlated with ΔMPS, the strength of this relationship suggests dileucine is likely one of several postprandial factors influencing MPS beyond free leucine.

Related

  1. Prebiotic, probiotic, and chlorophyllin interventions differentially attenuate melphalan-induced intestinal injury and modulate gut metabolite profiles
    Archana Kumari Redhu, Saithang Puia, Nitesh Chavan +7
    Frontiers in MicrobiologyPeer-reviewedCC BY 4.0MicrobiologyCrossref
  2. Cancer-associated fibroblast subtypes differentially modulate natural killer cells in cancer
    Leonor Nunes Rodrigues, Hafsa Munir, Ibone Thate Arrazola +6
    Cell ReportsPeer-reviewedCC BY5 citedImmunologyOpenAlex
  3. Peptidomimetics Inspired by α-Synuclein or Its Chaperone αB-Crystallin Differentially Modulate α-Synuclein Aggregation
    Nicolo Bisi, Josine Kothuis, Julia Kaffy +14
    Journal of Medicinal ChemistryPeer-reviewedCC BY 4.0Full text1 citedBiophysicsStructural biologyHAL
  4. Dopamine synthesis capacity and tau pathology differentially modulate rest-to-task functional network dynamics
    T. M. Morin, H.-Y. Chen, S. Aghasoltan +3
    bioRxivPreprintCC BYFull textNeurosciencebioRxiv
  5. Polarized macrophage-derived microvesicles differentially modulate intestinal barrier dysfunction and endoplasmic reticulum stress in ulcerative colitis.
    Chaoyue Liang, Qasim Khan, Yanling Wei +5
    Biology directPeer-reviewedCC BY-NC-NDFull text1 citedGenetics & genomicsEurope PMCPMC

Cite

BibTeXRIS
BibTeX
@article{zupancic2026wholefood,
  title = {{Whole-Food Protein Sources Differentially Modulate Postprandial Plasma Dileucine Profiles in the Post-Exercise State.}},
  author = {Žan Zupančič and Geoffrey M Provenzano and Calvin Chen and Gena L Irwin and Alexander V Ulanov and Nicholas A Burd},
  journal = {Molecular nutrition \& food research},
  year = {2026},
  month = oct,
  doi = {10.1002/mnfr.70628},
  url = {https://europepmc.org/article/MED/42894484},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Whole-Food Protein Sources Differentially Modulate Postprandial Plasma Dileucine Profiles in the Post-Exercise State.
AU  - Žan Zupančič
AU  - Geoffrey M Provenzano
AU  - Calvin Chen
AU  - Gena L Irwin
AU  - Alexander V Ulanov
AU  - Nicholas A Burd
PY  - 2026
DA  - 2026/10/01
JO  - Molecular nutrition & food research
DO  - 10.1002/mnfr.70628
UR  - https://europepmc.org/article/MED/42894484
AB  - Dileucine, a leucine-containing dipeptide, may enhance anabolic signaling more than leucine alone. This study examined postprandial plasma dileucine and leucine concentrations after ingesting animal- and plant- whole foods and their association with muscle protein synthesis rates (MPS). Secondary analysis was performed on plasma samples collected from two randomized controlled trials totaling 26 healthy adults (25 ± 4.3 y). Participants consumed low-fat pork (LFP), high-fat ground pork (HFP), complementary rice and beans (COMP), an iso-nitrogenous mixed nutrient beverage (ISO), or a carbohydrate control (CHO). Plasma concentrations and MPS was measured. Plasma dileucine increased significantly only after LFP ingestion (p < 0.05), with a greater 300-min iAUC compared to CHO (p = 0.038). Plasma leucine increased in all conditions except COMP and CHO with LFP demonstrating the highest concentrations (p < 0.05). A modest correlation was observed between dileucine Cmax and the change in MPS (ΔMPS; r = 0.436, p = 0.037), whereas leucine Cmax showed no significant association (r = 0.265, p = 0.102). Whole-food protein sources generally do not elevate plasma dileucine, except for LFP. While dileucine Cmax correlated with ΔMPS, the strength of this relationship suggests dileucine is likely one of several postprandial factors influencing MPS beyond free leucine.
SN  - 1613-4125
SN  - 1613-4133
ER  -