Skip to content
DraconiticResearch
Search Sources API
194,230 studies31 sourcesUpdated 18 min ago
Peer-reviewedCC BY-NC 4.0Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Spatial patterns of amyloid clearance after donanemab: A preliminary 12‐month real‐world amyloid PET study in Japanese patients with early Alzheimer's disease

  • Yuki Kujuro1
  • Marina Saito1
  • Manami Maruko1
  • Emi Qian2
  • Hidefumi Koh3
  • Hitoshi Katai4
  • Hidenori Hattori1
4 affiliations
  1. 1Department of Neurology Tachikawa Hospital Tokyo Japan
  2. 2Department of Neurology Keio University School of Medicine Tokyo Japan
  3. 3Department of Pulmonary Medicine Tachikawa Hospital Tokyo Japan
  4. 4Department of Gastroenterological Surgery Tachikawa Hospital Tokyo Japan
Read full textPDFDOICite

Abstract

Introduction: The regional pattern of amyloid clearance during donanemab treatment in routine practice is poorly characterized.

Methods: We analyzed amyloid positron emission tomography (Centiloid, regional standardized uptake value ratio, visual reads) at baseline and 12 months in 18 donanemab‐treated patients with early Alzheimer's disease.

Results: Clearance was near‐complete (removal 96%; 72% visually negative, i.e., full treatment‐related amyloid clearance), although lower in the 2 early‐onset (78%) than the 16 late‐onset patients (98%). Higher baseline burden and older age predicted greater clearance (r = 0.88, P < .001; r = 0.60, P = .009, respectively). This held regionally (r = 0.82–0.91, all P < .001), with the posterior cingulate and precuneus clearing first. Clearance was independent of medial temporal atrophy and unrelated to 12‐month cognitive change.

Discussion: Donanemab cleared regional amyloid in proportion to its baseline distribution, with deposition‐heavy regions clearing first and the temporal cortex retaining residual signal, independent of neurodegenerative stage and unrelated to short‐term cognition.

Related

  1. Preliminary Investigation of Injury Patterns and Preventive Behaviors Among Japanese Skateboarders: A Retrospective Cross-Sectional Study
    Naoyuki Hayakawa, Koki Hashimoto, Rie Nakazawa +1
    CureusPeer-reviewedCC BYFull textSurgery & anaesthesiaEurope PMCPMC
  2. Regional amyloid-PET clearance dynamics and anti-Aβ monoclonal antibody therapy: a preliminary real-world study.
    Alma Ghirelli, Giordano Cecchetti, Edoardo G Spinelli +15
    Alzheimer's & dementia (Amsterdam, Netherlands)Peer-reviewedCC BY-NCFull textPhysiologyEurope PMC
  3. Development of the Japanese Version of the Alzheimer's Disease Cooperative Study—Activities of Daily Living in Mild Cognitive Impairment Scale
    Daiki Ishimaru, Maki Suzuki, Hideki Kanemoto +9
    Psychogeriatrics : the official journal of the Japanese Psychogeriatric SocietyPeer-reviewedCC BYFull textGeneral medicineEurope PMC
  4. Astrocytic timekeepers and their influence on brain waste clearance in Alzheimer's disease.
    Chun Lei Koenders, Roland Chiu, Tiago Medeiros-Furquim +1
    Neurobiology of sleep and circadian rhythmsPeer-reviewedCC BYFull textPhysiologyEurope PMC
  5. Feasibility, Safety, and Preliminary Efficacy of Partnered Rhythmic Rehabilitation in Prodromal Alzheimer's Disease: A 12-Month Pilot Randomized Controlled Trial
    F. Rafiei Rezvani, D. Azimi, A. H. Nekouei +7
    medRxivPreprintAll rights reservedFull textPsychiatry & mental healthmedRxiv

Cite

BibTeXRIS
BibTeX
@article{kujuro2026spatial,
  title = {{Spatial patterns of amyloid clearance after donanemab: A preliminary 12‐month real‐world amyloid PET study in Japanese patients with early Alzheimer's disease}},
  author = {Yuki Kujuro and Marina Saito and Manami Maruko and Emi Qian and Hidefumi Koh and Hitoshi Katai and Hidenori Hattori},
  journal = {Alzheimer's \& Dementia : Diagnosis, Assessment \& Disease Monitoring},
  year = {2026},
  month = oct,
  doi = {10.1002/dad2.70539},
  url = {https://doi.org/10.1002/dad2.70539},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Spatial patterns of amyloid clearance after donanemab: A preliminary 12‐month real‐world amyloid PET study in Japanese patients with early Alzheimer's disease
AU  - Yuki Kujuro
AU  - Marina Saito
AU  - Manami Maruko
AU  - Emi Qian
AU  - Hidefumi Koh
AU  - Hitoshi Katai
AU  - Hidenori Hattori
PY  - 2026
DA  - 2026/10/30
JO  - Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
DO  - 10.1002/dad2.70539
UR  - https://doi.org/10.1002/dad2.70539
AB  - Introduction: The regional pattern of amyloid clearance during donanemab treatment in routine practice is poorly characterized.  Methods: We analyzed amyloid positron emission tomography (Centiloid, regional standardized uptake value ratio, visual reads) at baseline and 12 months in 18 donanemab‐treated patients with early Alzheimer's disease.  Results: Clearance was near‐complete (removal 96%; 72% visually negative, i.e., full treatment‐related amyloid clearance), although lower in the 2 early‐onset (78%) than the 16 late‐onset patients (98%). Higher baseline burden and older age predicted greater clearance (r = 0.88, P < .001; r = 0.60, P = .009, respectively). This held regionally (r = 0.82–0.91, all P < .001), with the posterior cingulate and precuneus clearing first. Clearance was independent of medial temporal atrophy and unrelated to 12‐month cognitive change.  Discussion: Donanemab cleared regional amyloid in proportion to its baseline distribution, with deposition‐heavy regions clearing first and the temporal cortex retaining residual signal, independent of neurodegenerative stage and unrelated to short‐term cognition.
SN  - 2352-8729
ER  -