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Peer-reviewedCC BYChemical research in toxicology

Characterization of 4-Bromo-2,5-dimethoxyphenethyl Tosylate, a Synthetic Intermediate of 2C-B, Identified in a Seized Pink Heart-Shaped Tablet.

  • Sara Casati1,2
  • Roberta F Bergamaschi1
  • Michele Dei Cas3
  • Alessandro Ravelli1
  • Lea Sicuro4
  • Gabriella Roda5
  • Chiara Ciccarelli6
  • Luca Mollica4
  • Claudio Guidotti6
  • Alessio Battistini1
  • Paola Rota1,7
7 affiliations
  1. 1Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, 20133Milan, Italy.
  2. 2Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122Milan, Italy.
  3. 3Dipartimento di Scienze della Salute, Università degli Studi di Milano, 20142Milan, Italy.
  4. 4Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, 20054Segrate, Italy.
  5. 5Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, 20133Milan, Italy.
  6. 6Gabinetto Regionale di Polizia Scientifica per la Lombardia, Polizia di Stato, Via Fatebenefratelli 11, 20121Milan, Italy.
  7. 7Institute for Molecular and Translational Cardiology (IMTC), San Donato Milanese, 20097Milan, Italy.
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Abstract

A pink heart-shaped tablet, seized by law enforcement authorities, was found to contain a compound structurally related to 4-bromo-2,5-dimethoxyphenethylamine (2C-B), a new psychoactive substance (NPS). An extensive analytical investigation based on one- and two-dimensional nuclear magnetic resonance (NMR) experiments, combined with liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and gas chromatography coupled to mass spectrometry (GC-MS) analyses, enabled the unambiguous identification of a new compound as 4-bromo-2,5-dimethoxyphenethyl tosylate, a putative synthetic intermediate in the synthesis of 2C-B. Finally, the targeted synthesis of the proposed structure provided independent confirmation of the correct structural assignment.

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Cite

BibTeXRIS
BibTeX
@article{casati2026characterization,
  title = {{Characterization of 4-Bromo-2,5-dimethoxyphenethyl Tosylate, a Synthetic Intermediate of 2C-B, Identified in a Seized Pink Heart-Shaped Tablet.}},
  author = {Sara Casati and Roberta F Bergamaschi and Michele Dei Cas and Alessandro Ravelli and Lea Sicuro and Gabriella Roda and Chiara Ciccarelli and Luca Mollica and Claudio Guidotti and Alessio Battistini and Paola Rota},
  journal = {Chemical research in toxicology},
  year = {2026},
  month = sep,
  doi = {10.1021/acs.chemrestox.6c00170},
  url = {https://europepmc.org/article/MED/42915732},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Characterization of 4-Bromo-2,5-dimethoxyphenethyl Tosylate, a Synthetic Intermediate of 2C-B, Identified in a Seized Pink Heart-Shaped Tablet.
AU  - Sara Casati
AU  - Roberta F Bergamaschi
AU  - Michele Dei Cas
AU  - Alessandro Ravelli
AU  - Lea Sicuro
AU  - Gabriella Roda
AU  - Chiara Ciccarelli
AU  - Luca Mollica
AU  - Claudio Guidotti
AU  - Alessio Battistini
AU  - Paola Rota
PY  - 2026
DA  - 2026/09/01
JO  - Chemical research in toxicology
DO  - 10.1021/acs.chemrestox.6c00170
UR  - https://europepmc.org/article/MED/42915732
AB  - A pink heart-shaped tablet, seized by law enforcement authorities, was found to contain a compound structurally related to 4-bromo-2,5-dimethoxyphenethylamine (2C-B), a new psychoactive substance (NPS). An extensive analytical investigation based on one- and two-dimensional nuclear magnetic resonance (NMR) experiments, combined with liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and gas chromatography coupled to mass spectrometry (GC-MS) analyses, enabled the unambiguous identification of a new compound as 4-bromo-2,5-dimethoxyphenethyl tosylate, a putative synthetic intermediate in the synthesis of 2C-B. Finally, the targeted synthesis of the proposed structure provided independent confirmation of the correct structural assignment.
SN  - 0893-228X
SN  - 1520-5010
ER  -